1. Metabolic Enzyme/Protease
  2. Acyltransferase

Acyltransferase

DGAT (acyl-CoA: diacylglycerol acyltransferase) is a transmembrane enzyme that acts in the final and committed step of triacylglycerides (TAGs) synthesis, and it has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT catalyzes the acylation of sn-1,2-diacylglycerol (DAG) at the sn-3 position using an acyl-CoA substrate. DGAT has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT is considered a key enzyme for biotechnological purposes; it might be utilized to increase oil content in oleaginous plant species.

DGAT1 and DGAT2 are two of the enzymes that are responsible for the main part of TAG synthesis in most organisms, and they have been studied in many eukaryotic organisms.

Acyltransferase 相关产品 (21):

Cat. No. Product Name Effect Purity
  • HY-13215
    Avasimibe Inhibitor 99.25%
    Avasimibe是一种可口服的酰基辅酶A: 胆固醇酰基转移酶 (ACAT) 抑制剂,IC50 分别为24 和 9.2 µM。
  • HY-32219
    T863 Inhibitor 99.08%
    T-863是口服活性的二酰基甘油酰基转移酶1(DGAT1)选择性抑制剂,能结合DGAT1的酰基辅酶A结合位点,抑制三酰甘油在细胞内的合成。
  • HY-16278
    LCQ-908 Inhibitor
    LCQ-908 是二酰基甘油酰基转移酶1 (DGAT1) 抑制剂。
  • HY-10038
    A 922500 Inhibitor 98.50%
    A 922500是一种有效,选择性和口服可用的 DGAT-1 抑制剂,抑制小鼠和人DGAT-1的IC50s 分别为 9,22 nM。
  • HY-N1067
    Xanthohumol Inhibitor 99.68%
    Xanthohumol 是从啤酒花中分离到的黄酮类化合物,是 DGATCOX-1 和 COX-2 的抑制剂,具有抗肿瘤,抗血管生成的作用。
  • HY-108339
    PF-06471553 Inhibitor 98.29%
    PF-06471553 是一种有效的,选择性的,可口服的 monoacylglycerol acyltransferase 3 (MGAT3) 抑制剂,IC50 值为 92 nM。
  • HY-112851
    Diacylglycerol acyltransferase inhibitor-1 Inhibitor
    Diacylglycerol acyltransferase inhibitor-1 是一个二酰基甘油酰基转移酶 (DGAT1) 抑制剂。
  • HY-13009
    PF-04620110 Inhibitor 99.37%
    PF-04620110是口服活性的甘油二酯酰基转移酶-1(DGAT1)抑制剂,IC50为19 nM。
  • HY-15497
    AZD7687 Inhibitor 98.09%
    AZD7687是hDGAT1抑制剂,IC50为80 nM。
  • HY-101857
    MGAT2-IN-1 Inhibitor 98.63%
    MGAT2-IN-1 是一种可口服的单酰甘油酰基转移酶 (MGAT2) 抑制剂,对人和小鼠 MGAT2 的 IC50 值分别为 7.8 和 2.4 nM。
  • HY-12425
    DGAT1-IN-1 Inhibitor
    DGAT1-IN-1是高效DGAT1抑制剂,IC50值低于10nM(Hep3B细胞过表达DGAT1裂解物测得)。
  • HY-50670
    DGAT-1 inhibitor 2 Inhibitor
    DGAT-1 inhibitor 2是有效的DGAT-1抑制剂,具有减肥功效。
  • HY-100400A
    K-604 dihydrochloride Inhibitor
    K-604 dihydrochloride 是一种有效的选择性酰基辅酶 A:胆固醇酰基转移酶 1 (ACAT-1) 抑制剂,IC50 为 0.45±0.06 μM。
  • HY-101576
    RP 70676 Inhibitor
    RP 70676 是一种有效的 ACAT 抑制剂,能够抑制对大鼠和兔子中的 ACAT 活性,IC50 值分别为 25 和 44 nM。
  • HY-101627
    YM17E Inhibitor
    YM17E 是一种酰基辅酶a:胆固醇酰基转移酶 (ACAT) 的抑制剂,在兔肝微粒体的体外实验中,IC50 值为 44 nM。
  • HY-15197
    ABT-046 Inhibitor
    ABT-046是高活性、口服生物相容性的二酰基甘油酰基转移酶1(DGAT-1)抑制剂,IC50为8 nM。
  • HY-19183
    E-5324 Inhibitor
    E-5324 是一个强效的酰基辅酶 A:胆固醇酰基转移酶 (ACAT) 抑制剂,其 IC50 值在 44 至 190 nM 之间。
  • HY-16437
    RP-64477 Inhibitor
    RP-64477 是胆固醇酯化酶酰基辅酶 A:胆固醇 O-酰基转移酶 (ACAT) 的有效抑制剂。
  • HY-U00430
    MGAT2-IN-2 Inhibitor
    MGAT2-IN-2 是一种有效的选择性酰基辅酶A:单酰甘油酰基转移酶2 (MGAT2) 抑制剂,IC50 为 3.4 nM。
  • HY-101648
    ACAT-IN-1 cis isomer Inhibitor
    ACAT-IN-1 cis isomer是有效地 ACAT 抑制剂, IC50 值为100 nM。
Isoform Specific Products

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