1. MAPK/ERK Pathway
  2. JNK

JNK

JNKs (c-Jun N-terminal kinases) belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines,ultraviolet irradiation, heat shock, and osmotic shock. JNKs play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinases, MKK4 and MKK7 and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases. Downstream molecules that are activated by JNK include c-Jun, ATF2, ELK1, SMAD4, p53 and HSF1. JNKs can associate with scaffold proteins JNK interacting proteins as well as their upstream kinases JNKK1 and JNKK2 following their activation. JNK activity regulates several important cellular functions including cell growth, differentiation, survival and apoptosis.

JNK Isoform Specific Products:

  • JNK1

  • JNK2

  • JNK3

  • JNK

JNK 相关产品 (20):

Cat. No. Product Name Effect Purity
  • HY-12041
    SP600125 Inhibitor 98.69%
    SP600125 是一种广谱 JNK 抑制剂,作用于 JNK1JNK2JNK3IC50 分别为 40 nM,40 nM 和 90 nM。
  • HY-18982
    Anisomycin Activator 98.03%
    Anisomycin 是一种有效的 JNK 激活剂。
  • HY-15495
    CC-930 Inhibitor 99.98%
    CC-930 是一种有效的 JNK1/JNK2/JNK3 抑制剂,IC50 值分别为 61/7/6 nM,常用于治疗纤维变性和发炎。
  • HY-13319
    JNK-IN-8 Inhibitor 99.83%
    JNK-IN-8 是一种有效的 JNK 抑制剂,抑制 JNK1JNK2JNK3IC50 分别为 4.7 nM,18.7 nM 和 1 nM。
  • HY-P0069
    D-JNKI-1 Inhibitor
    D-JNKI-1 是一种 JNK 抑制剂,能够有效抑制 JNK 的活性。
  • HY-N2149
    Tomatidine Inhibitor >98.0%
    Tomatidine 通过阻断 NF-κBJNK 信号发挥抗炎作用。
  • HY-N0431
    Astragaloside IV Inhibitor 99.15%
    Astragaloside IV 是从黄芪中分到的皂苷类物质,能够抑制 ERK1/2JNK 的激活,在乳腺癌细胞 MDA-MB-231 中,能够下调 (MMP)-2,(MMP)-9 的信号通路。
  • HY-11010
    AS601245 Inhibitor 99.67%
    AS601245 是一种 JNK 抑制剂,抑制 hJNK1hJNK2hJNK3IC50 分别为 150, 220 和 70 nM。
  • HY-15617
    JNK-IN-7 Inhibitor 98.39%
    JNK-IN-7 是一种有效的 JNK 抑制剂,抑制 JNK1JNK2JNK3IC50 分别为 1.5,2 和 0.7 nM。
  • HY-10366
    BI-78D3 Inhibitor 99.69%
    BI-78D3 是一种底物竞争性的 JNK 抑制剂,抑制 JNK 激酶活性,IC50 为 280 nM。
  • HY-13022
    CC-401 hydrochloride Inhibitor 99.45%
    CC-401 hydrochloride 是一种有效的 JNK 抑制剂,Ki 为 25 到 50 nM。
  • HY-15737
    DB07268 Inhibitor 98.62%
    DB07268 是一种有效的选择性 JNK1 抑制剂,IC50 值为 9 nM。
  • HY-14761
    AS 602801 Inhibitor 98.66%
    AS 602801 是一种ATP竞争性的 JNK 抑制剂,作用于 JNK1JNK2JNK3IC50 分别为 80 nM,90 nM 和 230 nM。
  • HY-N0044
    Ginsenoside Re Inhibitor 98.09%
    Ginsenoside Re 是一种 Panax notoginseng 提取物。 Ginsenoside Re 可降低 β-淀粉样蛋白 ()。Ginsenoside Re 还通过抑制 JNKNF-κB 发挥抗炎作用。
  • HY-12829
    SR-3306 Inhibitor
    SR-3306 是一种有效的可渗透脑的选择性 JNK 抑制剂。
  • HY-N3442
    Juglanin Activator >98.0%
    Juglanin 是一个 JNK 激活剂。
  • HY-13022A
    CC-401 Inhibitor
    CC-401是第二代ATP竞争性JNK抑制剂,具有抗肿瘤活性。
  • HY-15881
    TCS JNK 5a Inhibitor 98.91%
    TCS JNK 5a 是一种有效的 JNK3 抑制剂,pIC50 为 6.7。TCS JNK 5a 也抑制 JNK2pIC50为 6.5。
  • HY-100233
    IQ-1 Inhibitor 98.71%
    IQ-1 是一种 NF-κB/激活蛋白1 (AP-1) 抑制剂,IC50 为 2.3±0.41 μM。IQ-1 对三种 JNK 都具有高的结合亲和力 (Kd 值),对 JNK3JNK1JNK2Kd 值分别为 100 nM,240 nM 和 360 nM。
  • HY-N1504
    Loureirin B Inhibitor
    Loureirin B 是从剑叶龙血树中分离到的黄酮类化合物,为 PAI-1 的抑制剂,IC50 值为 26.10 μM;同时可以抑制 KATP,以及 ERKJNK 的磷酸化,具有抗糖尿病的功效。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

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