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Kinesin

Kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule filaments, and are powered by the hydrolysis of ATP (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo. Most kinesins walk towards the plus end of a microtubule, entails transporting cargo from the centre of the cell towards the periphery. Kinesins were discovered as microtubule (MT)-based anterograde intracellular transport motors. The founding member of this superfamily, the genomes of mammals encode more than 40 kinesin proteins, organized into at least 14 families named kinesin-1 through kinesin-14.

Kinesin (10)
产品名称 目录号 简述
CW-069 HY-15857

CW-069是微管动力蛋白HSET变构抑制剂,比对KSP的抑制性高。

EMD534085 HY-15000

EMD534085是有效选择性的有丝分裂驱动蛋白-5 (kinesin-5)的抑制剂,IC50值为8 nM。

GSK-923295 HY-10299

GSK-923295 是一种特异性的变构 CENP-E 驱动蛋白 ATPase 活性抑制剂,作用于人类和犬类此酶,Ki 分别为 3.2±0.2 nM 和 1.6±0.1 nM。

Kif15-IN-1 HY-15948

Kif15-IN-1是Kif15驱动蛋白抑制剂,抑制多种肿瘤细胞增殖。

Kif15-IN-2 HY-15949

Kif15-IN-2是Kif15驱动蛋白抑制剂,抑制多种肿瘤细胞增殖。

Monastrol HY-101071A

Monastrol是具有高效性和细胞渗透性的有丝分裂驱动蛋白Eg5的抑制剂,IC50值为14 μM.

MPI-0479605 HY-12660

MPI-0479605 is a potent, ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, > 40-fold selectivity over other kinases.

Paprotrain HY-101298

Paprotrain是可渗透细胞的kinesin MKLP-2的抑制剂,同时对DYRK1A有中等的抑制作用,IC50值为5.5 μM。

PF-2771 HY-19530

PF-2771 is a potent, selective CENP-E inhibitor, PF-2771 inhibits CENP-E motor activity with an IC50 of 16.1 ± 1.2 nM.

Rbin-1 HY-100816

Robin-1 是一种有效的,可逆的特异性真核核糖体生物合成抑制剂,GI50 为 136±7 nM。

Tags: Kinesin 抑制 | Kinesin 蛋白 | Kinesin 抑制剂 | Kinesin FDA上市药物 | Kinesin 和癌症 | Kinesin 活性 | Kinesin 激活 | Kinesin 信号通路 | Kinesin 抑制剂筛选 | Kinesin 高通量筛选 | Kinesin 抑制剂临床 | Kinesin 抑制剂药物 | Kinesin 抑制剂综述 | Kinesin 抑制剂研发 | Kinesin 抑制剂供应商 | Kinesin 抑制剂分销商

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