1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Mps1

Mps1

Monopolar spindle 1 (Mps1), also known as TTK, is a serine threonine kinase, which ensures proper biorientation of sister chromatids on the mitotic spindle by the activation of the spindle assembly checkpoint (SAC). Mps1 has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of chromosomes to daughter cells.

Mps1 is a dual specificity protein kinase that is essential for the bipolar attachment of chromosomes to the mitotic spindle and for maintaining the spindle assembly checkpoint until all chromosomes are properly attached. Mps1 is expressed at high levels during mitosis and is abundantly expressed in cancer cells. Disruption of Mps1 function induces aneuploidy and cell death.

Mps1 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-13298
    Mps1-IN-1 Inhibitor 99.89%
    Mps1-IN-1是Mps1高效选择性抑制剂,IC50值为367nM,对其他352种激酶抑制力基本无,特别是Alk和Ltk。
  • HY-14710
    AZ3146 Inhibitor 99.64%
    AZ3146 是一种有效的选择性的 Mps1 抑制剂,作用于 Mps1CatIC50 为 35 nM。
  • HY-101340
    CFI-402257 Inhibitor 99.52%
    CFI-402257是高度选选择性,具有口服活性的TTKMps1抑制剂,Ki值分别为0.1 nM和0.09 nM。
  • HY-12858
    BAY 1161909 Inhibitor
    BAY 1161909 抑制Mps1激酶活性, 10 μM ATP条件下测得IC50 < 1 nM, 2 mM ATP条件下, 测得IC50 < 1.9 nM。
  • HY-12859
    BAY1217389 Inhibitor >98.0%
    BAY 1217389是具有高效性和选择性的(MPS1)激酶抑制剂,IC50值小于10 nM。
  • HY-12382
    NMS-P715 Inhibitor 99.46%
    NMS-P715是首个高选择性、ATP竞争性和口服活性的MPS1小分子抑制剂,IC50值为8nM,能选择性抑制癌细胞增生,对正常细胞几乎无影响。
  • HY-12660
    MPI-0479605 Inhibitor
    MPI-0479605是有效的, ATP竞争性的Mps1选择性抑制剂, IC50 为1.8 nM, 比作用于其他激酶选择性高40多倍。
  • HY-13994
    Mps1-IN-2 Inhibitor 98.06%
    Mps1-IN-2是Mps1抑制剂,IC50为145 nM。
  • HY-14712
    NMS-P715 analog Inhibitor
    NMS-P715 analog是NMS-P715的类似物,NMS-P715是首个高效、ATP竞争性Mps1抑制剂(IC50值为8nM)。
  • HY-12401
    Mps1-IN-3 Inhibitor
    Mps1-IN-3是Mps1高效选择性抑制剂,IC50值为50 nM。