1. Anti-infection
  2. Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal 相关产品 (83):

Cat. No. Product Name Effect Purity
  • HY-12320
    Cycloheximide Inhibitor 99.17%
    Cycloheximide 是真核生物中蛋白质生物合成的抑制剂,抑制蛋白合成和RNA合成,IC50 分别为 532.5 nM 和 2880 nM。
  • HY-B0221
    Amphotericin B Inhibitor >98.00%
    Amphotericin B 是一种两亲的多烯类抗生素,能够使含有麦角固醇的细胞膜渗透化。
  • HY-B0490
    Hygromycin B Inhibitor >98.00%
    Hygromycin B是对原核和真核细胞有活性的氨基糖苷类抗生素。
  • HY-16321
    Micafungin sodium Inhibitor >98.0%
    Micafungin sodium 是一种 1,3-β-D-葡聚糖的合成抑制剂,有抗真菌功效。
  • HY-17409
    Nystatin Inhibitor
    Nystatin 是一种多烯抗真菌药,能够抗酵母菌和支原体。
  • HY-B0105
    Ketoconazole Inhibitor 99.76%
    Ketoconazole是咪唑类抗真菌剂,是经典的CYP3A4抑制剂,也是 CYP24A1的抑制剂。
  • HY-17373
    Posaconazole Inhibitor 99.78%
    Posaconazole 是一种广谱的,二代三唑类物质,具有抗真菌作用。
  • HY-13553
    Anidulafungin Inhibitor 99.22%
    Anidulafungin 是一种新型的半合成棘球白素,具有抗真菌 (antifungal) 效力。
  • HY-17006
    Caspofungin Acetate Inhibitor 99.72%
    Caspofungin Acetate 是一种抗真菌药,能够非竞争性地抑制1,3-β-d葡聚糖合酶的合成。
  • HY-17514
    Itraconazole Inhibitor 99.91%
    Itraconazole是抗真菌剂。
  • HY-17395A
    Terbinafine Inhibitor 99.98%
    Terbinafine是治疗真菌感染的抗真菌药物。它是来自念珠菌属的角鲨烯环氧化酶有效的非竞争性抑制剂, Ki值为30 nM。
  • HY-12772
    Itraconazole metabolite Hydroxy Itraconazole Inhibitor >98.0%
    Itraconazole metabolite Hydroxy Itraconazole 是 Itraconazole (ITZ) 的活性代谢物,Itraconazole 是一种三唑类抗真菌剂。
  • HY-14283
    Luliconazole Inhibitor 99.84%
    Luliconazole(NND 502)是抗真菌剂,可用于局部的脚癣治疗。
  • HY-B0139
    Flucytosine Inhibitor 99.88%
    Flucytosine(5-Fluorocytosine, 5-FC, Ancobon)是抗真菌化合物。
  • HY-76200
    Voriconazole Inhibitor 99.59%
    Voriconazole(UK-109496)是第二代三唑类抗真菌化合物,可作用于严重的真菌感染。
  • HY-13557
    Ascomycin Inhibitor 98.04%
    Ascomycin(Immunomycin, FR-900520, FK520)是tacrolimus (FK506)的类似物,具有很强的免疫抑制剂。
  • HY-B0454A
    Miconazole nitrate Inhibitor 99.71%
    Miconazole硝酸盐是咪唑类抗真菌剂。
  • HY-B0450
    Ciclopirox Inhibitor
    Ciclopirox (Penlac)是合成的抗真菌化合物。
  • HY-10882
    Clotrimazole Inhibitor 99.71%
    Clotrimazole是咪唑衍生物,有抗真菌活性,是P450抑制剂。
  • HY-B0101
    Fluconazole Inhibitor
    Fluconazole是抗真菌化合物,可用于表面和全身性的真菌感染。