1. Protein Tyrosine Kinase/RTK
  2. FAK

FAK

FAK (Focal Adhesion Kinase or PTK2) is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes. It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility. FAK is found concentrated in the focal adhesions that form among cells attaching to extracellular matrix constituents. FAK is a member of the FAK subfamily of protein tyrosine kinases that included PYK2 but lacks significant sequence similarity to kinases from other subfamilies. With the exception of certain types of blood cells, most cells express FAK. FAK tyrosine kinase activity can be activated, which plays a key important early step in cell migration. FAK activity elicits intracellular signal transduction pathways that promote the turn-over of cell contacts with the extracellular matrix, promoting cell migration.

FAK 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-13917
    PND-1186 Inhibitor 99.93%
    PND-1186 可逆地抑制 FAK 活性,IC50 为 1.5 nM。
  • HY-12289
    Defactinib Inhibitor 99.94%
    Defactinib 是一种新型 FAK 抑制剂,抑制 FAK 在 Tyr397 位点磷酸化,这种作用具有时间和剂量依赖性。
  • HY-100498
    GSK2256098 Inhibitor 99.35%
    GSK2256098 是一种选择性 FAK 激酶抑制剂,可抑制胰腺癌细胞的生长和存活。
  • HY-13203
    NVP-TAE 226 Inhibitor 99.73%
    NVP-TAE 226 是一种双重酪氨酸激酶抑制剂,作用于 FAKIGF-IRIC50 分别为 5.5 nM 和 0.14 μM。
  • HY-10461
    PF-573228 Inhibitor 98.72%
    PF-573228是有效的和选择性的FAK抑制剂,对FAK纯化重组催化片段的IC50值为4 nM。
  • HY-10460
    PF-431396 Inhibitor 99.40%
    PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4.
  • HY-10459
    PF-562271 Inhibitor 99.36%
    PF-562271 是有效的ATP竞争性的可逆 FAKPyk2 激酶抑制剂,IC50 分别为 1.5 和 13 nM。
  • HY-15841
    CEP-37440 Inhibitor 99.87%
    CEP-37440是新型FAK和ALK双重抑制剂,IC50分别为2.3 nM和120 nM。
  • HY-12444
    Y15 Inhibitor >98.0%
    Y15 特异性抑制 FAK 自磷酸化。
  • HY-10458
    PF-562271 besylate Inhibitor 98.31%
    PF-562271 besylate 是一种有效的,ATP 竞争性的,可逆的 FAKPyk2 kinase 抑制剂,IC50 值分别为 1.5 nM 和 13 nM,对其活性是对CDK酶以外的其他酶的 100 多倍。
  • HY-19376
    NAMI-A Inhibitor >98.0%
    NAMI-A是一个能够有选择活性的阻碍肿瘤转移,抑制粘附和迁移。
  • HY-12289A
    Defactinib hydrochloride Inhibitor
    Defactinib盐酸盐(VS-6063; PF-04554878)是一高效FAK激酶磷酸化抑制剂,能通过AKY依赖性通路客服YB1介导的paclitaxel耐受。