1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT

GlyT

Glycine transporters (GlyTs) belong to a large family of Na+/Cl--dependent transporter proteins that includes transporters for monoamines [5-hydroxytryptamine (serotonin), noradrenaline and dopamine] and γ-aminobutyric acid. GlyT-mediated glycine uptake is energetically coupled with the transmembrane sodium gradient maintained by the Na+/K+-ATPase.

GlyT1 is essential for regulating glycine concentrations at synaptic receptors.

GlyT2 is uniquely designed for neurotransmitter recycling at inhibitory glycinergic synapses, and loss of GlyT2 function generates a severely hyperexcited state.

GlyT 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-10809
    Bitopertin Inhibitor 99.75%
    Bitopertin 是一种有效的非竞争性glycine reuptake 抑制剂,抑制甘氨酸摄取,IC50 为 25 nM。
  • HY-100416A
    LY2365109 hydrochloride Inhibitor 98.83%
    LY2365109是一个强的和选择性的GlyT1抑制剂,IC50是15.8 nM.
  • HY-18723
    GlyT2-IN-1 Inhibitor 99.94%
    GlyT2-IN-1是甘氨酸转运体GLYT2抑制剂, 是一种新型的机械传导通道Piezo1激动剂, 作用于Piezo1-而非载体转染的细胞, 引发Ca2+外流。
  • HY-10809A
    Bitopertin R enantiomer Inhibitor
    RG1678 (Bitopertin)R型对映体是非竞争性甘氨酸重吸收(GlyT1)抑制剂。
  • HY-19887
    Tilapertin Inhibitor
    Tilapertin 是甘氨酸转运蛋白 1 型 (GlyT1) 的口服抑制剂。
  • HY-101037
    Sarcosine Inhibitor
    Sarcosine 1型甘氨酸转运蛋白 (GlyT) 抑制剂和甘氨酸结合位点的N-甲基-D-天冬氨酸 (NMDA) 受体共激动剂。
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