1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Mps1

Mps1

Monopolar spindle 1 (Mps1), also known as TTK, is a serine threonine kinase, which ensures proper biorientation of sister chromatids on the mitotic spindle by the activation of the spindle assembly checkpoint (SAC). Mps1 has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of chromosomes to daughter cells.

Mps1 is a dual specificity protein kinase that is essential for the bipolar attachment of chromosomes to the mitotic spindle and for maintaining the spindle assembly checkpoint until all chromosomes are properly attached. Mps1 is expressed at high levels during mitosis and is abundantly expressed in cancer cells. Disruption of Mps1 function induces aneuploidy and cell death.

Mps1 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-101340
    CFI-402257 Inhibitor 99.52%
    CFI-402257是高度选选择性,具有口服活性的TTKMps1抑制剂,Ki值分别为0.1 nM和0.09 nM。
  • HY-12859
    BAY1217389 Inhibitor >98.0%
    BAY 1217389是具有高效性和选择性的(MPS1)激酶抑制剂,IC50值小于10 nM。
  • HY-13298
    Mps1-IN-1 Inhibitor 99.66%
    Mps1-IN-1 是一种有效的,选择性的,ATP 竞争性的 Mps1 抑制剂,IC50Kd 值分别为 367 nM 和 27 nM。
  • HY-12858
    BAY 1161909 Inhibitor >98.0%
    BAY 1161909 是一种有效的 Mps1 抑制剂,IC50 值 < 1 nM。
  • HY-12382
    NMS-P715 Inhibitor 99.46%
    NMS-P715 是一种选择性的,ATP 竞争性的 MPS1 抑制剂,IC50 值为 182 nM。
  • HY-14710
    AZ3146 Inhibitor 99.64%
    AZ3146 是一种有效的选择性的 Mps1 抑制剂,作用于 Mps1CatIC50 为 35 nM。
  • HY-12660
    MPI-0479605 Inhibitor 99.77%
    MPI-0479605 是一种有效的,选择性的,ATP 竞争性的 Mps1 抑制剂,IC50 值为 1.8 nM。
  • HY-13994
    Mps1-IN-2 Inhibitor 98.06%
    Mps1-IN-2 是一种有效的,选择性的,ATP 竞争性的 Mps1/Plk1 双重抑制剂,对 Mps1 的 IC50Kd 值分别为 145 nM 和 12 nM,对 Plk1 的 Kd 值为 61 nM。
  • HY-14712
    NMS-P715 analog Inhibitor
    NMS-P715 analog 是一种有效的 MPS1 抑制剂,IC50 值为 84 nM。
  • HY-12401
    Mps1-IN-3 Inhibitor
    Mps1-IN-3 是一种有效的,选择性的 MPS1 抑制剂,IC50 值为 50 nM。