1. Cell Cycle/DNA Damage
  2. G-quadruplex

G-quadruplex

G-quadruplexes (G-tetrads or G4-DNA) are nucleic acid sequences that are rich in guanine and are capable of forming a four-stranded structure. Four guanine bases can associate through Hoogsteen hydrogen bonding to form a square planar structure called a guanine tetrad, and two or more guanine tetrads can stack on top of each other to form a G-quadruplex. The quadruplex structure is further stabilized by the presence of a cation, especially potassium, which sits in a central channel between each pair of tetrads.They can be formed of DNA, RNA, LNA, and PNA, and may be intramolecular, bimolecular or tetramolecular. Depending on the direction of the strands or parts of a strand that form the tetrads, structures may be described as parallel or antiparallel.

G-quadruplex 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-16291
    APTO-253 Activator
    APTO-253 是一种 Kruppel-like factor 4 诱导剂,同时可稳定 Gquadruplex 结构,具有抗癌活性。
  • HY-15176A
    Pyridostatin hydrochloride Activator >98.0%
    Pyridostatin hydrochloride 是一种 G-quadruplexe 稳定剂,Kd 值为 490 nM。
  • HY-15594A
    Phen-DC3 Trifluoromethanesulfonate Inhibitor 98.66%
    Phen-DC3 Trifluoromethanesulfonate 是一个 G4 特异性配体,可以抑制解旋酶 FANCJDinGIC50s 值分别为 65±6 和 50±10 nM。
  • HY-15595A
    360A iodide Activator >98.0%
    360A iodide 是一种 G-四联体 (G-quadruplex) 的稳定剂,同时可抑制端粒酶 (telomerase) 的活性,在 TRAP-G4 实验中,IC50 值为 300 nM。
  • HY-15176
    Pyridostatin Activator
    Pyridostatin 是一种 G-quadruplexe 稳定剂,Kd 值为 490 nM。
  • HY-15595
    360A Activator
    360A 是一种 G-四联体 (G-quadruplex) 的稳定剂,同时可抑制端粒酶 (telomerase) 的活性,在 TRAP-G4 实验中,IC50 值为 300 nM。
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