1. Stem Cell/Wnt
  2. Porcupine

Porcupine

Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.

Porcupine 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-17545
    LGK974 Inhibitor 98.97%
    LGK974是一种有效且特异性的 Porcupine (PORCN) 抑制剂,IC50 为0.1 nM。
  • HY-15659
    Wnt-C59 Inhibitor 99.56%
    Wnt-C59 (C59)是高效可口服的 PORCN 抑制剂,IC50 为 74 pM。
  • HY-100408
    GNF-6231 Inhibitor >98.0%
    GNF-6231是一个强的,有选择性的,能够口服的Porcupine抑制剂能够阻止Wnt信号通路。
  • HY-15825
    IWP L6 Inhibitor >98.0%
    IWP L6是高活性Porcn抑制剂,EC50为0.5 nM。
  • HY-111472
    Porcupine-IN-1 Inhibitor 99.08%
    Porcupine-IN-1是有效的 porcupine 抑制剂,IC50 值为0.5±0.2 nM。
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