1. Cell Cycle/DNA Damage
  2. Deubiquitinase


Deubiquitinases (DUBs) are a large group of proteases that cleave ubiquitin from proteins and other molecules. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate thecellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions. DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are nearly 100 DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases. The cysteine proteases comprise ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), Machado-Josephin domain proteases (MJDs) and ovarian tumour proteases (OTU). The metalloprotease group contains only the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases. DUBs play several roles in the ubiquitin pathway. One of the best characterised functions of DUBs is the removal of monoubiqutin and polyubiquitin chainsfrom proteins.

Deubiquitinase 相关产品 (20):

Cat. No. Product Name Effect Purity
  • HY-13453
    BAY 11-7082 Inhibitor 99.64%
    BAY 11-7082 是一种 NF-κB 抑制剂,抑制泛素特异性蛋白酶 (USP)7 和 21,IC50 分别为 0.19 μM 和 0.96 μM。
  • HY-12471
    VLX1570 Inhibitor 98.00%
    VLX1570是一个竞争性的DUBs的抑制剂,IC50的范围在4.2 uM到8.6 uM,对USP14有很强的抑制作用。
  • HY-50737A
    DUBs-IN-2 Inhibitor 99.08%
    DUBs-IN-2 是一种有效的 deubiquitinase 抑制剂,能够抑制 USP7/USP8 的活性,IC50 值分别为 7.2 μM/0.93 μM。
  • HY-13264
    WP1130 Inhibitor 99.72%
    WP1130 通过快速下调 Bcr-Abl,而抑制 Bcr-Abl 自身活化,IC50 为 1.8 μM。WP1130 也是一种去泛素化酶 (deubiquitinase) 抑制剂。
  • HY-15667
    P005091 Inhibitor 98.26%
    P005091 是一种有效的,选择性的泛素特异性蛋白酶7 (USP7) 抑制剂,EC50 值为 4.2 μM。
  • HY-13817
    IU1 Inhibitor >98.0%
    IU1 是一种特异性的 Usp14,IC50 为 4-5 μM.
  • HY-13865
    P 22077 Inhibitor 98.50%
    P22077是泛素特异性蛋白酶(USP)7抑制剂,EC50为8.6 uM,还能抑制USP47。
  • HY-17540
    HBX 19818 Inhibitor
    HBX 19818是USP7抑制剂,IC50为28.1 uM。
  • HY-13989
    b-AP15 Inhibitor 98.03%
    b-AP15 特异性抑制去泛素化酶 (deubiquitinating) UCHL5Usp14活性。
  • HY-17543
    ML-323 Inhibitor 99.61%
    ML-323 是一种有效的可逆的 USP1-UAF1 抑制剂,在Ub-Rho实验中,IC50 为 76 nM。
  • HY-80012
    SJB3-019A Inhibitor >99.00%
    SJB3-019A 是一种新颖的,有效的 USP1 抑制剂,在 K562 细胞中,IC50 值为 0.0781 μM。
  • HY-13814
    PR-619 Inhibitor 98.07%
    PR-619 是一种 DUB 抑制剂,作用于 USP4USP8USP7USP2USP5EC50 分别为 3.93,4.9,6.86,7.2 和 8.61 μM。
  • HY-13487
    USP7/USP47 inhibitor Inhibitor 98.17%
    USP7/USP47 inhibitor是USP7/USP47的抑制剂,IC50分别为0.42 uM和1.0 uM。
  • HY-100900
    ML364 Inhibitor 99.81%
    ML364是USP2的抑制剂,来自专利WO 2016134026 A1化合物实例10G。
  • HY-50737
    DUBs-IN-3 Inhibitor 99.40%
    DUBs-IN-3来自引用文献化合物22c,是去泛素化酶 (deubiquitinase (USP)) 抑制剂,对USP8的 IC50 值为0.56 μM
  • HY-18637
    LDN-57444 Inhibitor 98.65%
  • HY-15757
    SJB2-043 Inhibitor 99.30%
    SJB2-043 抑制 USP1/UAF1 复合体,IC50 为 544 nM。
  • HY-100708
    NSC632839 Inhibitor 98.37%
    NSC632839 是一种非选择性肽酶抑制剂,抑制 USP2USP7SENP2EC50 分别为 45±4 μM,37±1 μM 和 9.8±1.8 μM。
  • HY-16709
    USP7-IN-1 Inhibitor 99.77%
  • HY-50736
    DUBs-IN-1 Inhibitor 99.46%
    DUBs-IN-1是去泛素化酶抑制剂,对USP7/USP8的IC50分别为18 uM/0.71 uM。