1. Cell Cycle/DNA Damage
  2. DNA-PK


DNA-PKcs (DNA-dependent protein kinase, catalytic subunit) is an enzyme that in humans is encoded by the PRKDC gene. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. DNA-PKcs is the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase called DNA-PK. The second component is the autoimmune antigen Ku. On its own, DNA-PKcs is inactive and relies on Ku to direct it to DNA ends and trigger its kinase activity. DNA-PKcs is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Many proteins have been identified as substrates for the kinase activity of DNA-PK. Autophosphorylation of DNA-PKcs appears to play a key role in NHEJ and is thought to induce a conformational change that allows end processing enzymes to access the ends of the double-strand break. DNA-PK also cooperates with ATR and ATM to phosphorylate proteins involved in the DNA damage checkpoint.

DNA-PK 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-10197
    Wortmannin Inhibitor 99.65%
    Wortmannin 是一种多靶点抑制剂,抑制 PI3K 和 MLCK 活性,IC50 分别为 3 nM 和 200 nM。并有效抑制 DNA-PK 和 ATM,IC50 分别为 16 nM 和 150 nM。
  • HY-13003
    Torin 1 Inhibitor 99.16%
    Torin 1 是一种有效的 mTOR 抑制剂,能够抑制 mTORC1 和 mTORC2 的活性,IC50 值分别为 2 nM 和 10 nM。
  • HY-12513
    LY3023414 Inhibitor 99.70%
    LY3023414 有效且选择性地抑制 PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, mTORDNA-PKIC50 分别为 6.07 nM,77.6 nM,38 nM,23.8 nM,165 nM 和 4.24 nM。
  • HY-11006
    KU-57788 Inhibitor 98.74%
    KU-57788 是一种有效的,选择性的 DNA-PK 抑制剂,并且适度抑制 BRD4BRDTIC50 值分别为 13 nM,1 μM 和 3.5 μM;同时能够激活 CRISPR/Cas9
  • HY-13002
    Torin 2 Inhibitor 99.89%
    Torin 2 是一种 mTOR 抑制剂,抑制细胞内 mTOR 活性,EC50 为 0.25 nM,比作用于 PI3K (EC50: 200 nM) 选择性高 800 倍。
  • HY-15719
    NU 7026 Inhibitor 99.95%
    NU 7026 是一种新型特异性的 DNA-PK 抑制剂,IC50 为 0.23±0.01 μM,也抑制 PI3KIC50 为 13±3 μM。
  • HY-13281
    PIK-75 Inhibitor 99.91%
    PIK-75是p110α抑制剂,IC50为 5.8 nM,比对p110β的抑制性强200倍,还能抑制DNA-PK,IC50为2 nM。
  • HY-16962
    CC-115 Inhibitor
    CC-115 是一种有效的双重 mTORDNA-PK 抑制剂,IC50 分别为 21 nM 和 13 nM。
  • HY-101667
    LTURM34 Inhibitor 99.24%
    LTURM34是DNA-PK的特异抑制剂,IC50值为0.034 μM。
  • HY-16962A
    CC-115 hydrochloride Inhibitor
    CC-115 hydrochloride 是一种有效的双重 mTORDNA-PK 抑制剂,IC50 分别为 21 nM 和 13 nM。
  • HY-101146
    SF2523 Inhibitor 99.37%
    SF2523 是一种有效的选择性 PI3K 抑制剂,抑制 PI3KαPI3KγDNA-PK,BRD4 和 mTOR,IC50 分别为 34 nM,158 nM,9 nM,241 nM 和 280 nM。
  • HY-19341
    Compound 401 Inhibitor 99.88%
    Compound 401是一种合成的DNA-PK抑制剂 (IC50 = 0.28 μM)。