1. Metabolic Enzyme/Protease
  2. DGAT

DGAT

DGAT (acyl-CoA: diacylglycerol acyltransferase) is a transmembrane enzyme that acts in the final and committed step of triacylglycerides (TAGs) synthesis, and it has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT catalyzes the acylation of sn-1,2-diacylglycerol (DAG) at the sn-3 position using an acyl-CoA substrate. DGAT has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT is considered a key enzyme for biotechnological purposes; it might be utilized to increase oil content in oleaginous plant species.

DGAT1 and DGAT2 are two of the enzymes that are responsible for the main part of TAG synthesis in most organisms, and they have been studied in many eukaryotic organisms.

DGAT 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-32219
    T863 Inhibitor 99.08%
    T-863是口服活性的二酰基甘油酰基转移酶1(DGAT1)选择性抑制剂,能结合DGAT1的酰基辅酶A结合位点,抑制三酰甘油在细胞内的合成。
  • HY-16278
    LCQ-908 Inhibitor
    LCQ-908 是新一代的二酰基甘油酰基转移酶1 (DGAT1) 抑制剂,具有抗肥胖,抗糖尿病等功效。
  • HY-10038
    A 922500 Inhibitor 98.50%
    A 922500是一种有效的选择性 DGAT-1 抑制剂,抑制人和小鼠 DGAT-1,IC50 值分别为 9 和22 nM。
  • HY-13009
    PF-04620110 Inhibitor 99.37%
    PF-04620110是口服活性的甘油二酯酰基转移酶-1(DGAT1)抑制剂,IC50为19 nM。
  • HY-N1067
    Xanthohumol Inhibitor 99.68%
    Xanthohumol 是从啤酒花中分离到的黄酮类化合物,是 DGATCOX-1 和 COX-2 的抑制剂,具有抗肿瘤,抗血管生成的作用。
  • HY-15497
    AZD7687 Inhibitor 98.09%
    AZD7687是hDGAT1抑制剂,IC50为80 nM。
  • HY-50670
    DGAT-1 inhibitor 2 Inhibitor
    DGAT-1 inhibitor 2是有效的DGAT-1抑制剂,具有减肥功效。
  • HY-12425
    DGAT1-IN-1 Inhibitor
    DGAT1-IN-1是高效DGAT1抑制剂,IC50值低于10nM(Hep3B细胞过表达DGAT1裂解物测得)。
  • HY-15197
    ABT-046 Inhibitor
    ABT-046是高活性、口服生物相容性的二酰基甘油酰基转移酶1(DGAT-1)抑制剂,IC50为8 nM。