1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. LXR

LXR

LXRs (Liver X Receptor α and β) are nuclear receptors that act as ligand-activated transcription factors. LXR activation causes upregulation of genes involved in reverse cholesterol transport (RCT), including ABCA1 and ABCG1 transporters, in macrophage and intestine.

LXRα/β are ligand-activated transcription factors of the nuclear hormone receptor superfamily that stimulate transcription of several genes, including ABCA1 and apoE. LXRα and LXRβ respond to the same oxysterol ligands and activate transcription as obligate heterodimeric complexes with retinoid X receptors.

Synthetic LXR agonists activate both LXRα and LXRβ, cross the blood-brain barrier, and efficiently induce expression of LXR target genes including ABCA1 and apoE.

LXR 相关产品 (17):

Cat. No. Product Name Effect Purity
  • HY-10626
    T0901317 Agonist 99.64%
    T0901317 是有效,选择性的 LXRFXR 激动剂,EC50 分别为50 nM 和 5 μM。
  • HY-10627A
    GW3965 hydrochloride Agonist 99.70%
    GW3965 hydrochloride是 LXR 的激动剂,抑制hLXRα 和 hLXRβ的EC50 分别为190 和 30 nM。
  • HY-N2371
    27-Hydroxycholesterol Agonist 99.38%
    27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。
  • HY-108688
    GSK2033 Antagonist 98.83%
    GSK2033 是一种 LXR 拮抗剂,对于 LXRαLXRβpIC50 值分别为 7 和 7.4。
  • HY-10629
    LXR-623 Agonist 99.40%
    LXR-623是可以渗透血脑屏障的 LXRα 部分激动剂和 LXRβ 完全激动剂,IC50 分别为24 nM 和 179 nM。
  • HY-111498A
    RGX-104 free Acid Agonist 99.97%
    RGX-104 free Acid 是具有口服生物活性的、有效的肝X核激素受体 (LXRβ) 激动剂,通过ApoE基因的转录激活调节先天免疫。
  • HY-101442
    SR9238 Antagonist 99.94%
    SR9238 是一种合成的 LXR 拮抗剂,对于 LXRαLXRβIC50 值分别为 214 nM 和 43 nM。
  • HY-16972
    SR9243 Antagonist 99.90%
    SR9243 是 liver-X-receptor (LXR) 的反向激动剂,能够诱导 LXR-辅阻遏物相互作用。
  • HY-N0835
    (20S)-Protopanaxatriol Inhibitor >98.0%
    (20S)-Protopanaxatriol 是人参皂苷的代谢物,通过 glucocorticoid receptoroestrogen receptor 起作用,同时为 LXRα 的抑制剂。
  • HY-18282
    AZ876 Agonist 99.89%
    AZ876是一个新颖的LXR兴奋剂, AZ876在人的(h)LXRα和hLXRβ比GW3965 (HY-10627)要分别强25和2.5倍。
  • HY-101973
    XL041 Agonist 99.11%
    XL041 (BMS-852927) 是一种 LXRβ 选择性激动剂。
  • HY-N2370
    24-Hydroxycholesterol Activator >98.0%
    24-Hydroxycholesterol 是一种天然的固醇类物质,是n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂。
  • HY-19919
    BMS-779788 Agonist >98.0%
    BMS-779788是LXR的部分激动剂,其对LXRα和LXRβIC50值分别为68和 14 μM。
  • HY-111498
    RGX-104 Agonist 99.81%
    RGX-104是一种小分子 LXR 激动剂,通过ApoE基因的转录激活调节先天免疫。
  • HY-10627
    GW3965 Agonist
    GW3965是LXR激动剂,对hLXRα和hLXRβ的EC50分别为190和30 nM。
  • HY-N3216
    Nagilactone B Agonist >98.0%
    Nagilactone B,是从 Podocarpus nagi 根皮中提取的,是一种肝 X 受体 (LXR) 激动剂。
  • HY-109073
    Rovazolac Modulator 99.82%
    Rovazolac是从来自专利WO2013130892A1中的肝脏x受体 (liver x receptor (LXR)) 调节剂。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.