1. Protein Tyrosine Kinase/RTK
  2. Ack1

Ack1

Ack1 (Activated CDC42 kinase 1) is an enzyme that in humans is encoded by the TNK2 gene. Ack1 binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). Ack1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Ack1 is a survival kinase and shown to be associated with tumor cell survival, proliferation, hormone-resistance and radiation resistance. Ack1 has emerged as a new cancer target and multiple small molecule inhibitors have been reported.

Ack1 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-15290
    AIM-100 Inhibitor 99.98%
    AIM-100是Ack1抑制剂,IC50为24 nM。
  • HY-12331
    KRCA-0008 Inhibitor 98.07%
    KRCA-0008是一个高效选择性ALK/Ack1抑制剂,对ALK和Ack1的IC50值分别为12nM和4nM,具有非hERG依赖性药物特征。