1. PI3K/Akt/mTOR
  2. PI4K

PI4K

The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi.

In mammals there are four different PI4K enzymes, two type II enzymes (PI4KIIα and PI4KIIβ) and two type III enzymes (PI4KIIIα and PI4KIIIβ). PI4KIIIβ plays key roles in mediating lipid transport, cytokinesis, maintaining lysosomal identity, and in tandem with Rab GTPases plays key roles in regulating membrane trafficking. PI4KIIIβ is critical for mediating viral replication of a number of RNA viruses through the generation of PI4P enriched viral replication platforms. Small molecule inhibitors of PI4KIIIβ are potent anti-viral agents. Development of PI4KIIIβ as an effective drug target for anti-viral therapeutics requires the generation of highly potent and specific inhibitors.

PI4K 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-12046
    PIK-93 Inhibitor 99.13%
    PIK-93 是一种合成的,有效的 PI4KIIIβ 抑制剂,IC50 值为 19 nM,同时可抑制 PI3Kα 的活性,IC50 值为 39 nM。
  • HY-15679
    PI4KIII beta inhibitor 3 Inhibitor 98.21%
    PI4KIII beta inhibitor 3 是一种新型高效的 PI4KIII beta 抑制剂,IC50 为 5.7 nM。
  • HY-100198
    PI4KIIIbeta-IN-10 Inhibitor 98.21%
    PI4KIIIbeta-IN-10是目前报道的最有力的PI4KIIIβ抑制剂 (IC50=3.6 nM)。
  • HY-19798
    PI4KIIIbeta-IN-9 Inhibitor
    PI4KIIIbeta-IN-9是一种强效PI4KIIIβ抑制剂 (IC50值为7 nM)。