1. Apoptosis
  2. Caspase


Caspase is a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation. There are two types of apoptotic caspases: initiator (apical) caspases and effector (executioner) caspases. Initiator caspases (e.g., CASP2, CASP8, CASP9, and CASP10) cleave inactive pro-forms of effector caspases, thereby activating them. Effector caspases (e.g., CASP3, CASP6, CASP7) in turn cleave other protein substrates within the cell, to trigger the apoptotic process. The initiation of this cascade reaction is regulated by caspase inhibitors. CASP4 and CASP5, which are overexpressed in some cases of vitiligo and associated autoimmune diseases caused by NALP1 variants, are not currently classified as initiator or effector in MeSH, because they are inflammatory enzymes that, in concert with CASP1, are involved in T-cell maturation.

Caspase 相关产品 (19):

Cat. No. Product Name Effect Purity
  • HY-16658
    Z-VAD(OMe)-FMK Inhibitor >98.0%
    Z-VAD(OMe)-FMK 是一种可渗透细胞的 pan-caspase 抑制剂。
  • HY-10396
    Emricasan Inhibitor 99.73%
    Emricasan 是一种不可逆的 pan-caspase 抑制剂。
  • HY-13251
    Silvestrol Activator 99.28%
    Silvestrol 是一种天然产物,能够激活 caspase-3 来诱导细胞凋亡。
  • HY-13205
    VX-765 Inhibitor 99.46%
    VX-765 是一种口服活性的 IL-转化酶/caspase-1 抑制剂,抑制 IL-1β 释放。
  • HY-12466
    Z-DEVD-FMK Inhibitor >98.0%
    Z-DEVD-FMK 是一种特异性的 caspase-3 抑制剂,IC50 为 18 μM。
  • HY-P1001
    Ac-DEVD-CHO Inhibitor 98.84%
    Ac-DEVD-CHO 是一种特异性 Caspase-3 抑制剂,Ki 值为 230 pM.
  • HY-10397
    EP1013 Inhibitor
    EP1013 是一种广谱的 caspase 选择性抑制剂,可用于 1 型糖尿病研究。
  • HY-103667
    2-HBA Activator 98.83%
    2-HBA 是一个有效的 NAD(P)H: 醌受体氧化还原酶 1 (NQO1) 诱导剂,也可以激活半胱天冬酶-3 (caspase-3) 和半胱天冬酶-10 (caspase-10)。
  • HY-18938
    Selonsertib Inhibitor 98.04%
  • HY-12305
    Q-VD-OPh Inhibitor 99.26%
    Q-VD-OPha是泛胱天蛋白酶(caspase)抑制剂,具有高效的抗凋亡能力。抑制胱天蛋白酶1, 3, 8, 9的IC50值分别为50, 25, 100, and 430 nM。
  • HY-13010
    Laquinimod Inhibitor 99.96%
    Laquinimod 是一种有效的免疫调节剂。
  • HY-101297
    Z-IETD-FMK Inhibitor >98.0%
    Z-IETD-FMK是选择性和细胞可渗透的胱天蛋白酶 (caspase 8) 抑制剂。
  • HY-13523
    PAC-1 Activator
    PAC-1 是一种 procaspase-3 激活剂,诱导癌细胞凋亡,EC50 为 2.08 μM。
  • HY-13229
    BOC-D-FMK Inhibitor
    Boc-D-FMK是可渗透细胞,不可逆的,泛半胱天冬酶抑制剂。抑制TNF-α诱导的细胞凋亡的IC50值为39 µM。
  • HY-19566
    NQDI-1 Inhibitor 98.04%
    NQDI-1抑制凋亡信号调节激酶1 (ASK1), Ki值为500 nM.
  • HY-N2027
    Taurochenodeoxycholic acid Activator 99.80%
    Taurochenodeoxycholic acid是动物胆汁酸的主要生物活性物质之一。
  • HY-N0100
    Naringenin 98.05%
    Naringenin是葡萄柚中主要的黄烷酮; 显示出强烈的抗炎和抗氧化活性。
  • HY-100844
    ASK1-IN-1 Inhibitor 99.33%
    ASK1-IN-1 是一种凋亡信号调节激酶 1 (ASK1) 抑制剂,详细信息参考专利 WO2016025474A1 中的化合物 4。
  • HY-100894
    Biotin-VAD-FMK Inhibitor >98.0%