1. Membrane Transporter/Ion Channel
  2. CRM1

CRM1

Chromosome maintenance protein 1 (CRM1) is a nuclear export receptor involved in the active transport of tumor suppressors (eg, p53 and nucleophosmin) whose function is altered in cancer because of increased expression and overactive transport. Blocking CRM1-mediated nuclear export of such proteins is a novel therapeutic strategy to restore tumor suppressor function. Orally bioavailable selective inhibitors of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this protein have been recently developed.

CRM1 is the sole exporter of many tumor-suppressor proteins (TSPs), and functions as a proto-oncogene by transporting these tumor suppressors from the nucleus, where they are active, to the cytoplasm, where their activity is abrogated.

CRM1 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-100423
    KPT-8602 Inhibitor 99.68%
    KPT-8602 是一个第二代的 exportin-1抑制剂。
  • HY-17536
    KPT-330 Inhibitor 98.45%
    KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor.
  • HY-15611
    KPT-185 98.24%
    KPT-185 is an orally bioavailable selective inhibitor of CRM1 amd displayes potent antiproliferative properties at submicromolar concentrations (IC50 values:100-500nM), induced apoptosis (average 5-fold increase), cell-cycle arrest, and myeloid differenti
  • HY-100423A
    KPT-8602 Z-isomer Inhibitor
    KPT-8602 Z-isomer是活性较弱的KPT-8602异构体。KPT-8602为高效的CRM1抑制剂。
  • HY-17539
    KPT-276
    KPT-276, analog of KPT-185, is an orally bioavailable selective inhibitors of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of CRM1.
  • HY-15970
    Verdinexor Inhibitor
    Verdinexor(KPT-335)是新型口服活性出核抑制剂(SINE),能有效抑制犬肿瘤细胞系出核蛋白Exportin 1(XPO1/CRM1),也能降低流感病毒的复制水平。