1. Apoptosis
  2. c-Myc

c-Myc

c-Myc is the master transcription factor for cell proliferation and is involved in numeroushematological and solidcancers.

Proto-oncogene c-Myc, encoding one of the most important transcription factors, plays a pivotal role in tumor initiation and progression. c-Myc regulates hundreds of disparate target genes that participate numerous biological effects, such as cell proliferation, apoptosis, differentiation, and stem cell self-renewal. c-Myc is one of the four factors used in reprogramming somatic cells to induce pluripotent stem (iPS) cells and is implicated in maintaining cancer stem-like cells (CSCs).

The transcription factor c-Myc is a key mediator of the Notch signaling–regulated T cell differentiation. In a well-established in vitro differentiation model of T lymphocytes from hematopoietic stem cells, Notch1 and 4 directly promotes c-Myc expression; dominant-negative (DN) c-Myc inhibits early T cell differentiation. Moreover, the c-Myc expression activated by Notch signaling increases the expression of survivin, an inhibitor of apoptosis (IAP) protein.

c-Myc gene, as a transcription factor of hTERT, is over expressed in a variety of tumors.c-Myc and hTERT expression in local recurrent gastric cancer tissues is much higher than in primary gastric cancer tissues at the protein and mRNA levels.

c-Myc 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-12702
    10058-F4 Inhibitor 98.03%
    10058-F4 是一种 c-Myc 的抑制剂,能够抑制 c-Myc-Max 的相互作用,阻止 c-Myc 目的基因表达的转录激活。
  • HY-100015
    Mivebresib Inhibitor 99.28%
    Mivebresib是BET家族的抑制剂,能够扰乱关键的转录程序在体内或者体外推动前列腺癌增长引起强的抗肿瘤特性,也是MYC和TMPRSS2-ETS的抑制剂。
  • HY-19735
    KJ Pyr 9 Inhibitor 98.98%
    KJ Pyr 9 是一种新型 MYC 抑制剂。体外实验中, KJ Pyr 9 抑制 MYC 的 Kd 值为 6.5±1.0 nM。
  • HY-N0822
    Shikonin Inhibitor 99.64%
    Shikonin是一个TMEM16A chloride 通道的抑制剂,IC50值是6.5 uM.。
  • HY-100996
    10074-G5 Inhibitor
    10074-G5是c-Myc-Max二聚化抑制剂,IC50值为146 μM。
  • HY-100669
    Mycro 3 Inhibitor 98.63%
    Mycro 3 是一种有效的选择性 c-Myc 抑制剂。