1. NF-κB
  2. NF-κB

NF-κB

NF-κB (Nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. There are five proteins in the mammalian NF-κB family: NF-κB1, NF-κB2, RelA, RelB, c-Rel.

NF-κB 相关产品 (73):

Cat. No. Product Name Effect Purity
  • HY-13453
    BAY 11-7082 Inhibitor 99.64%
    BAY 11-7082 是一种 NF-κB 抑制剂,抑制泛素特异性蛋白酶 (USP)7 和 21,IC50 分别为 0.19 μM 和 0.96 μM。
  • HY-18738
    Pyrrolidinedithiocarbamate ammonium Inhibitor >98.0%
    Pyrrolidinedithiocarbamate ammonium是选择性的NF-kB抑制剂。
  • HY-13982
    JSH-23 Inhibitor 99.10%
    JSH-23 是一种 NF-κB 抑制剂,IC50 值为 7.1 μM。
  • HY-14645
    (-)-DHMEQ Inhibitor 98.05%
    (-)-DHMEQ是DHMEQ的优性异构体,是NF-kB 的抑制剂,能够抑制核里的kB,IC50值是20 ug/mL, 它的活性比(+)-DHMEQ (HY-14645A)强。
  • HY-N0141
    Parthenolide Inhibitor 99.13%
    Parthenolide 是一种 NF-κB 抑制剂,可降低组蛋白脱乙酰酶 1 (HDAC-1) 和 DNA 甲基转移酶 1。
  • HY-P0151
    SN50 Inhibitor
    SN50是可渗透细胞的NF-κB抑制剂。
  • HY-N0622
    Morusin Inhibitor 99.08%
    Morusin是从M. australis分离的去乙烯基化黄酮,具有抗肿瘤,抗氧化,抗菌等各种生物活性。
  • HY-N0170
    Indole-3-carbinol Inhibitor >98.0%
    Indole-3-carbinol 是芳烃受体 (AhR) 的激动剂。
  • HY-13812
    QNZ Inhibitor 99.00%
    QNZ(EVP4593)是6-氨基喹唑啉衍生物,能抑制PMA/PHA诱导的NF-κB活化,IC50为9 nM。
  • HY-10257
    BAY 11-7085 Inhibitor 98.84%
    BAY 11-7085是NF-κB激活和IκBα磷酸化的抑制剂,稳定IκBα的IC50值为10 μM。
  • HY-N0176
    Dihydroartemisinin Inhibitor >99.0%
    Dihydroartemisinin是青蒿素的衍生物,在抗癌方面具有显著功效。
  • HY-N0904
    Ginsenoside C-K Inhibitor 98.06%
    人参皂苷CK(Ginsenoside C-K)是人参皂苷Rb1肠道微生物代谢产物,具有抗增殖和抗炎作用。
  • HY-14655
    Sulfasalazine Inhibitor >98.0%
    Sulfasalazine是治疗类风湿关节炎和溃疡性结肠炎的药物。
  • HY-N2149
    Tomatidine Inhibitor >98.0%
    Tomatidine能够抑制ERK,AKT和核里的NF-κB的磷酸化,有抗炎症的性质。
  • HY-N0191
    Andrographolide Antagonist
    Andrographolide(Andrographis)是一个不可逆的NF-κB通路拮抗剂,能阻止T细胞体外活化,抗病毒,抗炎,抗凋亡,降脂性能。
  • HY-N0197
    Baicalin Inhibitor 98.01%
    Baicalin 是黄芩的重要成分,具有抗氧化、抗肿瘤、抗HIV以及治疗心血管疾病等多重功效。
  • HY-12212
    RTA-408 Inhibitor 98.96%
    RTA-408是转录因子Nrf2活化剂,能抑制免疫转录因子NF-kB。
  • HY-N0039
    Ginsenoside Rb1 Inhibitor 98.10%
    人参皂苷Rb1(Ginsenoside Rb1)是一种天然皂苷,被证实具有抗癌和抗炎症等生物活性。
  • HY-N0045
    Ginsenoside Rg1 Inhibitor >98.0%
    人参皂苷Rg1(Ginsenoside Rg1)是一具有抗炎症和抗癌天然化合物。
  • HY-19387
    Didox Inhibitor 98.72%
    Didox是核糖核苷酸还原酶 (RR) 的强抑制剂, 干扰DNA合成和修复, 通过阻断生产脱氧核糖核苷酸, 具有抗肿瘤作用。