1. Protein Tyrosine Kinase/RTK
  2. IGF-1R

IGF-1R

IGF-1R (Insulin-like growth factor 1 receptor) is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice carrying only one functional copy of IGF-1R are normal, but exhibit a ~15% decrease in body mass. The IGF-1R is implicated in several cancers, including breast, prostate, and lung cancers. In some instances its anti-apoptotic properties allow cancerous cells to resist the cytotoxicproperties of chemotherapeutic drugs or radiotherapy.

IGF-1R 相关产品 (14):

Cat. No. Product Name Effect Purity
  • HY-15656
    LDK378 Inhibitor 99.75%
    LDK378 是一种有效的特异性 ALK 抑制剂,IC50 为 0.2 nM。
  • HY-10191
    Linsitinib Inhibitor 99.69%
    Linsitinib 是一种选择性的 IGF-1R 抑制剂,IC50 值为 35 nM,也适度地作用于 InsRIC50 值为 75 nM;对 Abl,ALK,BTK,EGFR,FGFR1/2,PKA 等没有作用。
  • HY-50866
    NVP-AEW541 Inhibitor 98.76%
    NVP-AEW541 是一种有效的 IGF-1R 抑制剂,IC50 为 0.15 μM,也抑制 InsRIC50 为 0.14 μM。
  • HY-10200
    BMS-754807 Inhibitor 99.79%
    BMS-754807 是有效、可逆的胰岛素样生长因子1受体/胰岛素受体抑制剂,其 IC50 值分别为 1.8 和 1.7 nM,Ki 值均小于 2 nM;同时也抑制 Met,RON,TrkA,TrkB,AurA 和 AurB 的活性,其IC50 值分别为 6,44,7,4,9和 25 nM。
  • HY-15494
    AXL1717 Inhibitor 99.58%
    AXL1717 是一种有效的胰岛素样生长因子1型受体 (IGF-1R) 抑制剂,IC50 值为 1 nM。
  • HY-15656A
    LDK378 dihydrochloride Inhibitor 99.86%
    LDK378 2Hcl是ALK抑制剂,IC50为0.2 nM,比对IGF-1R和InsR的抑制性高40倍和35倍。
  • HY-10262
    BMS-536924 Inhibitor 98.73%
    BMS-536924是ATP竞争性IGF-1R/IR抑制剂, IC50分别为100 nM/73 nM。
  • HY-10253
    AG1024 Inhibitor 99.47%
    AG-1024 (Tyrphostin)能抑制IGF-1R自磷酸化,IC50为7 μM,而对IR的IC50则为57 μM。
  • HY-15609
    AZD-3463 Inhibitor 98.49%
    AZD-3463是ALK/IGF1R抑制剂。
  • HY-10252
    NVP-ADW742 Inhibitor 99.66%
    NVP-ADW742(ADW742; GSK 552602A )是IGF-1R选择性抑制剂,IC50为170nM,比对InsR的抑制性强16倍,对HER2,PDGFR,VEGFR-2,Bcr-Abl和c-Kit活性极低。
  • HY-15749
    XL228 Inhibitor 99.22%
    XL228是IGF1R,Aurora, FGFR1-3,ABL和SRC等蛋白激酶抑制剂,对Aurora A的IC50为3 nM,对Abl的Ki为5 nM。
  • HY-13020
    GSK1838705A Inhibitor 98.99%
    GSK1838705A是IGF-IR,InsR和ALK抑制剂,IC50分别为2.0,1.6和0.5 nM。
  • HY-13686
    PQ401 Inhibitor 99.86%
    PQ401是IGF1R阻断剂,能抑制IGF1R自磷酸化,IC50 < 1 uM。
  • HY-10524
    GSK1904529A Inhibitor 98.97%
    GSK1904529A是IGF-1R和IR的选择性抑制剂,IC50分别为27 nM和25 nM,对Akt1/2,Aurora A/B,B-Raf,CDK2,EGFR的抑制性相对较弱。