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  2. Myosin

Myosin

Myosin light chain kinase (MLCK) is a ubiquitous Ca2+/calmodulin (CaM)-activated kinase found in smooth, cardiac, and skeletal muscle as well as in mammalian nonmuscle cells.

Myosin light chain kinase (MLCK) is a regulatory protein forsmooth muscle contraction, which acts by phosphorylating 20-kDamyosin light chain (MLC20) to activate the myosin ATPase activity.Myosin light chain kinase (MLCK) of smooth muscle hasbeen puried as an enzyme that phosphorylates 20-kDa lightchain of smoothmuscle myosin (MLC20).

Analysis of the cross talk between Ras-ERK and PI3K-AKT signaling pathways reveals integrin β1, myosin light chain kinase (MLCK) and myosin IIA are required for the activation of PI3K-AKT following inhibition of the Ras-ERK pathway. Integrin β1, MLCK, and myosin IIA are factors in the development of resistance to MEK inhibitors.

Myosin light chain kinase (MLCK) phosphorylates the regulatory light chain (RLC) of myosin producing increases in force development during skeletal muscle contraction.

Myosin 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-13441
    (-)-Blebbistatin Inhibitor 99.47%
    (-)-Blebbistatin是 blebbistatin 的S对映异构体。 布比斯他汀是一种有效和选择性 myosin II 抑制剂,IC50值在0.5至 5 μM之间。
  • HY-14233
    Omecamtiv mecarbil Activator 99.28%
    Omecamtiv mecarbil 是具有选择性的 myosin 激活剂,常用于治疗心血管疾病。
  • HY-15417
    ML-7 hydrochloride Inhibitor 98.18%
    ML-7 hydrochloride 是一种萘磺酰胺衍生物,有效抑制 MLCK (IC50=300 nM) 和 TRPC6 通道 (IC50>10 μM)。
  • HY-16690
    BTS Inhibitor 99.57%
    BTS是钙离子刺激的肌球蛋白S1ATP酶抑制剂(IC50为 5 μM),能可逆地阻断滑行运动。
  • HY-P1029
    MLCK inhibitor peptide 18 Inhibitor 98.71%
    MLCK inhibitor peptide 18 是一种有效的 MLCK 抑制剂,IC50 值为 50 nM,同时较弱抑制 CaM kinase II 的活性。
  • HY-100984
    HA-100 Inhibitor 99.76%
    HA-100 是 cGMP 依赖性蛋白激酶 (PKG),cAMP 依赖性蛋白激酶 (PKA),蛋白激酶 C (PKC) 和 MLC 激酶 (MLC-kinase) 的抑制剂,其 IC50 值分别为 4, 8, 12 和 240 μM。