1. Neuronal Signaling
  2. AChE

AChE

Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase.

AChE 相关产品 (34):

Cat. No. Product Name Effect Purity
  • HY-76299
    Galanthamine Inhibitor 99.78%
    Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂,IC50 为 500 nM。
  • HY-B0034
    Donepezil Hydrochloride Inhibitor 99.97%
    Donepezil(E 2020)盐酸盐是非竞争性的AChE抑制剂,能穿过血脑屏障,增加皮质中的乙酰胆碱水平。
  • HY-17368
    Rivastigmine Inhibitor 99.39%
    Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
  • HY-17552
    sn-Glycero-3-phosphocholine Activator >98.0%
    L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate)是存在于脑和奶中的天然胆碱化合物,也是拟副交感神经乙酰胆碱前体。
  • HY-B0942
    Benzethonium chloride Inhibitor >98.0%
    Benzethonium chloride作用于在爪蟾卵母细胞,抑制人重组α7和α4β2神经元烟碱性乙酰胆碱受体。
  • HY-110389
    Pitofenone hydrochloride Inhibitor 99.88%
    Pitofenone hydrochloride 是一种解痉化合物,能够抑制乙酰胆碱酯酶 (AChE) 的活性,对于来自牛红细胞和电鳗的乙酰胆碱酯酶的 Ki 值分别为 36 和 45 μM。
  • HY-17387
    (-)-Huperzine A Inhibitor >98.0%
    Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
  • HY-A0009
    Galanthamine hydrobromide Inhibitor 99.43%
    Galanthamine氢溴酸盐是长效的中心活性的乙酰胆碱酯酶(AChE)抑制剂,IC50为410 nM,同时是神经元烟碱乙酰胆碱受体的变构增强剂。
  • HY-17388
    (±)-Huperzine A Inhibitor >98.0%
    Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
  • HY-B0882
    Edrophonium chloride Inhibitor >98.0%
    Edrophonium chloride是乙酰胆碱酯酶可逆性抑制剂。
  • HY-N0342
    Scopoletin Inhibitor 99.57%
    Scopoletin 是一种乙酰胆碱酯酶 (AChE) 抑制剂。
  • HY-N0226A
    Epiberberine chloride Inhibitor 99.60%
    Epiberberine chloride 是一种天然生物碱类化合物,为 BACE1 抑制剂,对 CYP2D6,醛糖还原酶 (aldose reductase),α肾上腺素受体 (alpha-adrenoceptor),AChE 等也有抑制作用。
  • HY-B1200
    Pralidoxime chloride Activator >99.0%
    Pralidoxime chloride属于肟类化合物, 有效治疗有机磷中毒,对中毒乙酰胆碱酯酶具有恢复作用。
  • HY-B0732
    Itopride hydrochloride Inhibitor 99.95%
    Itopride盐酸盐是乙酰胆碱酯酶(AChE)抑制剂和D2DR抑制剂。
  • HY-N0285
    Imperatorin Inhibitor 98.11%
    Imperatorin 是一种有效的 NO synthesis 抑制剂,IC50 为 9.2 μmol,也是 BChE 抑制剂,IC50 为 31.4 μmol。Imperatorin 是 TRPV1 的微弱激动剂,EC50 为 12.6±3.2 μM。
  • HY-B0207A
    Pyridostigmine bromide Inhibitor >98.0%
    Pyridostigmine是可逆的胆碱酯酶抑制剂。
  • HY-I0020
    Galanthaminone Inhibitor 99.53%
    Galanthaminone是竞争性可逆的胆碱酯酶(AChE)抑制剂,可作用于多种记忆障碍疾病。
  • HY-B0949
    Protriptyline hydrochloride Inhibitor 99.91%
    Protriptyline是一种三环抗抑郁药(TCA),含有一个仲胺,治疗抑郁和ADHD。与其他抗抑郁药相比是独一无二的,Protriptyline是激励代替镇静,并且有时用于嗜睡症,实现促醒效果。
  • HY-N0923
    Corydaline Inhibitor 98.17%
    紫堇碱(Corydaline)是天然提取的乙酰胆碱酯酶抑制剂。
  • HY-14566
    Donepezil Inhibitor
    Donepezil(E 2020)是AChE抑制剂,对bAChE和hAChE的IC50分别为8.12 nM和11.6 nM。
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