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PKD

Protein kinase D (PKD) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G-protein-coupled receptor agonists and polypeptide growth factors. The protein kinase D (PKD) family of serine/threonine protein kinases has three members: PKD1, PKD2, PKD3. PKD1, the most studied member of the family, is increasingly implicated in the regulation of a complex array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis, and cancer. PKD mediates such a diverse array of normal and abnormal biological functions via dynamic changes in its spatial and temporal localization, combined with its distinct substrate specificity.

Protein kinase D (3)
产品名称 目录号 简述
CID 2011756 HY-13454

CID-2011756是细胞活性的ATP竞争性PKD1抑制剂。

CID755673 HY-12239

CID755673是高效选择性的PKD1抑制剂,IC50 of 值为182 nM.

kb NB 142-70 HY-15528

kb NB 142-70是PKD抑制剂,对PKD1,2和3的IC50分别为28.3,58.7和53.2 nM。

Tags: PKD 抑制 | PKD 蛋白 | PKD 抑制剂 | PKD FDA上市药物 | PKD 和癌症 | PKD 活性 | PKD 激活 | PKD 信号通路 | PKD 抑制剂筛选 | PKD 高通量筛选 | PKD 抑制剂临床 | PKD 抑制剂药物 | PKD 抑制剂综述 | PKD 抑制剂研发 | PKD 抑制剂供应商 | PKD 抑制剂分销商

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