1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Kinesin

Kinesin

Kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule filaments, and are powered by the hydrolysis of ATP (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo. Most kinesins walk towards the plus end of a microtubule, entails transporting cargo from the centre of the cell towards the periphery. Kinesins were discovered as microtubule (MT)-based anterograde intracellular transport motors. The founding member of this superfamily, the genomes of mammals encode more than 40 kinesin proteins, organized into at least 14 families named kinesin-1 through kinesin-14.

Kinesin 相关产品 (18):

Cat. No. Product Name Effect Purity
  • HY-15187
    ARRY-520 Inhibitor 99.41%
    ARRY-520 是一种合成的纺锤体驱动蛋白 (KSP) 抑制剂,IC50 值为 6 nM。
  • HY-10299
    GSK-923295 Inhibitor 99.77%
    GSK-923295 是一种特异性的变构 CENP-E 驱动蛋白 ATPase 活性抑制剂,作用于人类和犬类此酶,Ki 分别为 3.2±0.2 nM 和 1.6±0.1 nM。
  • HY-15948
    Kif15-IN-1 Inhibitor 99.04%
    Kif15-IN-1是Kif15驱动蛋白抑制剂,抑制多种肿瘤细胞增殖。
  • HY-50759
    Ispinesib Inhibitor 98.40%
    Ispinesib (SB-715992)是高亲和性的KSP(HsEg5)特异性抑制剂,Ki为1.7 nM。
  • HY-15857
    CW-069 Inhibitor >98.0%
    CW-069是微管动力蛋白HSET变构抑制剂,比对KSP的抑制性高。
  • HY-101298
    Paprotrain Inhibitor
    Paprotrain是可渗透细胞的kinesin MKLP-2的抑制剂,同时对DYRK1A有中等的抑制作用,IC50值为5.5 μM。
  • HY-15949
    Kif15-IN-2 Inhibitor
    Kif15-IN-2是Kif15驱动蛋白抑制剂,抑制多种肿瘤细胞增殖。
  • HY-14846
    Litronesib Inhibitor 99.50%
    Litronesib是一种选择性的Eg5变构抑制剂, 这可能破坏有丝分裂, 细胞凋亡, 因此导致肿瘤细胞死亡。
  • HY-15187A
    ARRY-520 R enantiomer Inhibitor 99.34%
    ARRY-520 R对映体是ARRY-520的R型,是KSP抑制剂,IC50为6 nM。
  • HY-101071A
    Monastrol Inhibitor 99.89%
    Monastrol是具有高效性和细胞渗透性的有丝分裂驱动蛋白Eg5的抑制剂,IC50值为14 μM.
  • HY-12660
    MPI-0479605 Inhibitor
    MPI-0479605是有效的, ATP竞争性的Mps1选择性抑制剂, IC50 为1.8 nM, 比作用于其他激酶选择性高40多倍。
  • HY-12069
    SB-743921 Inhibitor 98.25%
    SB-743921是第二代高活性KSP抑制剂,Ki为0.1 nM,对MKLP1,Kin2,Kif1A,Kif15,KHC,Kif4和CENP-E无亲和力。
  • HY-100816
    Rbin-1 Inhibitor >98.0%
    Robin-1 是一种有效的,可逆的特异性真核核糖体生物合成抑制剂,GI50 为 136±7 nM。
  • HY-19530
    PF-2771 Inhibitor
    PF-2771是一种有效的选择性CENP-E抑制剂, PF-2771抑制 CENP-E 活性, IC50值为16.1 ± 1.2 nM。
  • HY-15000
    EMD534085 Inhibitor 98.61%
    EMD534085是有效选择性的有丝分裂驱动蛋白-5 (kinesin-5)的抑制剂,IC50值为8 nM。
  • HY-19944
    Dimethylenastron Inhibitor
    Dimethylenastron是一种Eg5抑制剂。
  • HY-19966
    K858 Inhibitor
    K858选择性抑制Eg5 ATPase 活性, IC50为1.3 μM。
  • HY-14846A
    Litronesib Racemate 99.00%
    Litronesib Racemate 是 litronesib 的外消旋体。Litronesib 是选择性的 Eg5 别构抑制剂。