1. MAPK/ERK Pathway
  2. MNK

MNK

Mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1 and MNK2) phosphorylate the oncogene eIF4E on serine 209. This phosphorylation has been reported to be required for its oncogenic activity. Eukaryotic initiation factor 4E (eIF4E) is a key component of the translational machinery and an important modulator of cell growth and proliferation. The activity of eIF4E is thought to be regulated by interaction with inhibitory binding proteins (4E-BPs) and phosphorylation by mitogen-activated protein (MAP) kinase-interacting kinase (MNK) on Ser209 in response to mitogens and cellular stress.

MNK 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-100022
    eFT508 Inhibitor 99.49%
    eFT508 是一种高效,高选择性,可口服的 MNK1MNK2 抑制剂,其 IC50 值均为 1-2 nM。
  • HY-10520
    CGP 57380 Inhibitor 98.48%
    CGP 57380 是一种细胞渗透的吡唑-嘧啶类化合物,为具有选择性的 Mnk1 抑制剂,IC50 值为 2.2 μM,但是对 p38,JNK1,ERK1/2,PKC 或 Src-like 激酶等没有抑制作用。
  • HY-16982
    Cercosporamide Inhibitor
    Cercosporamide是有效的Mnk1选择性抑制剂, 抑制eIF4E磷酸化, 具有抗白血病效应。
  • HY-112424
    ETC-206 Inhibitor
    ETC-206 是一种选择性 MNK1MNK2 抑制剂,IC50 分别为 64 nM 和 86 nM。
  • HY-112113
    SLV-2436 Inhibitor
    SLV-2436 是一种高效且 ATP 竞争性的 MNK1MNK2 抑制剂,IC50 分别为 10.8 nM 和 5.4 nM。
Isoform Specific Products

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