1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT


STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The transcription factors of this family are activated by Janus kinase and dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance. STAT proteins were originally described as latent cytoplasmic transcription factors that require phosphorylation for nuclear retention. The unphosphorylated STAT proteins shuttle between cytosol and the nucleus waiting for its activation signal. Once the activated transcription factor reaches the nucleus, it binds to consensus DNA-recognition motif called gamma-activated sites (GAS) in the promoter region of cytokine-inducible genes and activates transcription of these genes.

STAT 相关产品 (31):

Cat. No. Product Name Effect Purity
  • HY-12000
    AG-490 Inhibitor 98.86%
    AG-490 是一种酪氨酸激酶抑制剂,抑制 EGFRStat-3
  • HY-13818
    Stattic Inhibitor >98.0%
    Stattic 是一种有效的 STAT3 抑制剂,常用于癌症治疗。
  • HY-15146
    NSC 74859 Inhibitor 98.90%
    NSC 74859 是一种 Stat3 抑制剂,选择性抑制 Stat3 DNA- 结合活性,IC50 为 86±33 μM。
  • HY-13919
    Napabucasin Inhibitor >98.0%
    Napabucasin 抑制 STAT3 基因转录,抑制癌细胞干性特征,且诱导细胞凋亡。
  • HY-N0174
    Cryptotanshinone Inhibitor 98.51%
    Cryptotanshinone 是一种有效的 STAT3 抑制剂,IC50 值为 4.6 μM,在前列腺癌细胞 DU145 中,抑制 STAT3 Tyr705 磷酸化作用。
  • HY-100602
    HJC0152 hydrochloride Inhibitor 98.86%
    HJC0152 hydrochloride 是信号转导和转录激活因子 3 (STAT3) 的抑制剂。
  • HY-103128
    inS3-54A18 Inhibitor >98.0%
    inS3-54A18 是有一种有效的 STAT3 抑制剂,具有抗癌作用。
  • HY-N0193
    Artesunate Inhibitor >98.0%
    Artesunate 是 STAT-3 和输出蛋白 1 (EXP1) 的抑制剂。
  • HY-100614
    AS1517499 Inhibitor 99.17%
    AS1517499 是一种有效的 STAT6 抑制剂,IC50 为 21 nM。
  • HY-15312
    WP1066 Inhibitor 99.67%
    WP1066 是一种新颖的 JAK2STAT3 抑制剂,对 STAT5 和 ERK1/2 也起作用,但对 JAK1 和 JAK3 没有影响。
  • HY-14944
    Homoharringtonine Inhibitor 98.71%
    Homoharringtonine 是一种细胞毒性生物碱,作用于抗 Gefitinib 的肺癌细胞,诱导细胞凋亡,且通过 IL-6/JAK1/STAT3 信号通路来抑制 STAT3
  • HY-B0497
    Niclosamide Inhibitor
    Niclosamide 是一种 STAT 抑制剂,IC50 值为 0.7 μM,可以抑制DNA复制。
  • HY-16975
    SH-4-54 Inhibitor >98.0%
    SH-4-54是一种有效的,未磷酸化的STAT3抑制剂, 结合STAT3蛋白(KD=300 nM)。
  • HY-100453
    HO-3867 Inhibitor 99.38%
  • HY-101853
    STAT5-IN-1 Inhibitor >98.0%
    STAT5-IN-1是STAT5的抑制剂,对STAT5β亚型的IC50值为47 μM。
  • HY-N2312
    Mogrol Inhibitor 98.06%
    Mogrol 是罗汉果甜甙的生物代谢物,能够抑制 ERK1/2STAT3 的信号通路,同时能降低 CREB 的活性,活化 AMPK
  • HY-100493
    BP-1-102 Inhibitor 99.23%
  • HY-N0156
    Oleanolic Acid Inhibitor >98.0%
    齐墩果酸(Oleanolic Acid)是一具有抗癌活性的天然化合物。
  • HY-N0038
    Alantolactone Activator 99.69%
  • HY-N0897
    Corylifol A Inhibitor 99.75%
    Corylifol A是从补骨脂中分离出的酚类化合物,能抑制IL-6诱导的STAT3的活化和磷酸化,还有其他生化抑制活性的报道。