1. Anti-infection
  2. HIV

HIV

HIV (Human immunodeficiency virus) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

HIV 相关产品 (115):

Cat. No. Product Name Effect Purity
  • HY-13004
    Maraviroc Inhibitor 99.71%
    Maraviroc是选择性的CCR5拮抗剂,具有抑制 HIV 的活性。
  • HY-13238
    Dolutegravir Inhibitor 99.54%
    Dolutegravir是第二代HIV整合酶链转移抑制剂 (INSTI),IC50 为 2.7 nM。
  • HY-14882
    Cenicriviroc Inhibitor
    Cenicriviroc 是一种可口服的 CCR2/CCR5 双重拮抗剂,同时可抑制 HIV-1 和 HIV-2,具有显著的抗炎、抗感染的功效。
  • HY-90001
    Ritonavir Inhibitor 99.68%
    Ritonavir是用于治疗HIV感染和AIDS的 HIV蛋白酶的抑制剂。
  • HY-17367A
    Atazanavir sulfate Inhibitor 99.64%
    Atazanavir硫酸盐是HIV-1蛋白酶高活性抑制剂。
  • HY-W013332A
    3-Deazaadenosine hydrochloride Inhibitor 98.06%
    3-Deazaadenosine (hydrochloride) 是一种 S-腺苷高半胱氨酸水解酶 (S-adenosylhomocysteine hydrolase) 抑制剂,Ki 值为 3.9 µM;3-Deazaadenosine (hydrochloride) 具有抗炎、抗增殖、抗 HIV 等活性。
  • HY-P1355A
    Cyclosporin A-Derivative 1 Free base Inhibitor
    Cyclosporin A-Derivative 1 (Free base) 是亲环蛋白抑制剂,具有抗病毒活性。可抑制 HCVHIV
  • HY-13750
    Ebselen Inhibitor 99.89%
    Ebselen是HIV-1复制的小分子抑制剂, 是一种抗氧化药物。
  • HY-13782
    Tenofovir Disoproxil Fumarate Inhibitor 99.80%
    Tenofovir Disoproxil Fumarate是用于治疗 HIV 和慢性乙型肝炎核苷酸逆转录酶抑制剂。
  • HY-B0250
    Lamivudine Inhibitor 99.64%
    Lamivudine是核苷逆转录酶抑制剂 (NRTIs)。 Lamivudine可以抑制 HIV逆转录酶1和2 以及乙型肝炎病毒的逆转录酶
  • HY-15457
    Triciribine Inhibitor 99.20%
    Triciribine 是一种 DNA 合成 (DNA synthesis) 抑制剂,也抑制 AktHIV-1/2IC50 分别为 130 nM 和 0.02-0.46 μM。
  • HY-10353A
    Raltegravir potassium salt Inhibitor 99.96%
    Raltegravir potassium salt 是一种有效的 integrase 抑制剂,用于治疗 HIV 感染。
  • HY-15148
    Tipranavir Inhibitor 99.13%
    Tipranavir 有效抑制 HIV-1 蛋白酶 酶活性和二聚化,对抗多种蛋白酶抑制剂(PI)的HIV-1分离株具有有效的活性,IC50 为 66-410 nM。
  • HY-14740
    Elvitegravir Inhibitor 99.92%
    Elvitegravir 是一种 HIV integrase 抑制剂,作用于 HIV-1IIIB,HIV-2EHO 和 HIV-2RODIC50 分别为 0.7 nM,2.8 nM 和 1.4 nM。
  • HY-10572
    Efavirenz Inhibitor 99.99%
    Efavirenz 是一种有效的野生型 HIV-1 RT 抑制剂,Ki 为 2.93 nM,抑制 HIV-1 复制,IC95 为 1.5 nM。
  • HY-10571A
    Delavirdine mesylate Inhibitor 98.07%
    Delavirdine mesylate是有效的非核苷 HIV-1 逆转录酶抑制剂 (NNRTI)
  • HY-17007
    Saquinavir Inhibitor 99.91%
    Saquinavir(Ro 31-8959)是HIV蛋白酶抑制剂。
  • HY-17605
    Bictegravir Inhibitor 98.27%
    Bictegravir 是一种新型,有效的 HIV-1 整合酶抑制剂,其 IC50 值为 7.5 nM。
  • HY-13406
    TAK-779 Inhibitor 99.73%
    TAK-779 是一种有效的,选择性的,非肽类 CCR5CXCR3 拮抗剂,对 CCR5Ki 值为 1.1 nM,同时可以有效地,选择性地抑制 R5 HIV-1,在 MAGI-CCR5 细胞中,EC50EC90 值分别为 1.2 nM 和 5.7 nM。
  • HY-10529
    Betulinic acid Inhibitor 98.58%
    Betulinic acid 是一种天然的五环三萜类化合物,为真核细胞拓扑异构酶 I (topoisomerase I) 的抑制剂,IC50 值为 5 μM,具有抗炎,抗疟疾,抗艾滋病和抗肿瘤等活性。
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