1. Apoptosis
  2. PKD

PKD

PKD (Protein kinase D) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G-protein-coupled receptor agonists and polypeptide growth factors. PKD family of serine/threonine protein kinases has three members: PKD1, PKD2, PKD3. PKD1, the most studied member of the family, is increasingly implicated in the regulation of a complex array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis, and cancer. PKD mediates such a diverse array of normal and abnormal biological functions via dynamic changes in its spatial and temporal localization, combined with its distinct substrate specificity.

PKD Isoform Specific Products:

  • PKD1

  • PKD2

  • PKD3

PKD 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-13942
    1-NM-PP1 Inhibitor 98.83%
    1-NM-PP1是可渗透细胞的蛋白激酶D (PKD) 抑制剂,IC50 为0.398 μM。
  • HY-12239
    CID755673 Inhibitor 98.98%
    CID755673是高效选择性的PKD1抑制剂,IC50 of 值为182 nM.
  • HY-15698A
    CRT0066101 dihydrochloride Inhibitor 98.94%
    CRT0066101 dihydrochloride是有效,选择性的 PKD 抑制剂,对PKD1,2和3的IC50值分别为1,2.5和2 nM。
  • HY-13454
    CID 2011756 Inhibitor
    CID 2011756 是一种广谱的,ATP 竞争性的 PKD 抑制剂,对 PKD1 的 IC50 值为 3.2 µM,在细胞中对 PKD2 和 PKD3 的 IC50 值分别为 0.6 和 0.7 µM;CID 2011756 同时具有抗肿瘤活性。
  • HY-15528
    kb NB 142-70 Inhibitor 98.24%
    kb NB 142-70 是一种有效的 PKD 抑制剂,对 PKD1,PKD2 和 PKD3 的 IC50 值分别为 28.3 nM,58.7 nM 和 53.2 nM;kb NB 142-70 同时具有抗肿瘤活性。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.