1. Cell Cycle/DNA Damage
  2. Microtubule/Tubulin


Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Microtubule/Tubulin 相关产品 (83):

Cat. No. Product Name Effect Purity
  • HY-B0015
    Paclitaxel Inhibitor 99.64%
    Paclitaxel 是一种有效的抗癌剂,能够促进微管 (microtubule) 聚合,改变细胞分裂和增殖所需的微管动力学。
  • HY-B0011
    Docetaxel Inhibitor 99.93%
    Docetaxel 是一种半合成的 taxane类似物,用作微管 (microtubule) 稳定剂。
  • HY-13520
    Nocodazole Inhibitor 99.05%
    Nocodazole 是一种快速可逆的 microtubule 聚合抑制剂,也能够有效抑制ABL,ABL(E255K) 和 ABL(T315I) 的活性,IC50 值分别为 0.21 μM,0.53 μM 和 0.64 μM;同时可以增强 CRISPR/Cas9 的活性。
  • HY-15162
    Monomethyl auristatin E Inhibitor 99.94%
    Monomethyl auristatin E 是一种有效的抗有丝分裂制剂,通过阻滞微管蛋白 (tubulin) 的聚合来抑制细胞分裂;同时也为抗体药物偶联细胞毒素 (ADC Cytotoxin)。
  • HY-N0488
    Vincristine sulfate Inhibitor 99.51%
    Vincristine sulfate 是一种微管聚合抑制剂,能够与微管蛋白结合,IC50 值为 32 μM。
  • HY-N0227
    7-epi-Taxol Inhibitor 99.75%
    7-epi-Taxol 是 taxol 的活性代谢物,在抑制细胞增殖及微管 (microtubule) 解离,诱导微管聚合等方面与 taxol 作用相当。
  • HY-15575
    VcMMAE Inhibitor 99.89%
    VcMMAE 是 antibody-drug conjugate (ADC) 的一部分, 由肽段 valine-citrulline 和抗有丝分裂剂单甲基阿司他丁 (MMAE) 连接而成。
  • HY-19792
    Mertansine Inhibitor 98.74%
  • HY-16569
    Colchicine Inhibitor 99.56%
    Colchicine 是一种 tubulin 抑制剂及微管 microtubule干扰剂。Colchicine诱导细胞凋亡。
  • HY-15162A
    D8-MMAE Inhibitor 98.31%
    D8-MMAE 是 MMAE 的氘代形式。MMAE 抑制微管蛋白的聚合。
  • HY-13442A
    Eribulin mesylate Inhibitor 99.64%
    Eribulin (E7389; ER-086526)甲磺酸盐是软海绵素 B 的类似物,通过结合微管蛋白和微管,抑制癌细胞的增殖。
  • HY-12033
    2-Methoxyestradiol Inhibitor 99.54%
    2-Methoxyestradiol 是一种 microtubuleHIF-1 抑制剂,在秋水仙碱位点或附近结合到 tubulin,且抑制微管聚合,通过干扰正常微管功能而发挥作用。
  • HY-15278
    Epothilone D Inhibitor 99.93%
    Epothilone D 是一种有效的微管 (microtubule) 稳定剂。
  • HY-17418
    Vinblastine Inhibitor >98.0%
    Vinblastine是一种针对各种癌症类型的有细胞毒性的生物碱。 长春花碱可抑制微管的形成,抑制nAChR的IC50值为8.9 μM。
  • HY-17029
    Epothilone B Inhibitor 99.88%
    Epothilone B 是一种微管 microtubule (MT)靶向试剂,EC0.01 为 1.8 μM。
  • HY-12053A
    Vinorelbine ditartrate Inhibitor 99.62%
    Vinorelbine ditartrate 是一种抗有丝分裂剂,能够抑制 Hela 细胞的增殖,IC50值为 1.25 nM。
  • HY-15459
    Cabazitaxel Inhibitor 99.19%
    Cabazitaxel 是天然紫杉烷脱乙酰基巴卡丁III的半合成衍生物,具有显著的抗肿瘤功效。
  • HY-13780
    Vinblastine sulfate Inhibitor 99.87%
    Vinblastine sulfate是一种针对各种癌症类型的有细胞毒性的生物碱。 长春花碱可抑制微管的形成,抑制nAChR的IC50值为8.9 μM。
  • HY-15578
    McMMAF Inhibitor 99.47%
    Mc-MMAF是由高效微管抑制剂Monomethyl auristatin F (MMAF) 与保护基团maleimidocaproyl偶联而成。MMAF(一甲基澳瑞他汀F)为抗微管蛋白化合物,能通过阻断微管聚合抑制细胞分裂,较MMAE毒性低,可用于抗体偶联药物(ADC)。
  • HY-15584
    Taltobulin Inhibitor 99.90%
    Taltobulin (HTI-286; SPA-110)是Hemiasterlin类似物,微管蛋白抑制剂和抗体药物偶连体毒素组分(ADCs cytotoxin)。
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