1. Vitamin D Related
  2. VD/VDR

VD/VDR

Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D2 (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D3 (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D2 and vitamin D3.

Topical agents containing active vitamin D3 (calcitriol, 1α, 25- dihydroxyvitaminD3, VD3) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

VD/VDR 相关产品 (53):

Cat. No. Product Name Effect Purity
  • HY-10002
    Calcitriol Agonist 99.81%
    Calcitriol 是vitamin D的活性代谢物。Calcitriol的作用受其与vitamin D receptor (VDR) 受体作用的调节。
  • HY-10001
    Calcipotriol Chemical 99.33%
    Calcipotriol 是一种合成的 VitD3 类似物,对 vitamin D 受体具有高亲和力。
  • HY-32339
    Maxacalcitol Activator
    Maxacalcitol (22-Oxacalcitriol)是维生素D3类似物。
  • HY-50919
    Paricalcitol Agonist 99.95%
    Paricalcitol 是 vitamin D receptor 的激活剂,用于治疗继发性甲状旁腺功能亢进(分泌过多的甲状旁腺激素),该疾病与慢性肾功能衰竭有关。
  • HY-32351A
    Calcifediol monohydrate 99.88%
    Calcifediol monohydrate 是维生素 D3 的主要循环代谢物, 是一种竞争性抑制剂,Ki 值为 3.9 μM。
  • HY-32349
    Ercalcidiol Modulator 99.34%
    Ercalcidiol 是一种 vitamin D2 代谢物,作为 vitamin D 营养状态的指标。
  • HY-10003
    Alfacalcidol Activator 99.76%
    Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3)是非选择性VDR活化剂。
  • HY-15254
    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 Chemical >98.0%
    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 是一种Vitamin D3 衍生物。
  • HY-32341
    Seocalcitol Agonist 98.67%
    Seocalcitol 是一种 vitamin D 类似物,作用于人骨肉瘤 MG-63 细胞,结合 vitamin D 受体蛋白,Kd 为 0.27 nM。
  • HY-15398
    Cholecalciferol Activator >98.0%
    Cholecalciferol(Vitamin D3)是维生素D的天然存在形式,代谢激活后能诱导细胞分化和癌细胞增殖。
  • HY-32343
    Secalciferol Activator 99.58%
    Secalciferol是维生素D的代谢物,是潜在的参与骨化作用的抗炎甾体。
  • HY-10001A
    Calcipotriol monohydrate Activator 99.67%
    Calcipotriol是1,25-Dihydroxyvitamin D3类似物,可作用于银屑病。
  • HY-32350
    Ercalcitriol Activator 98.50%
    Ercalcitriol (1α,25-Dihydroxy Vitamin D2)是维生素D2活性代谢物。
  • HY-75958
    Vitamin D4 Activator 99.62%
    Vitamin D4是维生素D的活性类似物。
  • HY-75041
    Calcitriol Impurities A Activator 99.51%
    Calcitriol Impurities A是Calcitriol的杂质,Calcitriol是维生素D3的活性代谢物,能激活维生素D受体。
  • HY-15157
    Calcitetrol Activator
    Calcitetrol(1α, 24, 25-Trihydroxy VD3)是含3个羟基的维生素D活性形式。
  • HY-32348
    Doxercalciferol Activator 99.50%
    Doxercalciferol (Hectorol; 1.alpha.-Hydroxyvitamin D2)是维生素D2类似物,可作为维生素D受体活化剂。
  • HY-A0020
    Eldecalcitol Activator 99.89%
    Eldecalcitol(ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3)是1,25-二羟基维生素D3的类似物。
  • HY-13292
    Impurity B of Calcitriol Activator
    Impurity B of Calcitriol是Calcitriol的杂质,Calcitriol是维生素D3的活性代谢物,能激活维生素D受体。
  • HY-76814
    Calcitriol D6 Activator 98.63%
    Calcitriol D6是骨化三醇的含重氢形式,骨化三醇是维生素D3的活性代谢物。