1. Anti-infection
  2. HCV

HCV

Hepatitis C virus (HCV) is a positive-strand RNA virus grouped in the genus Hepacivirus within the family Flaviviridae. HCV is classified into at least 6 genotypes (gt), and its error-prone polymerase leads to more than 50 subtypes. The long open reading frame, which encodes the HCV polyprotein, is processed by host and viral proteases and gives rise to three structural proteins (the capsid protein core and envelope glycoproteins E1 and E2) and seven nonstructural (NS) proteins (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B). NS2 and p7 are essential for virus assembly but not RNA replication, whereas NS3 to NS5B are involved in a membrane-associated RNA replicase complex (RC). The NS3 protein is composed of a serine protease and an RNA helicase/nucleoside triphosphatase (NTPase), NS4A serves as a cofactor for NS3 serine protease, NS5B is the RNA-dependent RNA polymerase, and NS5A is considered to play key roles in multiple steps of the HCV life cycle.NS5A inhibitors exhibit a rapid inhibition of virus infectivity shortly after administration to HCV-infected cells.

The HCV protein NS5A prevents the apoptosis-enabling loss of intracellular potassium by inhibiting Kv2.1 function and thus blocking hepatocyte cell death.

The HCV RNA-dependent RNA polymerase (RdRp) has long been a prime target for antiviral development because of its critical role in viral replication and the absence of a mammalian homologous enzyme.

The combination of lucidone and alpha interferon, the protease inhibitor Telaprevir, the NS5A inhibitor BMS-790052, or the NS5B polymerase inhibitor PSI-7977, synergistically suppresses HCV RNA replication.

HCV 相关产品 (81):

Cat. No. Product Name Effect Purity
  • HY-14434
    Asunaprevir Inhibitor 99.27%
    Asunaprevir 是一种有效的 hepatitis C virus (HCV) NS3 protease 抑制剂,IC50 值为 0.2 nM-3.5 nM。
  • HY-15005
    PSI-7977 Inhibitor 99.95%
    PSI-7977是 HCV RNA复制抑制剂,EC50 为92 nM。
  • HY-10241
    Simeprevir Inhibitor 99.34%
    Simeprevir 是一种有效的 HCV NS3/4A蛋白酶抑制剂,抑制 HCV 复制的EC50 值为 8 nM。
  • HY-15602
    Ledipasvir Inhibitor >98.0%
    Ledipasvir 是一种有效的 HCV NS5A 抑制剂,能够抑制 GT1a 和 GT1b 复制子,EC50 值分别为 34 pM 和 4 pM。
  • HY-12594
    Paritaprevir Inhibitor 98.87%
    Paritaprevir是一种有效的非结构蛋白3/4A (NS3/4A) 蛋白酶抑制剂, 对HCV 1a和1b的EC50值分别为1 和0.21 nM。
  • HY-109035
    Inarigivir soproxil Inhibitor
    Inarigivir soproxil 是先天免疫的激动剂,显示了对丙型肝炎病毒 (HCV) 耐药突变型有良好的抗病毒活性,其对 HCV 1a/1b 两种突变型的 EC50 值分别为 2.2,1.0 μM。
  • HY-18564
    HCV-IN-3 Inhibitor
    HCV-IN-3 是 hepatitis C virus (HCV) NS3/4a 蛋白的一个抑制剂,其 IC50 值为 20 μM,Kd 值为 29 μM。
  • HY-10466
    Daclatasvir Inhibitor 99.31%
    Daclatasvir 是一种有效的 HCV NS5A 抑制剂,作用于基因型 1a 和 1b 复制子,平均 EC50 为 50 和 9 pM。
  • HY-B0434
    Ribavirin Inhibitor >98.0%
    Ribavirin是广谱的抗病毒药,可抑制HCVHIVlRSV等病毒。
  • HY-15789
    Elbasvir Inhibitor 99.97%
    Elbasvir (MK-8742) 是丙型肝炎病毒非结构蛋白5A (HCV NS5A) 抑制剂, 对基因型1a,1b和2a的 EC50 分别为4,3 和3 nM。
  • HY-B0094
    Artemisinin Inhibitor >98.0%
    Artemisinin是从青蒿 (Artemisia annua L.) 植物的地上部分分离的抗疟疾药物。
  • HY-P0025
    NIM811 Inhibitor 99.55%
    NIM811 (SDZ NIM811) 是一种有效的线粒体渗透转换 (mitochondrial permeability transition) 抑制剂。
  • HY-15298
    MK-5172 Inhibitor 99.21%
    MK-5172 是选择性的丙型肝炎病毒 NS3/4a蛋白酶抑制剂,作用于 gt1b,gt1a,gt2a,gt2b 和 gt3a的 Ki 分别为 0.01 nM,0.01 nM,0.08 nM,0.15 nM 和 0.90 nM。
  • HY-13997
    Ombitasvir Inhibitor 99.89%
    Ombitasvir 是一种 HCV NS5A 抑制剂,对 HCV 基因型 1-5 和 6a 的 EC50 值分别为 0.82-19.3 pM 和 366 pM。
  • HY-12530
    Velpatasvir Inhibitor 99.71%
    Velpatasvir (VEL, GS-5816是一个新颖的NS5A抑制剂。
  • HY-10235
    Telaprevir Inhibitor 99.89%
    Telaprevir 是一种有效的选择性的可逆 HCV NS3-4A protease 抑制剂,作用于基因 1型 (H株) NS3 蛋白酶结构域和 NS4A 辅因子肽,Ki 为 7 nM。
  • HY-10237
    Boceprevir Inhibitor
    Boceprevir 是一种口服有效的选择性的 HCV NS3 protease 抑制剂,酶实验中Ki 为 14 nM,在含细胞体系的复制实验中,EC90 为 350 nM。
  • HY-16134A
    Celgosivir hydrochloride Inhibitor >98.0%
    Celgosivir hydrochloride (MDL 28574A) 是α-葡萄糖苷酶I (α-glucosidase I)抑制剂,在体外实验中的IC50值为1.27 μM。
  • HY-10238
    Danoprevir Inhibitor
    Danoprevir 是一种模拟肽类抑制剂,能够抑制 HCV NS3/4A proteaseIC50 值为 0.2-3.5 nM。
  • HY-17634
    Glecaprevir Inhibitor 99.65%
    Glecaprevir 是一种新型的 HCV NS3/4A 蛋白酶 (HCV NS3/4A protease) 抑制剂,其 IC50 值在 3.5 和 11.3 nM 之间。
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