1. PI3K/Akt/mTOR
  2. PI4K

PI4K

The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi.

In mammals there are four different PI4K enzymes, two type II enzymes (PI4KIIα and PI4KIIβ) and two type III enzymes (PI4KIIIα and PI4KIIIβ). PI4KIIIβ plays key roles in mediating lipid transport, cytokinesis, maintaining lysosomal identity, and in tandem with Rab GTPases plays key roles in regulating membrane trafficking. PI4KIIIβ is critical for mediating viral replication of a number of RNA viruses through the generation of PI4P enriched viral replication platforms. Small molecule inhibitors of PI4KIIIβ are potent anti-viral agents. Development of PI4KIIIβ as an effective drug target for anti-viral therapeutics requires the generation of highly potent and specific inhibitors.

PI4K 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-12046
    PIK-93 Inhibitor 99.13%
    PIK-93 是一种合成的,有效的 PI4KIIIβ 抑制剂,IC50 值为 19 nM,同时可抑制 PI3KγPI3Kα 的活性,IC50 值分别为 16 nM 和 39 nM。
  • HY-100198
    PI4KIIIbeta-IN-10 Inhibitor 98.21%
    PI4KIIIbeta-IN-10是目前报道的最有力的PI4KIIIβ抑制剂 (IC50=3.6 nM)。
  • HY-15679
    PI4KIII beta inhibitor 3 Inhibitor 98.21%
    PI4KIII beta inhibitor 3 是一种新型高效的 ΡΙ4ΚΙΙΙβ 抑制剂,IC50 为 5.7 nM。
  • HY-19798
    PI4KIIIbeta-IN-9 Inhibitor 98.16%
    PI4KIIIbeta-IN-9是一种强效PI4KIIIβ抑制剂 (IC50值为7 nM)。
  • HY-108313
    T-00127_HEV1 Inhibitor 99.97%
    T-00127_HEV1 是一个 phosphatidylinositol 4-kinase III beta (PI4KB) 抑制剂,其 IC50 值为 60 nM。
  • HY-18748
    BQR-695 Inhibitor
    BQR-695 是一种磷脂酰肌醇 4-激酶 (PI4K) 抑制剂,对于人类和疟原虫 PI4KIIIβ 的 IC50 值分别为 80 和 3.5 nM。