1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. FAAH


FAAH (Fatty acid amide hydrolase) is an integral membrane enzyme that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic or pharmacological inactivation of FAAH leads to analgesic, anti-inflammatory, anxiolytic, and antidepressant phenotypes in rodents without showing the undesirable side effects observed with direct cannabinoid receptor agonists, indicating that FAAH may represent an attractive therapeutic target for treatment of pain, inflammation, and other central nervous system disorders.

FAAH 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-14376
    PF-04457845 Inhibitor 99.09%
    PF-04457845 是一种高效选择性的 FAAH 抑制剂,作用于 hFAAHrFAAHIC50 分别为 7.2±0.63 nM 和 7.4±0.62 nM。
  • HY-19740
    BIA 10-2474 Inhibitor 98.82%
    BIA 10-2474是脂肪酸酰胺水解酶FAAH的抑制剂,对大鼠大脑不同区域的IC50值为50至70mg/kg。
  • HY-10865
    LY2183240 Inhibitor 99.74%
    LY2183240是高活性大麻素吸收阻断剂,IC50为270 pM,还能抑制脂肪酸酰胺水解酶(FAAH),IC50为12.4 nM。
  • HY-10864
    URB-597 Inhibitor 98.71%
    URB597是口服生物相容性的FAAH抑制剂,IC50为4.6 nM,对其它的cannabinoid-相关靶点无活性。
  • HY-14380
    PF-3845 Inhibitor 98.94%
    PF-3845 是选择性脂肪酰胺水解酶(FAAH)抑制剂,Ki为230nM,对FAAH2几乎无活性。
  • HY-15250
    JZL195 Inhibitor 99.31%
  • HY-19636
    JNJ-42165279 Inhibitor 99.96%
    JNJ-42165279是FAAH抑制剂, 抑制 hFAAH和 rFAAH, IC50分别为70±8 nM 和 313 ± 28 nM。
  • HY-14595
    Biochanin A Inhibitor 98.86%
    Biochanin A 是一种天然存在的脂肪酸酰胺水解酶 (FAAH) 抑制剂,抑制FAAH,作用于小鼠,大鼠,人 FAAH,IC50 分别为 1.8,1.4 和 2.4 μM。
  • HY-79511
    FAAH-IN-2 Inhibitor
  • HY-10862
    FAAH inhibitor 1 Inhibitor
    FAAH inhibitor 1是脂肪酸酰胺水解酶(FAAH)抑制剂,IC50为18 nM。