1. PI3K/Akt/mTOR
  2. MELK

MELK

MELK (Maternal embryonic leucine zipper kinase) belongs to the CAMK serine/threonine protein kinase superfamily. Melk is a protein serine/threonine kinase that is maximally active during mitosis. It is involved in diverse functions such as cell cycle, cytokinesis, mRNA splicing and apoptosis. Expression MELK is expressed in cells of various tissue origins. MELK expression is strongly dependant on cell-cycle: MELK is undetectable in cells which have exited cell cycle. The exact function of MELK is currently unknown, however MELK was shown to be involved in cell cycle progression via the protein phosphatase CDC25B phosphorylation, in cytokinesis, in apoptosis via its interaction with the Bcl-2 family of proapoptotic genes and apoptosis signal-regulating kinase (ASK1) and in inhibition of mRNA splicing during mitosis via its association with NIPP1. MELK function is required for mammary tumorigenesis in vivo.

MELK 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-15512A
    OTSSP167 hydrochloride Inhibitor 99.80%
    OTSSP167 hydrochloride 是一种高效的 MELK 抑制剂,IC50 值为 0.41 nM。
  • HY-100368A
    MELK-8a hydrochloride Inhibitor 99.23%
    MELK-8a hydrochloride是一种新颖的母体胚胎亮氨酸拉链激酶(MELK)抑制剂,其IC50值为2 nM。
  • HY-15512
    OTSSP167 Inhibitor
    OTSSP167是高活性MELK抑制剂,IC50为0.41 nM,能抑制PSMA1 (proteasome subunit alpha type 1) 和DBNL (drebrin-like) 的磷酸化。