1. Signaling Pathways
  2. Cytoskeleton
  3. Clathrin

Clathrin (网格蛋白)

Clathrin

网格蛋白是一种位于细胞质中的笼状囊泡蛋白,用于膜运输。网格蛋白是经典内吞作用的分子支架,用于吸收细胞外物质,也是跨不同膜结构的细胞内运输载体,例如从高尔基体到内质网的运输。网格蛋白功能障碍可能导致神经退行性疾病、肌肉疾病或癌症。

Clathrin is the cytoplasma-located, cage-like vesicle proteins for membrane transport. Clathrin is the molecular scaffold of classical endocytosis for extracellular substances uptake, and the intracellular transport carrier across different membrane structures such as transport from the Golgi apparatus to the endoplasmic reticulum. Clathrin dysfunction could lead to neurodegenerative diseases, muscle diseases, or cancer[1].

Clathrin 相关产品 (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131683
    ES9-17 Inhibitor 99.87%
    ES9-17 是 ES9 (endosidin9) 的类似物,它是网格蛋白重链 (CHC) 的抑制剂。ES9-17 抑制网格蛋白介导的内吞作用 (CME),而 CME 是植物胞外环境中质膜蛋白和分子内化的主要途径。ES9-17 抑制转铁蛋白和 FM4-64 的摄取。ES9-17 还能抑制拟南芥 (Arabidopsis) 幼苗的根生长。
    ES9-17