1. Apoptosis
  2. TNF-alpha

TNF-alpha

Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine. TNF-alpha can activate the NF-κB pathway by increasing the phosphorylation of IKK-α/β.

TNF-alpha is a negative regulator ofinsulin signal transduction. TNF-alpha is involved in regulating insulin resistance, obesity, as well as fatty acid (FA) and glucose metabolism. It has been confirmed that both adipose tissue and macrophages from activated adipose tissue secret TNF-alpha. The regulatory mechanisms of TNF-alpha on adipose tissue have been fully elucidated in mammals in the past decades. In addition, TNF-alpha is a limiting factor of lipid deposition in some fish species. TNF-alpha participates in regulating fat tissue mass in the gilthead sea bream (Sparusaurata L.), controlling adipose tissue lipid metabolism, and inhibiting the differentiation of adipocyte precursor cells in rainbow trout (Oncorhynchusmykiss). TNF-alpha inhibits the expression of GSK-3β and induces β-catenin expression. TNF-alpha inhibits the expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα), as well as the activity of lipoprotein lipase (LPL) and fatty acid synthetase (FAS). In addition, the level of triglyceride (TG), total cholesterol (TC), nonesterified fatty acid (NEFA), and glycerol is decreased by TNF-alpha treatment in the liver.

TNF-alpha 相关产品 (32):

Cat. No. Product Name Effect Purity
  • HY-A0003
    Lenalidomide Inhibitor 99.98%
    Lenalidomide 是一种有效的 TNF-α 抑制剂,具有抗血管增生作用。
  • HY-10984
    Pomalidomide Inhibitor >99.0%
    Pomalidomide 作用于 LPS 刺激的人 PBMC 细胞,抑制 TNF-α 释放,IC50 为 13 nM。
  • HY-15615A
    TIC10 Agonist 99.68%
    TIC10 是一种有效的 TRAIL 诱导剂,也抑制 AktERK 活性。
  • HY-A0003B
    Lenalidomide hemihydrate Inhibitor 99.82%
    Lenalidomide (Revlimid, CC-5013)半水合物是TNF-α分泌抑制剂,IC50为13 nM。
  • HY-14622
    Necrostatin 2 Inhibitor 99.89%
    Necrostatin 2 是一种有效的程序性坏死 (necroptosis) 抑制剂。作用于TNF-α处理的FADD缺陷型Jurkat T细胞,抑制程序性坏死,EC50 为 0.05 μM。
  • HY-A0203
    Pentosan Polysulfate >98.0%
    Pentosan polysulfate是有效,选择性的 HIV 抑制剂。
  • HY-N0182
    Fisetin >98.0%
    Fisetin是一种在许多水果和蔬菜中发现的天然黄酮醇,具有多种益处,如抗氧化,抗癌,神经保护作用。
  • HY-107390
    AX-024 Inhibitor >98.0%
    AX-024 是一种细胞因子释放抑制剂,可以有效抑制白细胞介素-6 (IL-6),肿瘤坏死因子-α (TNFα),干扰素-γ (IFN-γ),IL-10IL-17A 的产生。
  • HY-14622A
    Necrostatin 2 racemate Inhibitor 99.10%
    Necrostatin 2是高活性的坏死性凋亡抑制剂,EC50为50nM。
  • HY-15643A
    LY 303511 hydrochloride Activator 98.41%
    LY 303511 hydrochloride 是 LY294002 的一种非活性类似物。LY303511 通过 H2O2-MAPK 激活和上调死亡受体来增强 SHEP-1 成神经细胞瘤细胞的 TRAIL 敏感性。
  • HY-32018
    Cot inhibitor-2 Inhibitor 99.20%
    Cot 抑制剂-2是COT/Tpl2抑制剂。
  • HY-100735
    C 87 Inhibitor >98.0%
    C87是一种新型小分子TNFα抑制剂; 高效抑制TNFα诱导的细胞毒性,IC50值为8.73 μM。
  • HY-N0724
    Mesaconitine Inhibitor 99.55%
    新乌头碱(Mesaconitine)是乌头属植物的主要活性成分,具有多种药学作用。
  • HY-N2027
    Taurochenodeoxycholic acid Inhibitor 99.80%
    Taurochenodeoxycholic acid是动物胆汁酸的主要生物活性物质之一。
  • HY-N0297
    Sinensetin Inhibitor 99.22%
    Sinensetin是一个能够在水果中发现的甲基化黄酮,有很强的抗血管和抗炎症的能力.
  • HY-19717
    DCVC Inhibitor 99.89%
    DCVC 能抑制病原刺激的TNF-α。
  • HY-14622B
    Necrostatin 2 S enantiomer Inhibitor 98.73%
    Necrostatin 2是高活性的坏死性凋亡抑制剂,EC50为50nM。
  • HY-N1949
    Homoplantaginin Inhibitor 99.81%
    Homoplantaginin是来自中药Salvia plebeia的具有抗炎和抗氧化活性的类黄酮。
  • HY-107390A
    AX-024 hydrochloride Inhibitor 99.29%
    AX-024 hydrochloride 是一种细胞因子释放抑制剂,可以有效抑制白细胞介素-6 (IL-6),肿瘤坏死因子-α (TNFα),干扰素-γ (IFN-γ),IL-10IL-17A 的产生。
  • HY-N0619
    Mulberroside A Inhibitor 98.01%
    桑皮苷A (Mulberroside A) 是从桑树根皮的提取物中分离得到的一类化合物,具有抗酪氨酸酶活性,是很多美白化妆品的活性成分。