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Caspase

Caspase is a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation. There are two types of apoptotic caspases: initiator (apical) caspases and effector (executioner) caspases. Initiator caspases (e.g., CASP2, CASP8, CASP9, and CASP10) cleave inactive pro-forms of effector caspases, thereby activating them. Effector caspases (e.g., CASP3, CASP6, CASP7) in turn cleave other protein substrates within the cell, to trigger the apoptotic process. The initiation of this cascade reaction is regulated by caspase inhibitors. CASP4 and CASP5, which are overexpressed in some cases of vitiligo and associated autoimmune diseases caused by NALP1 variants, are not currently classified as initiator or effector in MeSH, because they are inflammatory enzymes that, in concert with CASP1, are involved in T-cell maturation.

Caspase (13)
产品名称 目录号 简述
ASK1-IN-1 HY-100844

ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4.

Biotin-VAD-FMK HY-100894

Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

BOC-D-FMK HY-13229

Caspase3-Inhibitor BOC-D-FMK是新型Caspase-3抑制剂。

Emricasan HY-10396

Emricasan (IDN-6556, PF-03491390) is a potent irreversible pan-caspase inhibitor.

Naringenin HY-N0100

Naringenin is the predominant flavanone in grapefruit; displays strong anti-inflammatory and antioxidant activities.

NQDI-1 HY-19566

NQDI-1 inhibits apoptosis signal-regulating kinase 1 (ASK1) with a Ki of 500 nM.

PAC-1 HY-13523

PAC-1(Procaspase-activating compound-1)是首个Caspase活化化合物,EC50值为0.22uM,能增强procaspase-3活性并诱导多种癌细胞和小鼠肿瘤模型凋亡。

Q-VD-OPh HY-12305

Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 1, 3, 8 and 9 with IC50 values of 50, 25, 100, and 430 nM, respectively.

Selonsertib HY-18938

GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.

Taurochenodeoxycholic acid HY-N2027

Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.

VX-765 HY-13205

VX-765(Belnacasan)是caspase-1选择性抑制剂,Ki为0.8 nM。

Z-DEVD-FMK HY-12466

Z-DEVD-FMK是Caspase-3的特异不可逆抑制剂,对Caspase-6、-7、-8和Caspase-10也有抑制作用。

Z-VAD-FMK HY-16658

Z-VAD-FMK是可渗透细胞的不可逆广谱caspase抑制剂,能阻断凋亡。

Tags: Caspase 抑制 | Caspase 蛋白 | Caspase 抑制剂 | Caspase FDA上市药物 | Caspase 和癌症 | Caspase 活性 | Caspase 激活 | Caspase 信号通路 | Caspase 抑制剂筛选 | Caspase 高通量筛选 | Caspase 抑制剂临床 | Caspase 抑制剂药物 | Caspase 抑制剂综述 | Caspase 抑制剂研发 | Caspase 抑制剂供应商 | Caspase 抑制剂分销商

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