1. MAPK/ERK Pathway
  2. JNK

JNK

JNKs (c-Jun N-terminal kinases) belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines,ultraviolet irradiation, heat shock, and osmotic shock. JNKs play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinases, MKK4 and MKK7 and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases. Downstream molecules that are activated by JNK include c-Jun, ATF2, ELK1, SMAD4, p53 and HSF1. JNKs can associate with scaffold proteins JNK interacting proteins as well as their upstream kinases JNKK1 and JNKK2 following their activation. JNK activity regulates several important cellular functions including cell growth, differentiation, survival and apoptosis.

JNK 相关产品 (18):

Cat. No. Product Name Effect Purity
  • HY-12041
    SP600125 Inhibitor 98.69%
    SP600125 是一种广谱 JNK 抑制剂,作用于 JNK1JNK2JNK3IC50 分别为 40 nM,40 nM 和 90 nM。
  • HY-18982
    Anisomycin Activator 98.03%
    Anisomycin是一种吡咯烷抗生素, 抑制蛋白质合成, 也是有效的SAPKs/JNKs激活剂。
  • HY-15495
    CC-930 Inhibitor 99.98%
    CC-930 是一种有效的 JNK1/JNK2/JNK3 抑制剂,IC50 值分别为 61/7/6 nM,常用于治疗纤维变性和发炎。
  • HY-13319
    JNK-IN-8 Inhibitor 99.83%
    JNK-IN-8 是一种有效的 JNK 抑制剂,抑制 JNK1JNK2JNK3IC50 分别为 4.7 nM,18.7 nM 和 1 nM。
  • HY-P0069
    D-JNKI-1 Inhibitor
    D-JNKI-1 是一种 JNK 抑制剂,能够有效抑制 JNK 的活性。
  • HY-N0176
    Dihydroartemisinin Activator >99.0%
    Dihydroartemisinin是青蒿素的衍生物,在抗癌方面具有显著功效。
  • HY-15617
    JNK-IN-7 Inhibitor 98.39%
    JNK-IN-7 是一种有效的 JNK 抑制剂,抑制 JNK1JNK2JNK3IC50 分别为 1.5,2 和 0.7 nM。
  • HY-11010
    AS601245 Inhibitor 99.67%
    AS601245是JNK抑制剂 (hJNK1: IC50=150nM, hJNK2: IC50=220nM and hJNK3: IC50=70 nM), 具有神经保护特性。
  • HY-N0431
    Astragaloside IV Inhibitor 99.15%
    Astragaloside IV 是从黄芪中分到的皂苷类物质,能够抑制 ERK1/2JNK 的激活,在乳腺癌细胞 MDA-MB-231 中,能够下调 (MMP)-2,(MMP)-9 的信号通路。
  • HY-15737
    DB07268 Inhibitor 98.44%
    DB07268是JNK1抑制剂,IC50为9 nM。
  • HY-13022
    CC-401 hydrochloride Inhibitor 99.45%
    CC-401 hydrochloride 是一种有效的 JNK 抑制剂,Ki 为 25 到 50 nM。
  • HY-14761
    AS 602801 Inhibitor
    AS 602801 是一种ATP竞争性的 JNK 抑制剂,作用于 JNK1JNK2JNK3IC50 分别为 80 nM,90 nM 和 230 nM。
  • HY-15027
    5-Aminosalicylic acid Inhibitor 98.49%
    5-Aminosalicylic acid是抗炎化合物。
  • HY-12829
    SR-3306 Inhibitor
    SR-3306是脑渗透性JNK抑制剂。
  • HY-13022A
    CC-401 Inhibitor
    CC-401是第二代ATP竞争性JNK抑制剂,具有抗肿瘤活性。
  • HY-15881
    TCS JNK 5a Inhibitor 98.91%
    TCS JNK 5a(JNK Inhibitor IX)对JNK3,JNK2,JNK1和p38α的pIC50分别为6.7,6.5,<5.0和<4.8,对其它蛋白激酶则无明显活性。
  • HY-100233
    IQ-1S free acid Inhibitor
    IQ-1S(free acid)是JNK激酶的抑制剂,特别是JNK 3. 对于JNK1,2和3,Kd值分别是390,360和87 nM.
  • HY-10366
    BI-78D3 Inhibitor
    BI-78D3是一个竞争性的JNK抑制剂,IC50是280 nM.