1. MAPK/ERK Pathway
  2. MAP3K

MAP3K

MAP3Ks (Mitogen-activated protein kinase kinase kinases), the top components of MAPK cascades, modulate many biological processes, such as growth, development and various environmental stresses. Based on the sequence of their kinase catalytic domain, MAP3Ks are classified into three groups: the MEKK-like, ZIK-like and Raf-like families. Raf-like MAP3Ks constitute largest MAP3K subfamily. Raf-like MAP3Ks play roles in response to biotic and abiotic stresses.

MAP3Ks often bind to both MAP4Ks and MAP2Ks in the same pathway. For example, MEKK1 (MAP3K1) binds to both the MAP4K NIK and the MAP2K MKK4, while NSY-1 (MAP3K) binds to the MAP2K SEK-1. MAP3Ks activates MAP2Ks by phosphorylation of a serine and/or threonine, and MAP2Ks activate MAPKs by dual phosphorylation of a Thr-X-Tyr motif.

MAP3K Isoform Specific Products:

  • MAP3K5/ASK1

  • MAP3K7/TAK1

MAP3K 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-103490
    Takinib Inhibitor 98.00%
    Takinib 是一种有效且有选择性的 TAK1 抑制剂,其 IC50 值为 9.5 nM。
  • HY-18938
    Selonsertib Inhibitor 98.04%
    Selonsertib 是一种有效的凋亡信号调节激酶 1 (ASK1) 抑制剂,pIC50 为 8.3±0.07。
  • HY-15434
    NG25 Inhibitor 99.45%
    NG25 是一种 TAK1MAP4K2 的双重抑制剂,IC50 值分别为 149 nM 和 21.7 nM。
  • HY-19566
    NQDI-1 Inhibitor
    NQDI-1 抑制凋亡信号调节激酶 1 (ASK1),Ki 为 500 nM,IC50 为 3 μM.
  • HY-12686
    5Z-7-Oxozeaenol Inhibitor >99.0%
    5Z-7-Oxozeaneol 是一种天然的抗原生动物化合物,为有效的,不可逆的,选择性的 TAK1VEGF-R2 抑制剂,IC50 值分别为 8 nM 和 52 nM。
  • HY-100844
    ASK1-IN-1 Inhibitor 99.33%
    ASK1-IN-1 是一种凋亡信号调节激酶 1 (ASK1) 抑制剂,详细信息参考专利 WO2016025474A1 中的化合物 4。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.