1. Epigenetics
  2. MicroRNA

MicroRNA

MiRNAs are 21-25 nucleotide RNAs that negatively regulate gene expression through translational repression or cleavage of a target mRNA. They are transcribed as precursors that are processed by the nucleases Drosha and Dicer.

Small molecules targeting the secondary structure of precursor miRNAs can be more selective modulators of function than oligonucleotides that target RNA sequence.

MicroRNAs (miRNAs) and promoter hypermethylation are vital epigenetic mechanisms for transcriptional inactivation of tumor suppressor.

MicroRNA 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-15843
    MIR96-IN-1 Inhibitor 99.30%
    MIR96-IN-1选择性抑制微小RNA-96的生物合成, 上调蛋白靶点 (FOXO1) 且诱导癌细胞凋亡。
  • HY-19731
    SID 3712249 Inhibitor 99.84%
    SID3712249 (MIR-544 Inhibitor 1) 是微小RNA-544 (miR-544) 的生物合成抑制剂。
  • HY-15861
    Targapremir-210 Inhibitor
    Targapremir-210 是有效的 miR-210 抑制剂,MDA-MB-231 细胞系的 IC50 值为 200 nM。Targapremir-210 通过和 miR-210 的发夹前体结构结合,进而抑制 miRNA 的成熟。
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