1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

STAT

STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The transcription factors of this family are activated by Janus kinase and dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance. STAT proteins were originally described as latent cytoplasmic transcription factors that require phosphorylation for nuclear retention. The unphosphorylated STAT proteins shuttle between cytosol and the nucleus waiting for its activation signal. Once the activated transcription factor reaches the nucleus, it binds to consensus DNA-recognition motif called gamma-activated sites (GAS) in the promoter region of cytokine-inducible genes and activates transcription of these genes.

STAT 相关产品 (36):

Cat. No. Product Name Effect Purity
  • HY-12000
    AG-490 Inhibitor 99.84%
    AG-490 是一种酪氨酸激酶抑制剂,抑制 EGFRStat-3
  • HY-13818
    Stattic Inhibitor >98.0%
    Stattic 是一种有效的 STAT3 抑制剂,常用于癌症治疗。
  • HY-15146
    NSC 74859 Inhibitor 98.90%
    NSC 74859 是一种 Stat3 抑制剂,选择性抑制 Stat3 DNA- 结合活性,IC50 为 86±33 μM。
  • HY-100614
    AS1517499 Inhibitor 99.17%
    AS1517499 是一种有效的 STAT6 抑制剂,IC50 为 21 nM。
  • HY-N0174
    Cryptotanshinone Inhibitor 98.51%
    Cryptotanshinone 是一种有效的 STAT3 抑制剂,IC50 值为 4.6 μM,在前列腺癌细胞 DU145 中,抑制 STAT3 Tyr705 磷酸化作用。
  • HY-12987
    Pimozide Inhibitor 98.01%
    Pimozide 是 dopamine receptor 的拮抗剂,对 dopamine D2,D3 和 D1 受体的 Ki 值分别为 1.4 nM,2.5 nM 和 588 nM,同时对 α1-adrenoceptor 也有较高亲和性,Ki 值为 39 nM;Pimozide 也是 STAT3STAT5 的抑制剂。
  • HY-N0250
    Saikosaponin D Inhibitor >98.0%
    Saikosaponin D 是从柴胡中分离到的三萜皂苷类,具有抗炎,抗菌,抗肿瘤,抗过敏的功效;Saikosaponin D 可以抑制 selectinSTAT3NF-kB 的活性,活化 estrogen receptor-β
  • HY-P1061A
    Colivelin TFA Activator
    Colivelin (TFA) 是具有神经保护功能的多肽,也是 STAT3 的活化物。
  • HY-13919
    Napabucasin Inhibitor >98.0%
    Napabucasin 抑制 STAT3 基因转录,抑制癌细胞干性特征,且诱导细胞凋亡。
  • HY-15312
    WP1066 Inhibitor 99.67%
    WP1066 是一种新颖的 JAK2STAT3 抑制剂,对 STAT5 和 ERK1/2 也起作用,但对 JAK1 和 JAK3 没有影响。
  • HY-14944
    Homoharringtonine Inhibitor 98.71%
    Homoharringtonine 是一种细胞毒性生物碱,作用于 Gefitinib 耐受的肺癌细胞,诱导细胞凋亡,且通过 IL-6/JAK1/STAT3 信号通路来抑制 STAT3
  • HY-101853
    STAT5-IN-1 Inhibitor >98.0%
    STAT5-IN-1是STAT5的抑制剂,对STAT5β亚型的IC50值为47 μM。
  • HY-B0497
    Niclosamide Inhibitor
    Niclosamide 是一种 STAT 抑制剂,IC50 值为 0.7 μM,可以抑制DNA复制。
  • HY-16975
    SH-4-54 Inhibitor >98.0%
    SH-4-54是一种有效的,未磷酸化的STAT3抑制剂, 结合STAT3蛋白(KD=300 nM)。
  • HY-100493
    BP-1-102 Inhibitor 99.23%
    BP-1-102是有口服活性的转录因子Stat3的小分子抑制剂。
  • HY-100453
    HO-3867 Inhibitor 99.38%
    HO-3867是一个选择性强的STAT3抑制剂,能够在不影响STATs.抑制STAT3的磷酸化,转录,DNA绑定。
  • HY-N0751
    Scutellarin Inhibitor >98.0%
    Scutellarin 是从黄芩中分离到的黄酮类物质,在 HCC 细胞中,能够下调 STAT3/Girdin/Akt 信号通路,在破骨细胞中,能够抑制 RANKL 介导的 MAPK/NF-κB 信号通路。
  • HY-N2312
    Mogrol Inhibitor 98.06%
    Mogrol 是罗汉果甜甙的生物代谢物,能够抑制 ERK1/2STAT3 的信号通路,同时能降低 CREB 的活性,活化 AMPK
  • HY-N0156
    Oleanolic Acid Inhibitor >98.0%
    齐墩果酸(Oleanolic Acid)是一具有抗癌活性的天然化合物。
  • HY-N0193
    Artesunate Inhibitor >98.0%
    Artesunate 是 STAT-3 和输出蛋白 1 (EXP1) 的抑制剂。
Isoform Specific Products

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