1. Cell Cycle/DNA Damage
  2. CDK

CDK

CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase.

There are around 20 Cyclin-dependent kinases (CDK1-20) known till date. CDK1, 4 and 5 are involved in cell cycle, and CDK 7, 8, 9 and 11 are associated with transcription.

CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of S. pombe (Cdc2), S. cerevisia (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).

CDK Isoform Specific Products:

  • CDK1

  • CDK2

  • CDK3

  • CDK4

  • CDK5

  • CDK6

  • CDK7

  • CDK8

  • CDK9

  • CDK12

  • CDK13

  • CDK19

  • CDC

  • CLK

  • CDK16

  • CDK14

CDK 相关产品 (106):

Cat. No. Product Name Effect Purity
  • HY-50767
    Palbociclib Inhibitor 99.94%
    Palbociclib (PD 0332991) 是选择性的 CDK4CDK6 抑制剂,IC50 分别为11 nM,16 nM。 Palbociclib是一种治疗ER阳性和HER2阴性乳腺癌的药物。
  • HY-16297
    Abemaciclib methanesulfonate Inhibitor 99.95%
    Abemaciclib (LY2835219) (methanesulfonate) 是选择性的 CDK4/6 抑制剂,抑制 CDK4/CDK6 的 IC50 分别为 2 nM 和 10 nM。
  • HY-50767A
    Palbociclib hydrochloride Inhibitor 99.94%
    Palbociclib hydrochloride是高选择性的 CDK4/6 抑制剂,IC50 分别为11 nM 和 16 nM。
  • HY-15777
    Ribociclib Inhibitor 99.85%
    Ribociclib (LEE011) 是高选择性的 CDK4/6 抑制剂,IC50 分别为10 nM,39 nM。
  • HY-10492
    Dinaciclib Inhibitor 99.10%
    Dinaciclib 是一种有效的选择性 CDK 抑制剂,抑制 CDK2CDK5CDK1CDK9IC50 分别为 1,1,3 和 4 nM。
  • HY-114177
    PF-06873600 Inhibitor 99.98%
    PF-06873600 是具有口服活性的、细胞周期蛋白依赖性激酶 (CDK) 的选择性抑制剂,其对 CDK2、CDK4 和 CDK6 的 Ki 值分别为 0.09 nM、0.13 nM 和 0.16 nM. PF-06873600 具有潜在的抗肿瘤活性[1][2]
  • HY-119940
    (rel)-MC180295 Inhibitor
    (rel)-MC180295 是一种有效、选择性的 CDK9-Cyclin T1 抑制剂,IC50 值为 5 nM,对其选择性至少是对其他 CDK 激酶 22 倍,包括 CDK1-Cyclin B (IC50,138 nM),CDK2-Cyclin A (IC50,233 nM),CDK2-Cyclin E (IC50,367 nM),CDK3-Cyclin E (IC50,399 nM),CDK4-Cyclin D (IC50,112 nM),CDK5-P35 (IC50,159 nM),CDK5-P25 (IC50,186 nM),CDK6-Cyclin D3 (IC50,712 nM) 和 CDK7-CycH/MAT1 (IC50,555 nM)。(rel)-MC180295 同时抑制 GSK-3α 和 GSK-3β。(rel)-MC180295 具有的抗肿瘤活性[1]
  • HY-112272A
    Lerociclib dihydrochloride Inhibitor 98.45%
    Lerociclib (G1 T38) dihydrochloride 是一种有效的选择性 CDK4/CDK6 抑制剂,抑制 CDK4/CyclinD1CDK6/CyclinD3IC50 值分别为 1 nM 和 2 nM。
  • HY-80013
    THZ1 Inhibitor 98.82%
    THZ1 是有效,选择性的共价 CDK7 抑制剂,IC50 为 3.2 nM。
  • HY-30237
    Seliciclib Inhibitor 99.94%
    Roscovitine是有效,选择性的 CDKs 抑制剂,抑制 CDK5CDK2CDK2IC50 分别为0.2 μM,0.65 μM,0.7 μM。
  • HY-103618
    THZ531 Inhibitor 99.86%
    THZ531 是 CDK12CDK13 的共价抑制剂,其 IC50 值分别为 158 nM 和 69 nM。
  • HY-A0065
    Palbociclib isethionate Inhibitor 99.99%
    Palbociclib isethionate是高选择性的 CDK4/6 抑制剂,IC50 为11 nM/16 nM。
  • HY-12529
    Ro-3306 Inhibitor
    Ro-3306 是一种有效,选择性的 CDK1 抑制剂,对 CDK1,CDK1/cyclin B1 和 CDK2/cyclin E 的 Ki 值为分别为 20 nM,35 nM 和 340 nM。
  • HY-10005
    Flavopiridol Inhibitor 99.70%
    Flavopiridol 是一种竞争型的 CDK 广谱抑制剂, 抑制 CDK1,CDK2,CDK4的IC50 分别为30,170,100 nM。
  • HY-80013A
    THZ1 Hydrochloride Inhibitor 98.70%
    THZ1 Hydrochloride 是一种有效,选择性的 CDK7 抑制剂,IC50 值为 3.2 nM。
  • HY-12214A
    NVP-2 Inhibitor 99.29%
    NVP-2 是一种 CDK9 抑制剂,其 IC50 值为 0.5 nM。
  • HY-12871
    Atuveciclib Racemate Inhibitor 98.48%
    BAY-1143572 Racemate是BAY-1143572的外消旋混合物。 BAY-1143572是一种有效且高选择性的口服 P-TEFb/CDK9 抑制剂,CDK9/CycT1IC50 为13 nM。
  • HY-101212
    CYC065 Inhibitor 98.58%
    CYC065 是第二代口服有效的 ATP 竞争性的 CDK2 / CDK9 激酶抑制剂。
  • HY-10012
    AZD-5438 Inhibitor 99.84%
    AZD-5438 是一种有效的 CDK1/2/9 抑制剂,IC50 值分别为 16 nM/6 nM/20 nM;同时抑制 GSK3β,对 CDK5/6 的作用较弱。
  • HY-12302
    Kenpaullone Inhibitor 98.07%
    Kenpaullone 是一种有效的 CDK1/cyclin BGSK-3β 抑制剂,IC50 值分别为 0.4 μM 和 23 nM,同时可抑制 CDK2/cyclin A,CDK2/cyclin E 和 CDK5/p25 的活性,IC50 值分别为 0.68 μM,7.5 μM 和 0.85 μM。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.