1. Apoptosis
  2. PKD

PKD

PKD (Protein kinase D) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G-protein-coupled receptor agonists and polypeptide growth factors. PKD family of serine/threonine protein kinases has three members: PKD1, PKD2, PKD3. PKD1, the most studied member of the family, is increasingly implicated in the regulation of a complex array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis, and cancer. PKD mediates such a diverse array of normal and abnormal biological functions via dynamic changes in its spatial and temporal localization, combined with its distinct substrate specificity.

PKD 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-12239
    CID755673 Inhibitor 99.60%
    CID755673是高效选择性的PKD1抑制剂,IC50 of 值为182 nM.
  • HY-15528
    kb NB 142-70 Inhibitor 98.59%
    kb NB 142-70是PKD抑制剂,对PKD1,2和3的IC50分别为28.3,58.7和53.2 nM。
  • HY-16698
    kb-NB77-78 Inhibitor
    kb-NB77-78是CID797718 (一种PKD1抑制剂) 的类似物。
  • HY-13454
    CID 2011756 Inhibitor
    CID-2011756是细胞活性的ATP竞争性PKD1抑制剂。
  • HY-15698A
    CRT0066101 dihydrochloride Inhibitor
    CRT0066101 dihydrochloride是有效,选择性的 PKD 抑制剂,对PKD1,2和3的IC50值分别为1,2.5和2 nM。