1. Stem Cell/Wnt
  2. Notch


Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as Notch1, Notch2, Notch3, and Notch4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. The notch signaling pathway is important for cell-cell communication, which involves gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life.

Notch 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-11102
    RO4929097 Inhibitor 98.02%
    RO4929097 是一种 γ secretase 抑制剂,IC50 值为 4 nM,能够抑制细胞内 Aβ40 的产生和 Notch 活性,EC50 值分别为 14 nM 和 5 nM。
  • HY-50752
    LY-411575 Inhibitor 99.22%
    LY-411575 是高效的 γ-secretase 抑制剂,能够抑制 Aβ40 蛋白的产生,其 IC50 值为 0.078 nM/0.082 nM(基于膜/细胞),同时抑制 Notch 分裂,IC50 值为 0.39 nM。
  • HY-50845
    BMS-708163 Inhibitor 99.95%
    BMS-708163 是有效的 γ-secretase 抑制剂,抑制 Aβ42 和 Aβ40 的产生,IC50 值分别为 0.27 nM 和 0.30 nM;同时抑制 Notch 胞内结构域 (NICD) 和 CYP2C19,IC50 值分别为 0.84 nM 和 20 μM。
  • HY-10009
    Semagacestat Inhibitor 98.90%
    Semagacestat 是一种 γ-secretase 抑制剂,抑制 β-amyloid (Aβ42),Aβ38Aβ40IC50 分别为 10.9,12 和 12.1 nM。也抑制 NotchIC50 为 14.1 nM。
  • HY-12449
    LY3039478 Inhibitor 98.01%
  • HY-13526
    YO-01027 Inhibitor 98.22%
    YO-01027 (Dibenzazepine;DBZ)是高效的γ-分泌酶抑制剂,裂解NotchAPPLIC50分别为2.92±0.22和 2.64±0.30 nM。
  • HY-100431
    IMR-1 Inhibitor 99.13%
    IMR-1是一个新的Notch抑制剂,针对转录激活,IC50是6 μmol/L.
  • HY-N0133
    Tangeretin Inhibitor 98.98%
  • HY-12419
    BMS-983970 Inhibitor 99.04%
  • HY-15860
    FLI-06 Inhibitor 98.06%
    FLI-06是Notch信号传导的抑制剂,EC50值为2.3 μM。
  • HY-100431A
    IMR-1A Inhibitor 98.06%
    IMR-1A是IMR-1的代谢物,IMR-1是一个新的靶点在转录活性上的Notch抑制剂,IC50是 6umol/L.
  • HY-12465
    Z-Ile-Leu-aldehyde Inhibitor
    Z-Ile-Leu-aldehyde(Z-IL-CHO; GSI-XII)是_gamma_-secretase抑制剂,Notch信号转导抑制剂。
  • HY-N0232
    Psoralidin Inhibitor