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HBV

Hepatitis B virus, abbreviated HBV, is a species of the genus Orthohepadnavirus, which is likewise a part of the Hepadnaviridae family of viruses. HBV causes the disease hepatitis B. The hepatitis B virus is classified as the type species of the Orthohepadnavirus, which contains three other species: the Ground squirrel hepatitis virus, Woodchuck hepatitis virus, and theWoolly monkey hepatitis B virus. The genus is classified as part of the Hepadnaviridae family. HBV is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes present on its envelope proteins, and into eight genotypes (A–H) according to overall nucleotide sequence variation of the genome. The genotypes have a distinct geographical distribution and are used in tracing the evolution and transmission of the virus. Differences between genotypes affect the disease severity, course and likelihood of complications, and response to treatment and possibly vaccination.

Hepatitis B virus (15)
产品名称 目录号 简述
Adefovir dipivoxil HY-B0255

Adefovir Dipivoxil (阿德福韦酯) 可阻断HBV逆转录酶。

Bay 41-4109 HY-100029

BAY 41-4109是人乙型肝炎病毒HBV的有效抑制剂,IC50值为53 nM。

Bay 41-4109 less active enantiomer HY-100029B

Bay 41-4109 less active enantiomer 是比BAY 41-4109活性低的对应体。BAY 41-4109是人乙型肝炎病毒HBV的有效抑制剂,IC50值为53 nM。

Bay 41-4109 racemate HY-100029A

BAY 41-4109 racemate是BAY 41-4109的消旋体。BAY 41-4109是人乙型肝炎病毒HBV的有效抑制剂,IC50值为53 nM。

Bicyclol HY-B0766

Bicyclol(SY 801)是可口服的抗HBV,HCV化合物。

Clevudine HY-13859

Clevudine能抗乙肝病毒。

Entecavir HY-13623

Entecavir(SQ 34676; BMS 200475)是有选择且有效地HBV抑制剂。在HepG2细胞中的EC50值为3.75 nM。

Entecavir monohydrate HY-13623A

Entecavir monohydrate(SQ 34676; BMS 200475)是有选择且有效地HBV抑制剂。在HepG2细胞中的EC50值为3.75 nM。

Helioxanthin 8-1 HY-16680

Helioxanthin 8-1是helioxanthin类似物,具有抗HBV/HCV/HSV-1/HIV的活性,EC50分别为>5/10/1.4/15 uM。

Helioxanthin derivative 5-4-2 HY-16679

Helioxanthin derivative 5-4-2是helioxanthin类似物,具有较高的体外抗HBV活性,EC50为0.08 uM。

Lagociclovir HY-14844

Lagociclovir(MIV-210)是3_acute_-fluoro-2_acute_,3_acute_-dideoxyguanosine的前体化合物,具有抗HBV和口服活性。

Merimepodib HY-13986

Merimepodib 是次黄嘌呤核苷磷酸脱氢酶 (Inosine monophosphate dehydrogenase) 的非竞争性抑制剂。

Osalmid HY-B2116

Osalmid是核糖核苷酸还原酶小亚基M2(RRM2)的靶向化合物; 抑制核糖核苷酸还原酶活性的IC50值为8.23 μM。

Squalamine HY-16468

Squalamine(MSI-1256)是具有广谱抗病毒活性化的化合物。

Telbivudine HY-B0017

Telbivudine (替比夫定) 是特异的HBV复制抑制剂。

Tags: HBV 抑制 | HBV 蛋白 | HBV 抑制剂 | HBV FDA上市药物 | HBV 和癌症 | HBV 活性 | HBV 激活 | HBV 信号通路 | HBV 抑制剂筛选 | HBV 高通量筛选 | HBV 抑制剂临床 | HBV 抑制剂药物 | HBV 抑制剂综述 | HBV 抑制剂研发 | HBV 抑制剂供应商 | HBV 抑制剂分销商

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