1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. COMT

COMT

Catechol O-methyltransferase (COMT) is a ubiquitous bisubstrate magnesium-dependent enzyme found in plants, animals and microorganisms. COMT catalyses the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to one of the hydroxyl oxygen atoms (preferentially the 3-hydroxyl) in a catechol substrate. Physiological substrates of COMT are catecholamine neurotransmitters such as dopamine, noradrenaline, adrenaline and their metabolites. COMT also methylates catecholic steroids such as 2-hydroxyestradiol as well as a range of other catecholic compounds including neuroactive drugs such as L-dopa, α-methyldopa and isoproterenol. COMT inhibition is a means of treating Parkinson’s disease, schizophrenia and depression. There are two isoforms of human COMT: soluble cytoplasmic COMT (S-COMT), which is mainly intracellular, and a membrane-bound form (MB-COMT), which has a single-span helix contained within a 50 amino acid extension at the N-terminus.

COMT is an enzyme that plays a major role in catechol neurotransmitter deactivation. Inhibition of COMT can increase neurotransmitter levels, which provides a means of treatment for Parkinson’s disease, schizophrenia and depression.

COMT 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-17406
    Tolcapone Inhibitor 99.44%
    Tolcapone(Ro 40-7592)是口服活性的外周和中枢COMT抑制剂。
  • HY-14896
    Opicapone Inhibitor
    Opicapone 是一种有效的儿茶酚-O-甲基转移酶e (COMT)抑制剂。Opicapone 降低细胞ATP含量,IC50为 98 μM。
  • HY-14280
    Entacapone Inhibitor 99.63%
    Entacapone是特异的外周活性的邻苯二酚-O-甲基转移酶(COMT)抑制剂,IC50为151 nM。
  • HY-14280A
    Entacapone sodium salt Inhibitor
    Entacapone是特异的儿茶酚-o-甲基转移酶(COMT)抑制剂,IC50为151 nM。