1. Cell Cycle/DNA Damage
  2. CDK

CDK

CDKs (Cyclin-dependent kinases) are a family of protein kinases first discovered for their role in regulating the cell cycle. Types: Cdk1, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8, Cdk9, Cdk11. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. They are present in all knowneukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase. CDKs phosphorylate their substrates on serines and threonines, so they are serine-threonine kinases. CDK levels remains relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of S. pombe (Cdc2), S. cerevisiae (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).

CDK 相关产品 (76):

Cat. No. Product Name Effect Purity
  • HY-16297
    LY2835219 Inhibitor 99.87%
    LY2835219 是具有选择性的 CDK4/6 抑制剂,能够抑制 CDK4/CDK6 的活性,IC50 分别为 2 nM 和 10 nM。
  • HY-50767
    Palbociclib Inhibitor 99.99%
    Palbociclib 是一种高特异性的 Cdk4Cdk6 抑制剂,IC50 分别为 11 nM 和 16 nM。
  • HY-80013
    THZ1 Inhibitor 98.82%
    THZ1 是一种有效的选择性的共价 CDK7 抑制剂,IC50 为 3.2 nM。
  • HY-80013A
    THZ1 Hydrochloride Inhibitor 98.70%
    THZ1 Hydrochloride 是一种有效的 CDK7 抑制剂,IC50 值为 3.2 nM。
  • HY-50767A
    Palbociclib hydrochloride Inhibitor 99.94%
    Palbociclib hydrochloride 是一种高度特异性的 Cdk4Cdk6 抑制剂,IC50 值分别为 11 nM 和 16 nM。
  • HY-19984
    CCT-251921 Inhibitor 98.70%
    CCT-251921是有效,选择性,有口服活性的CDK8抑制剂;IC50值为2.3 nM。
  • HY-101611
    MSC2530818 Inhibitor 99.59%
    MSC2530818是有效,选择性,有口服活性的 CDK8/19 抑制剂,抑制 CDK8 的IC50值为2.6 nM。
  • HY-12653
    LDC4297 Inhibitor 99.14%
    LDC4297是高效和选择性的CDK7抑制剂,IC50值为0.13 nM。
  • HY-10492
    Dinaciclib Inhibitor 99.10%
    Dinaciclib 是一种有效的选择性 CDK 抑制剂,抑制 CDK2CDK5CDK1CDK9 活性,IC50 分别为 1,1,3 和 4 nM。
  • HY-A0065
    Palbociclib isethionate Inhibitor 99.99%
    Palbociclib isethionate 是高度选择性的 CDK4/6 抑制剂,IC50 值分别为 11 nM/16 nM;对 CDK1/2/5,EGF,FGFR,PDGFR,InsR 等没有作用。
  • HY-15777
    LEE011 Inhibitor 99.82%
    LEE011 是一种高特异性的 CDK4/6 抑制剂,IC50 分别为 10 nM 和 39 nM。
  • HY-30237
    Roscovitine Inhibitor 99.77%
    Roscovitine 是一种有效的选择性 CDK 抑制剂,抑制 CDK5Cdc2CDK2IC50 分别为 0.2 μM,0.65 μM 和 0.7 μM。
  • HY-12529
    Ro-3306 Inhibitor 98.20%
    Ro-3306是CDK1高效选择性抑制剂,对CDK1/cyclin B1的Ki值为35nM。
  • HY-10005
    Flavopiridol Inhibitor 99.11%
    Flavopiridol 是一种 CDK 的广谱抑制剂,与 ATP 竞争性地抑制 CDK1,CDK2,CDK4 和 CDK6 的活性,IC50 值约为 40 nM。
  • HY-12280
    THZ2 Inhibitor 99.74%
    THZ2 是一种有效的,选择性的 CDK7 抑制剂,IC50 值为 13.9 nM。
  • HY-13942
    1-NM-PP1 Inhibitor 98.83%
    1-NM-PP1 抑制突变型 Cdk7,IC50 约为 50 nM。
  • HY-10580
    BIO Inhibitor 98.37%
    BIO 是一种有效的,选择性的 GSK-3CDK1-cyclinB 复合体抑制剂,能够抑制 GSK-3αβ/CDK1/CDK5 的活性,IC50 值分别为 5 nM/320 nM/83 nM。
  • HY-10012
    AZD-5438 Inhibitor 99.84%
    AZD-5438 是一种有效的 CDK1/2/9 抑制剂,IC50 值分别为 16 nM/6 nM/20 nM;同时抑制 GSK3β,对 CDK5/6 的作用较弱。
  • HY-19988
    THZ1-R Inhibitor 98.30%
    THZ1-R是非半胱氨酸反应性类似物,对CDK7活性较低, 且降低抗增殖效力。
  • HY-13266
    BS-181 Inhibitor 99.72%
    BS-181 是一种高度选择性的 CDK7 抑制剂,IC50 值为 21 nM,对 CDK7 的选择性是对 CDK1,2,4,5,6 和 9 的 40 多倍。