1. Autophagy
  2. ULK

ULK

ULK1, a serine/threonine protein kinase, is an enzyme that in humans is encoded by the ULK1 gene. ULK1 is essential for the initial stages of autophagy. ULK1 is an important protein in autophagy. It is part of the ULK1-complex, which is needed in early steps of autophagosome biogenesis. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.

ULK2 is essential for astrocyte transformation and tumor growth. ULK2 also inhibits the growth of glioma cells, which requires autophagy induction as kinase mutant of ULK2 fails to induce autophagy and inhibit growth. ULK2 and its homologue ULK1 are only down-regulated in all grades of glioma. Thus these results altogether suggest that inhibition of autophagy by ULK1/2 down-regulation is essential for glioma development.

ULK 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-16966
    SBI-0206965 Inhibitor 98.04%
    SBI-0206965是一种强效, 选择性和细胞渗透性自噬激酶ULK1抑制剂, 抑制ULK1和ULK2激酶活性, IC50值分别为108nM和711 nM。
  • HY-100006A
    MRT68921 hydrochloride Inhibitor 99.71%
    MRT68921盐酸盐是最有效的ULK1 和ULK2抑制剂, 抑制ULK1和ULK2, IC50分别为 2.9 nM和 1.1 nM。
  • HY-100006
    MRT68921 Inhibitor
    MRT68921是ULK1ULK2最有效的抑制剂,IC50值分别为2.9 nM和1.1 nM.