首页 产品 化合物库 服务 Kit 关于我们 联系我们

信号通路

在线客服 在线询单 如何订购 促销产品 销售网络 定制服务

在线询价

温馨提示:客服在线时为9:00-18:00,
其他时间可发邮件至sales@medchemexpress.cn,我们会尽快回复您。

Deubiquitinase

Deubiquitinases (DUBs) are a large group of proteases that cleave ubiquitin from proteins and other molecules. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate thecellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions. DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are nearly 100 DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases. The cysteine proteases comprise ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), Machado-Josephin domain proteases (MJDs) and ovarian tumour proteases (OTU). The metalloprotease group contains only the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases. DUBs play several roles in the ubiquitin pathway. One of the best characterised functions of DUBs is the removal of monoubiqutin and polyubiquitin chainsfrom proteins.

Deubiquitinase (19)
产品名称 目录号 简述
b-AP15 HY-13989

b-AP15(NSC687852)是去泛素化酶UCHL5和Usp14抑制剂,能阻断26S蛋白酶体的去泛素化活性。

BAY 11-7082 HY-13453

BAY 11-7082 is an irreversible inhibitor of IKKα and phosphorylation of cytokine-inducible IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-α, NFKBIA; IC50=10 μM).

DUBs-IN-1 HY-50736

DUBs-IN-1是去泛素化酶抑制剂,对USP7/USP8的IC50分别为18 uM/0.71 uM。

DUBs-IN-2 HY-50737A

DUBs-IN-2是一种高效的选择性去泛素化酶USP8抑制剂,IC50为0.28 _mu_M。

DUBs-IN-3 HY-50737

DUBs-IN-3是去泛素化酶抑制剂,对USP8的IC50为3.1 uM,而对USP7的IC50则大于100 uM。

HBX 19818 HY-17540

HBX 19818是USP7抑制剂,IC50为28.1 uM。

LDN-57444 HY-18637

LDN-57444是Uch-L1高效可逆性抑制剂,Ki值为0.4uM。

ML-323 HY-17543

ML323是可逆的USP1-UAF1抑制剂,在Ub-Rho测试中IC50为76 nM。

ML364 HY-100900

ML364 is an USP2 inhibitor extracted from patent WO 2016134026 A1, compound example 10G.

NSC632839 HY-100708

NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45±4 μM, 37±1 μM, and 9.8±1.8 μM, respectively.

P 22077 HY-13865

P22077是泛素特异性蛋白酶(USP)7抑制剂,EC50为8.6 uM,还能抑制USP47。

P005091 HY-15667

P005091(P5091)是选择性泛素特异性蛋白酶7(USP7)抑制剂,EC50为4.2_mu_M。

PR-619 HY-13814

PR-619是广谱的DUB抑制剂,对于USP4、USP2和USP20的EC50分别为3.93 _mu_M、7.2 _mu_M和5.10 _mu_M。

SJB2-043 HY-15757

SJB2-043是C527的类似物,是新型的泛素特异蛋白酶USP1抑制剂,IC50为544nM。

SJB3-019A HY-80012

SJB3-019A是新型的USP1抑制剂,在促进ID1降解和K562细胞毒性方面5倍强于SJB2-043,IC50为78nM。

USP7-IN-1 HY-16709

USP7-IN-1是新型USP7选择可逆性小分子抑制剂,IC50值为33uM,对USP5、USP8、Uch-L1、Uch-L和Caspase的抑制剂弱或无(IC50>200uM),对HCT116细胞GI50值为67uM。

USP7-USP47 inhibitor HY-13487

USP7/USP47 inhibitor是USP7/USP47的抑制剂,IC50分别为0.42 uM和1.0 uM。

VLX1570 HY-12471

VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM.

WP1130 HY-13264

WP1130(Degrasyn)是去泛素化酶(USP5,UCH-L1,USP9x,USP14和UCH37)抑制剂及Bcr/Abl破坏通路激活剂,在K562细胞中的IC50 为1.8 _mu_M。

Tags: Deubiquitinase 抑制 | Deubiquitinase 蛋白 | Deubiquitinase 抑制剂 | Deubiquitinase FDA上市药物 | Deubiquitinase 和癌症 | Deubiquitinase 活性 | Deubiquitinase 激活 | Deubiquitinase 信号通路 | Deubiquitinase 抑制剂筛选 | Deubiquitinase 高通量筛选 | Deubiquitinase 抑制剂临床 | Deubiquitinase 抑制剂药物 | Deubiquitinase 抑制剂综述 | Deubiquitinase 抑制剂研发 | Deubiquitinase 抑制剂供应商 | Deubiquitinase 抑制剂分销商

SiteMap

MCE所有的产品和服务只应用于科学研究,我们不提供产品和服务给任何个人。

Copyright © 2013-2014 MedChemexpress All Rights Reserved 沪ICP备15051369号-1