1. GPCR/G Protein
  2. EBI2/GPR183

EBI2/GPR183

The Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183) is an orphan member of the 7TM receptor family A. EBI2 is a constitutively active seven-transmembrane receptor. EBI2 has been placed in varying 7TM receptor subgroups by different phylogenetic analyses as being a target of peptide or lipid ligands. EBI2 constitutively activates extracellular signal-regulated kinase (ERK) in a pertussis toxin-insensitive manner. EBI2 is up-regulated up to 200-fold in B cells following EBV infection.

EBI2 activation stimulates immune cell migration and has been genetically linked to autoimmune diseases including type 1 diabetes. Small molecule modulators of EBI2 can be useful for probing the function of the receptor and its relevance to human diseases.

EBI2/GPR183 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-101192
    GSK682753A Agonist 98.47%
    GSK682753A是EB病毒诱导受体2 (EBI2) 的反向激动剂, IC50值为53.6 nM。
  • HY-12336
    NIBR189 Antagonist 99.24%
    NIBR189是一个EBI2(GPR183)小分子拮抗剂,IC50值为11nM。