1. Apoptosis
  2. TNF-alpha

TNF-alpha

Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine. TNF-alpha can activate the NF-κB pathway by increasing the phosphorylation of IKK-α/β.

TNF-alpha is a negative regulator ofinsulin signal transduction. TNF-alpha is involved in regulating insulin resistance, obesity, as well as fatty acid (FA) and glucose metabolism. It has been confirmed that both adipose tissue and macrophages from activated adipose tissue secret TNF-alpha. The regulatory mechanisms of TNF-alpha on adipose tissue have been fully elucidated in mammals in the past decades. In addition, TNF-alpha is a limiting factor of lipid deposition in some fish species. TNF-alpha participates in regulating fat tissue mass in the gilthead sea bream (Sparusaurata L.), controlling adipose tissue lipid metabolism, and inhibiting the differentiation of adipocyte precursor cells in rainbow trout (Oncorhynchusmykiss). TNF-alpha inhibits the expression of GSK-3β and induces β-catenin expression. TNF-alpha inhibits the expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα), as well as the activity of lipoprotein lipase (LPL) and fatty acid synthetase (FAS). In addition, the level of triglyceride (TG), total cholesterol (TC), nonesterified fatty acid (NEFA), and glycerol is decreased by TNF-alpha treatment in the liver.

TNF-alpha 相关产品 (26):

Cat. No. Product Name Effect Purity
  • HY-A0003
    Lenalidomide Inhibitor 99.98%
    Lenalidomide 是一种有效的 TNF-α 抑制剂,具有抗血管增生作用。
  • HY-10984
    Pomalidomide Inhibitor >98.0%
    Pomalidomide 作用于 LPS 刺激的人 PBMC 细胞,抑制 TNF-α 释放,IC50 为 13 nM。
  • HY-15615A
    TIC10 Agonist 99.68%
    TIC10 是一种有效的 TRAIL 诱导剂,也抑制 AktERK 活性。
  • HY-14622
    Necrostatin 2 Inhibitor 99.89%
    Necrostatin 2 是一种有效的程序性坏死 (necroptosis) 抑制剂。作用于TNF-α处理的FADD缺陷型Jurkat T细胞,抑制程序性坏死,EC50 为 0.05 μM。
  • HY-A0003B
    Lenalidomide hemihydrate Inhibitor 99.82%
    Lenalidomide (Revlimid, CC-5013)半水合物是TNF-α分泌抑制剂,IC50为13 nM。
  • HY-N1949
    Homoplantaginin Inhibitor 99.61%
    Homoplantaginin是来自中药Salvia plebeia的具有抗炎和抗氧化活性的类黄酮。
  • HY-N0029
    Forsythoside B 99.63%
    Forsythoside B是传统中药植物独一味的叶子中分离的苯乙醇苷。独一味可用于治疗炎症疾病和促进血液循环。
  • HY-P9908
    Adalimumab Inhibitor
    Adalimumab 是一种人源的单克隆 IgG1 抗体,靶向肿瘤坏死因子α (TNF-α); MW:150 kDa。
  • HY-14622A
    Necrostatin 2 racemate Inhibitor 99.10%
    Necrostatin 2是高活性的坏死性凋亡抑制剂,EC50为50nM。
  • HY-32018
    Cot inhibitor-2 Inhibitor 99.20%
    Cot 抑制剂-2是COT/Tpl2抑制剂。
  • HY-100735
    C 87 Inhibitor >98.0%
    C87是一种新型小分子TNFα抑制剂; 高效抑制TNFα诱导的细胞毒性,IC50值为8.73 μM。
  • HY-N0724
    Mesaconitine Inhibitor 99.55%
    新乌头碱(Mesaconitine)是乌头属植物的主要活性成分,具有多种药学作用。
  • HY-N0297
    Sinensetin Inhibitor 99.22%
    Sinensetin是一个能够在水果中发现的甲基化黄酮,有很强的抗血管和抗炎症的能力.
  • HY-15615
    TIC10 isomer 99.61%
    TIC10(ONC201 isomer)是口服活性的稳定化合物,能抑制Akt和ERK,能透过血脑屏障,可诱导TRAIL。
  • HY-N2027
    Taurochenodeoxycholic acid Inhibitor 99.80%
    Taurochenodeoxycholic acid是动物胆汁酸的主要生物活性物质之一。
  • HY-19717
    DCVC Inhibitor 99.89%
    DCVC 能抑制病原刺激的TNF-α。
  • HY-32015
    Cot inhibitor-1 Inhibitor
    Cot 抑制剂-1是COT/Tpl2抑制剂。
  • HY-14622B
    Necrostatin 2 S enantiomer Inhibitor 98.73%
    Necrostatin 2是高活性的坏死性凋亡抑制剂,EC50为50nM。
  • HY-18377
    Bioymifi Activator
    Bioymifi是第一个新型TRAIL受体DR5小分子激动剂。
  • HY-N0619
    Mulberroside A Inhibitor 98.01%
    桑皮苷A (Mulberroside A) 是从桑树根皮的提取物中分离得到的一类化合物,具有抗酪氨酸酶活性,是很多美白化妆品的活性成分。