首页 产品 化合物库 服务 Kit 关于我们 联系我们

信号通路

在线客服 在线询单 如何订购 促销产品 销售网络 定制服务

在线询价

温馨提示:客服在线时为9:00-18:00,
其他时间可发邮件至sales@medchemexpress.cn,我们会尽快回复您。

HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

Human immunodeficiency virus (75)
产品名称 目录号 简述
(Z)-Mutagenic Impurity of Tenofovir Disoproxil HY-100079A

(Z)-Mutagenic Impurity of Tenofovir Disoproxil is a mutagenic impurity in tenofovir disoproxil fumarate.

(±)-BI-D HY-18601

(_plusmn_)-BI-D是HIV整合酶(integrase)变构抑制剂,作用于整合酶与LEDGF/p75结合部位。

Abacavir HY-17423

Abacavir (阿巴卡韦) 是强力的核苷类似物,为逆转录酶抑制剂。

AMD 3465 HY-15971A

AMD 3465(GENZ-644494)是CXCR4拮抗剂,比AMD 3100的亲和力高8倍,能抑制SDF-1α配体结合,Ki为41.7 nM。

AMD 3465 hexahydrobromide HY-15971

AMD 3465 6HBr(GENZ-644494)是CXCR4拮抗剂,亲和性比AMD 3100高8倍,能抑制SDF-1_alpha_配体结合,Ki为41.7 nM。

Amprenavir HY-17430

Amprenavir (Agenerase)是HIV蛋白酶抑制剂,Ki为0.6 nM。

Atazanavir HY-17367

Atazanavir(BMS-232632)是HIV-1蛋白酶高活性抑制剂。

Atazanavir sulfate HY-17367A

Atazanavir sulfate (硫酸阿扎那韦) 是HIV-1蛋白酶高活性抑制剂。

Bevirimat HY-N0842

Bevirimat(YK FH312; FH11327; MPC-4326)是HIV-1病毒颗粒成熟抑制剂。

BI 224436 HY-18595

BI 224436是新型HIV整合酶(integrase)抑制剂,对HIV-1毒株的抗病毒EC50值小于15nM,细胞毒性低。

BMS-378806 HY-14134

BMS-806 (BMS 378806)是gp120/CD4抑制剂,IC50为5 nM。

BMS-538203 HY-11019

BMS-538203是高效的HIV整合酶抑制剂。

BMS-626529 HY-15440

BMS-626529是HIV-1 gp120抑制剂,能阻止其与CD4_addition_ T细胞的结合。

BMS-663068 HY-15440A

BMS-663068是BMS-626529的原药,能结合gp120,抑制HIV-1与细胞CD4受体的结合。

BMS-663068 Tris HY-15440B

BMS-663068是HIV-1附着抑制剂。

BMS-707035 HY-13269

BMS-707035是HIV-1整合酶(IN)抑制剂,IC50为15 nM。

CDK9-IN-1 HY-13231

CDK9-IN-1是新型CDK9抑制剂,有抗HIV活性。

Celgosivir hydrochloride HY-16134A

Celgosivir hydrochloride (MDL 28574A) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay.

D77 HY-18666

D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

Dapivirine HY-14266

Dapivirine(TMC 120, TMC 120 R147681)是HIV非核苷逆转录酶抑制剂(NNRTI),IC50为24 nM,能抑制包括NNRTI抗性的各种HIV-1毒株。

Tags: HIV 抑制 | HIV 蛋白 | HIV 抑制剂 | HIV FDA上市药物 | HIV 和癌症 | HIV 活性 | HIV 激活 | HIV 信号通路 | HIV 抑制剂筛选 | HIV 高通量筛选 | HIV 抑制剂临床 | HIV 抑制剂药物 | HIV 抑制剂综述 | HIV 抑制剂研发 | HIV 抑制剂供应商 | HIV 抑制剂分销商

SiteMap

MCE所有的产品和服务只应用于科学研究,我们不提供产品和服务给任何个人。

Copyright © 2013-2014 MedChemexpress All Rights Reserved 沪ICP备15051369号-1