1. Anti-infection
  2. HIV


HIV (Human immunodeficiency virus) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

HIV 相关产品 (83):

Cat. No. Product Name Effect Purity
  • HY-13238
    Dolutegravir Inhibitor 99.54%
    Dolutegravir 抑制 HIV-1 整合酶催化的链转移,IC50 为 2.7 nM。
  • HY-13004
    Maraviroc Inhibitor 99.34%
    Maraviroc 是一种选择性的 CCR5 拮抗剂,抑制 MIP-1α (IC50,3.3 nM),MIP-1β (IC50,7.2 nM) 和 RANTES (IC50,5.2 nM) 结合到表达 CCR5 的 HEK-293 细胞膜。
  • HY-14740
    Elvitegravir Inhibitor 99.78%
    Elvitegravir 是一种 HIV integrase 抑制剂,作用于 HIV-1IIIB,HIV-2EHO 和 HIV-2RODIC50 分别为 0.7 nM,2.8 nM 和 1.4 nM。
  • HY-17367A
    Atazanavir sulfate Inhibitor 99.64%
  • HY-13782
    Tenofovir Disoproxil Fumarate Inhibitor 99.46%
    Tenofovir Disoproxil Fumarate 是核苷酸逆转录酶抑制剂 (nucleotide reverse transcriptase inhibitor),用于治疗艾滋病和慢性乙型肝炎。
  • HY-B2226
    Sodium copper chlorophyllin Inhibitor
    Sodium copper chlorophyllin 对流感病毒和 HIV 发挥抗病毒活性,其 IC50s 值都是 50 到 100 μM。
  • HY-A0203
    Pentosan Polysulfate Inhibitor
    Pentosan polysulfate是有效,选择性的 HIV 抑制剂。
  • HY-102014
    RN-18 Antagonist 99.01%
    RN-18是HIV-1病毒感染因子 ( HIV-1 Vif) 的拮抗剂,在非允许细胞 H9 中的 IC50 为6 μM。
  • HY-15148
    Tipranavir Inhibitor 99.54%
    Tipranavir 有效抑制 HIV-1 蛋白酶 酶活性和二聚化,对抗多种蛋白酶抑制剂(PI)的HIV-1分离株具有有效的活性,IC50 为 66-410 nM。
  • HY-15457
    Triciribine Inhibitor 99.20%
    Triciribine 是一种 DNA 合成 (DNA synthesis)抑制剂,也抑制 AktHIV-1/2IC50 分别为 130 nM 和 0.02-0.46 μM。
  • HY-17427
    Emtricitabine Inhibitor 99.60%
    Emtricitabine是高效选择性的核苷逆转录酶(NRTI)和人类免疫缺陷病毒1型(HIV-1)抑制剂, 在PBMC细胞中抑制 NRTI的EC50值为0.01 µM。
  • HY-13685
    Miltefosine Inhibitor >98.0%
    Miltefosine 是一种 PI3K/Akt 抑制剂,大大减少 HIV-1 从病毒感染的巨噬细胞产生。
  • HY-90001
    Ritonavir Inhibitor 99.55%
    Ritonavir 是一种 HIV 蛋白酶抑制剂,能够抗 HIV 感染,治疗艾滋病。
  • HY-10572
    Efavirenz Inhibitor 99.69%
    Efavirenz 是一种有效的野生型 HIV-1 RT 抑制剂,Ki 为 2.93 nM,抑制 HIV-1 复制,IC95 为 1.5 nM。
  • HY-10571A
    Delavirdine mesylate Inhibitor 98.07%
  • HY-B0250
    Lamivudine Inhibitor 99.64%
    Lamivudine为核苷类似物,是逆转录酶抑制剂,IC50为2.7 mM。
  • HY-13910
    Tenofovir Inhibitor 99.77%
    Tenofovir 是一种用于治疗艾滋病毒和慢性乙型肝炎的核苷酸逆转录酶抑制剂。
  • HY-18595
    BI 224436 Inhibitor 98.17%
    BI 224436是一种新型的HIV-1非催化性位点整合酶抑制剂,对HIV-1实验室菌株的EC50值小于15 nM。
  • HY-17041
    Darunavir Ethanolate Inhibitor 99.73%
    Darunavir ethanolate (TMC114 ethanolate) 是一种用于治疗和预防HIV/AIDS的HIV蛋白酶抑制剂。对野生型HIV-1蛋白酶的Ki值为1 nM。
  • HY-17423
    Abacavir Inhibitor 98.17%