1. Neuronal Signaling
  2. Amyloid-β

Amyloid-β

Amyloid-β (Aβ) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of theamyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield Aβ. Amyloid-β molecules can aggregate to form flexible soluble oligomers which may exist in several forms. Amyloid-β peptide is due to overproduction of Aβ and/or the failure of clearance mechanisms. Amyloid-β self-aggregates into oligomers, which can be of various sizes, and forms diffuse and neuritic plaques in the parenchyma and blood vessels. Amyloid-β oligomers and plaques are potent synaptotoxins, block proteasome function, inhibit mitochondrial activity, alter intracellular Ca2+levels and stimulate inflammatory processes. Loss of the normal physiological functions of Aβ is also thought to contribute to neuronal dysfunction.

Amyloid-β 相关产品 (16):

Cat. No. Product Name Effect Purity
  • HY-B0988
    Deferoxamine mesylate Inhibitor >98.0%
    Deferoxamine mesylate 是一种铁离子螯合剂,能够有效减少氧化应激和神经元的死亡。
  • HY-19370
    FPS-ZM1 Inhibitor 99.31%
    FPS-ZM1是高亲和力的RAGE特异性抑制剂,Ki值为25 nM。
  • HY-10009
    Semagacestat Inhibitor 98.90%
    Semagacestat 是一种 γ-secretase 抑制剂,抑制 β-amyloid (Aβ42),Aβ38Aβ40IC50 分别为 10.9,12 和 12.1 nM。也抑制 NotchIC50 为 14.1 nM。
  • HY-N0009
    Geniposide Antagonist 99.52%
    Geniposide是从栀子花中提取的环烯醚萜甙; 具有多种生物活性,例如抗糖尿病,抗氧化,抗增殖和神经保护活性。
  • HY-15374
    Frentizole Inhibitor 98.98%
    Frentizole是FDA批准的免疫抑制剂,是新型的Aβ-ABAD相互作用抑制剂。
  • HY-15560B
    Hoechst 34580 tetrahydrochloride Inhibitor
    Hoechst 34580 tetrahydrochloride是一种细胞渗透性的荧光染料,用于DNA和核染色。
  • HY-P0128
    Amyloid beta-peptide(25-35)
    Amyloid beta-peptide(25-35) 是阿尔茨海默氏淀粉样蛋白β肽的Aβ(25-35) 片段,在培养细胞中显示出神经毒性活性。
  • HY-18292
    ARN2966 Inhibitor 98.39%
    ARN2966是一个高效的,针对APP表达的转录后调节剂,降低APP的表达从而是Aβ的量降低。
  • HY-14602
    Tramiprosate Inhibitor >98.0%
    Tramiprosate是一个小的,能够口服的化合物,可以结合可溶性Aβ,减少淀粉样蛋白聚合和随后的沉积。
  • HY-14533
    K 01-162 Inhibitor
    K 01-162 (K162) 结合到AβO (β-amyloid)将其破坏, EC50为80 nM。
  • HY-N0615
    Notoginsenoside R1 Inhibitor
    三七皂苷R1 (Notoginsenoside R1) 三七的主要活性成分,据报道有神经保护、抗高血压的作用。
  • HY-19771
    amyloid P-IN-1 Inhibitor
    amyloid P-IN-1有利于在疾病或功能失调的治疗中消耗血清淀粉样蛋白P组件(SAP),包括淀粉样变,阿尔茨海默病,2型糖尿病和关节炎。
  • HY-15560
    Hoechst 34580 Inhibitor
    Hoechst 34580 是一种细胞渗透性的荧光染料,用于 DNA 和核染色。
  • HY-50900
    gamma-Secretase Modulators Inhibitor
    gamma-Secretase Modulators (Amyloid-β production inhibitor)是淀粉状蛋白β生成抑制剂,可作用于阿尔茨海默病。
  • HY-N0695
    Schisantherin B Inhibitor
    五味子酯乙 (Schisantherin B)是一种天然产物。
  • HY-B0491A
    Carbazochrome sodium sulfonate Activator
    Carbazochrome(AC-17)磺酸钠为抗出血剂。