1. Apoptosis
  2. TNF Receptor

TNF Receptor

Tumor necrosis factor (TNF) is a major mediator of apoptosis as well as inflammation and immunity, and it has been implicated in the pathogenesis of a wide spectrum of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases.

TNF-α is a 17-kDa protein consisting of 157 amino acids that is a homotrimer in solution. In humans, the gene is mapped to chromosome 6. Its bioactivity is mainly regulated by soluble TNF-α–binding receptors. TNF-α is mainly produced by activated macrophages, T lymphocytes, and natural killer cells. Lower expression is known for a variety of other cells, including fibroblasts, smooth muscle cells, and tumor cells. In cells, TNF-α is synthesized as pro-TNF (26 kDa), which is membrane-bound and is released upon cleavage of its pro domain by TNF-converting enzyme (TACE).

Many of the TNF-induced cellular responses are mediated by either one of the two TNF receptors, TNF-R1 and TNF-R2, both of which belong to the TNF receptor super-family. In response to TNF treatment, the transcription factor NF-κB and MAP kinases, including ERK, p38 and JNK, are activated in most types of cells and, in some cases, apoptosis or necrosis could also be induced. However, induction of apoptosis or necrosis is mainly achieved through TNFR1, which is also known as a death receptor. Activation of the NF-κB and MAPKs plays an important role in the induction of many cytokines and immune-regulatory proteins and is pivotal for many inflammatory responses.

TNF Receptor 相关产品 (40):

Cat. No. Product Name Effect Purity
  • HY-A0003
    Lenalidomide Inhibitor 99.98%
    Lenalidomide 是一种有效的 TNF-α 抑制剂,具有抗血管增生作用。
  • HY-16046
    AP1903 Activator 99.05%
    AP1903 是一种同源二聚体,结合到 FKBP,诱导培养中的工程细胞系HT1080发凋亡和死亡,EC50 为 0.1 nM,这种作用具有剂量依赖性。AP1903 诱导 Fas 激活。Fas 受体也称为肿瘤坏死因子受体超家族成员 6 (TNFRSF6)。
  • HY-10984
    Pomalidomide Inhibitor 99.86%
    Pomalidomide 作用于 LPS 刺激的人 PBMC 细胞,抑制 TNF-α 释放,IC50 为 13 nM。
  • HY-N0822
    Shikonin Inhibitor 99.64%
    Shikonin 是 TMEM16A 氯化物通道的抑制剂,其 IC50 值为 6.5 μM。Shikonin 也是一种特异性的 PKM2 抑制剂,而且可以抑制肿瘤坏死因子-α (TNF-α),阻止核因子-κB (NF-κB) 通路的激活。
  • HY-13812
    QNZ Inhibitor 98.46%
    QNZ 强抑制 NF-κB 转录激活和 TNF-α 产生,IC50 分别为 11 和 7 nM。QNZ 是一种保护神经的钙池操纵的钙通道 (SOC) 抑制剂。
  • HY-110203
    R-7050 Antagonist 98.83%
    R-7050 是一种肿瘤坏死因子受体 (TNFR) 拮抗剂,对 TNFα 具有更高选择性。
  • HY-15615A
    TIC10 Agonist 99.68%
    TIC10 是一种有效的 TRAIL 诱导剂,也抑制 AktERK 活性。
  • HY-A0003B
    Lenalidomide hemihydrate Inhibitor 99.82%
    Lenalidomide (Revlimid, CC-5013)半水合物是TNF-α分泌抑制剂,IC50为13 nM。
  • HY-14622
    Necrostatin 2 Inhibitor 99.97%
    Necrostatin 2 是一种有效的程序性坏死 (necroptosis) 抑制剂。作用于TNF-α处理的FADD缺陷型Jurkat T细胞,抑制程序性坏死,EC50 为 0.05 μM。
  • HY-N0182
    Fisetin Inhibitor >98.0%
    Fisetin是一种在许多水果和蔬菜中发现的天然黄酮醇,具有多种益处,如抗氧化,抗癌,神经保护作用。
  • HY-14622A
    Necrostatin 2 racemate Inhibitor 99.10%
    Necrostatin 2是高活性的坏死性凋亡抑制剂,EC50为50nM。
  • HY-32018
    Cot inhibitor-2 Inhibitor 99.20%
    Cot 抑制剂-2是COT/Tpl2抑制剂。
  • HY-P0224
    N-Formyl-Met-Leu-Phe Inhibitor 99.46%
    N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) 是一种趋化肽和N-甲酰基肽受体 (FPR) 的特异性配体。报道显示N-Formyl-Met-Leu-Ph 可抑制 TNF-alpha 的分泌。
  • HY-N2027
    Taurochenodeoxycholic acid Inhibitor 99.80%
    Taurochenodeoxycholic acid是动物胆汁酸的主要生物活性物质之一。
  • HY-15643A
    LY 303511 hydrochloride Activator 98.41%
    LY 303511 hydrochloride 是 是 LY294002 的一种结构类似物,但 LY303511 不抑制 PI3K。LY303511 可增强 SHEP-1 神经母细胞瘤细胞的TRAIL 敏感性。LY303511 可逆地阻断 MIN6 胰岛瘤细胞中的 K+ 电流 (IC50=64.6±9.1 μM)。
  • HY-100735
    C 87 Inhibitor >98.0%
    C87是一种新型小分子TNFα抑制剂; 高效抑制TNFα诱导的细胞毒性,IC50值为8.73 μM。
  • HY-N0297
    Sinensetin Inhibitor 99.22%
    Sinensetin是一个能够在水果中发现的甲基化黄酮,有很强的抗血管和抗炎症的能力.
  • HY-A0203
    Pentosan Polysulfate >98.0%
    Pentosan Polysulfate是一种半合成药物,用于治疗包括血栓和间质性膀胱炎在内的多种症状。
  • HY-N0724
    Mesaconitine Inhibitor 99.55%
    新乌头碱(Mesaconitine)是乌头属植物的主要活性成分,具有多种药学作用。
  • HY-P9908
    Adalimumab Inhibitor 98.12%
    Adalimumab 是一种人源的单克隆 IgG1 抗体,靶向肿瘤坏死因子α (TNF-α)。
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