1. Anti-infection
  2. HIV

HIV

HIV (Human immunodeficiency virus) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

HIV 相关产品 (102):

Cat. No. Product Name Effect Purity
  • HY-13004
    Maraviroc Inhibitor 99.71%
    Maraviroc 是一种选择性的 CCR5 拮抗剂,抑制 MIP-1α (IC50,3.3 nM),MIP-1β (IC50,7.2 nM) 和 RANTES (IC50,5.2 nM) 结合到表达 CCR5 的 HEK-293 细胞膜。
  • HY-13238
    Dolutegravir Inhibitor 99.54%
    Dolutegravir 抑制 HIV-1 整合酶催化的链转移,IC50 为 2.7 nM。
  • HY-90001
    Ritonavir Inhibitor 99.68%
    Ritonavir 是一种 HIV 蛋白酶抑制剂,能够抗 HIV 感染,治疗艾滋病。
  • HY-17367A
    Atazanavir sulfate Inhibitor 99.64%
    Atazanavir硫酸盐是HIV-1蛋白酶高活性抑制剂。
  • HY-14740
    Elvitegravir Inhibitor 99.92%
    Elvitegravir 是一种 HIV integrase 抑制剂,作用于 HIV-1IIIB,HIV-2EHO 和 HIV-2RODIC50 分别为 0.7 nM,2.8 nM 和 1.4 nM。
  • HY-100870
    ABX464 Inhibitor 99.81%
    ABX464 是一种有效的抗 HIV 剂。ABX464 作用于受刺激的外周血单个核细胞 (PBMCs),抑制 HIV-1 复制,IC50 为 0.1 μM 至 0.5 μM。
  • HY-104012
    MK-8591 Inhibitor
    MK-8591 是一种核苷逆转录酶 (reverse transcriptase) 抑制剂,具有抗 HIV-1 活性,对 HIV-1 (WT),HIV-1 (M184V),HIV-1 (MDR) 的 EC50 值分别为 0.068 nM,3.1 nM 和 0.15 nM。
  • HY-108820
    HIV-1 integrase inhibitor 4 Inhibitor
    HIV-1 integrase inhibitor 4 是一种 HIV-1 整合酶链转移 (INST) 抑制剂,其 IC50 值为 3.7 nM。
  • HY-13782
    Tenofovir Disoproxil Fumarate Inhibitor 99.80%
    Tenofovir Disoproxil Fumarate 是核苷酸逆转录酶抑制剂 (nucleotide reverse transcriptase inhibitor),用于治疗艾滋病和慢性乙型肝炎。
  • HY-15457
    Triciribine Inhibitor 99.20%
    Triciribine 是一种 DNA 合成 (DNA synthesis) 抑制剂,也抑制 AktHIV-1/2IC50 分别为 130 nM 和 0.02-0.46 μM。
  • HY-15148
    Tipranavir Inhibitor 99.13%
    Tipranavir 有效抑制 HIV-1 蛋白酶 酶活性和二聚化,对抗多种蛋白酶抑制剂(PI)的HIV-1分离株具有有效的活性,IC50 为 66-410 nM。
  • HY-10571A
    Delavirdine mesylate Inhibitor 98.07%
    Delavirdine(U90152)甲磺酸盐是非核苷类逆转录酶抑制剂(NNRTI)。
  • HY-10353A
    Raltegravir potassium salt Inhibitor 99.65%
    Raltegravir potassium salt 是一种有效的 integrase 抑制剂,用于治疗 HIV 感染。
  • HY-13750
    Ebselen Inhibitor 99.89%
    Ebselen是HIV-1复制的小分子抑制剂, 是一种抗氧化药物。
  • HY-B0250
    Lamivudine Inhibitor 99.64%
    Lamivudine为核苷类似物,是逆转录酶抑制剂,IC50为2.7 mM。
  • HY-13685
    Miltefosine Inhibitor >98.0%
    Miltefosine 是一种 Akt 抑制剂,大大减少 HIV-1 从病毒感染的巨噬细胞产生。
  • HY-10572
    Efavirenz Inhibitor 99.99%
    Efavirenz 是一种有效的野生型 HIV-1 RT 抑制剂,Ki 为 2.93 nM,抑制 HIV-1 复制,IC95 为 1.5 nM。
  • HY-13406
    TAK-779 Inhibitor 99.73%
    TAK-779是高活性非肽类CCR5选择性拮抗剂,IC50为1.4 nM,还能抑制HIV-1的Ba-L株在MAGI-CCR5和PBMC中的复制,EC50 分别为1.2和3.7 nM。
  • HY-15592
    Cabotegravir Inhibitor 99.85%
    Cabotegravir是一种有效的HIV整合酶抑制剂, 用于治疗和预防艾滋病毒感染, Cabotegravir抑制OAT1 (IC50为0.81 μM) 和OAT3 (IC50为0.41 μM)。
  • HY-17007
    Saquinavir Inhibitor 99.91%
    Saquinavir(Ro 31-8959)是HIV蛋白酶抑制剂。
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