1. Apoptosis
  2. c-Myc


c-Myc is the master transcription factor for cell proliferation and is involved in numeroushematological and solidcancers.

Proto-oncogene c-Myc, encoding one of the most important transcription factors, plays a pivotal role in tumor initiation and progression. c-Myc regulates hundreds of disparate target genes that participate numerous biological effects, such as cell proliferation, apoptosis, differentiation, and stem cell self-renewal. c-Myc is one of the four factors used in reprogramming somatic cells to induce pluripotent stem (iPS) cells and is implicated in maintaining cancer stem-like cells (CSCs).

The transcription factor c-Myc is a key mediator of the Notch signaling–regulated T cell differentiation. In a well-established in vitro differentiation model of T lymphocytes from hematopoietic stem cells, Notch1 and 4 directly promotes c-Myc expression; dominant-negative (DN) c-Myc inhibits early T cell differentiation. Moreover, the c-Myc expression activated by Notch signaling increases the expression of survivin, an inhibitor of apoptosis (IAP) protein.

c-Myc gene, as a transcription factor of hTERT, is over expressed in a variety of tumors.c-Myc and hTERT expression in local recurrent gastric cancer tissues is much higher than in primary gastric cancer tissues at the protein and mRNA levels.

c-Myc 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-12702
    10058-F4 Inhibitor 98.03%
    10058-F4 是一种 c-Myc 的抑制剂,能够抑制 c-Myc-Max 的相互作用,阻止 c-Myc 目的基因表达的转录激活。
  • HY-100015
    Mivebresib Inhibitor 99.28%
  • HY-19735
    KJ Pyr 9 Inhibitor 98.98%
    KJ Pyr 9 是一种新型 MYC 抑制剂。体外实验中, KJ Pyr 9 抑制 MYC 的 Kd 值为 6.5±1.0 nM。
  • HY-N0822
    Shikonin Inhibitor 99.64%
    Shikonin是一个TMEM16A chloride 通道的抑制剂,IC50值是6.5 uM.。
  • HY-100996
    10074-G5 Inhibitor
    10074-G5是c-Myc-Max二聚化抑制剂,IC50值为146 μM。
  • HY-100669
    Mycro 3 Inhibitor 98.63%
    Mycro 3 是一种有效的选择性 c-Myc 抑制剂。