1. GPCR/G Protein
  2. Ras


Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras 相关产品 (45):

Cat. No. Product Name Effect Purity
  • HY-U00418
    ARS-1620 Inhibitor 98.02%
    ARS-1620 是一种阻转异构且有选择性的 KRASG12C 抑制剂,具有理想的药代动力学。
  • HY-19706
    ARS-853 Inhibitor 98.39%
    ARS-853是选择性,共价的 KRASG12C 抑制剂,IC50 为2.5 μM。
  • HY-15723A
    NSC 23766 trihydrochloride Inhibitor 99.10%
    NSC 23766 trihydrochloride 是 Rac1 激活的抑制剂。
  • HY-12755
    ML141 Inhibitor 99.21%
    ML141(CID-2950007)是Cdc42高效选择性抑制剂,IC50值为200nM,对其他Rho GTPase家族成员作用力弱。
  • HY-101295
    Pan-RAS-IN-1 Inhibitor >98.0%
  • HY-114277
    AMG-510 Inhibitor
    AMG-510 是一种有效的 KRAS G12C 共价抑制剂。
  • HY-112842
    MBQ-167 Inhibitor 99.26%
    MBQ-167 是 Ras 相关的 C3 型肉毒素底物 (Rac) 和细胞分裂周期蛋白 (Cdc42) 的双抑制剂,其对 Rac 1/2/3 的 IC50 值为 103 nM, 对 Cdc42 的 IC50 值为 78 nM。
  • HY-114436
    MRTX-1257 Inhibitor
    MRTX-1257是不可逆,共价的 KRAS G12C 抑制剂,具有抗癌活性。
  • HY-12646
    Rhosin hydrochloride Inhibitor 99.24%
    Rhosin盐酸盐是Rho特异性抑制剂,结合WT RhoA的Kd值为0.4uM,对Cdc42和Rac1作用无。
  • HY-14754
    Salirasib Inhibitor 98.72%
    Salirasib是一种 Ras 抑制剂,可特异性抑制致癌激活的Ras和生长因子受体介导的Ras激活,从而抑制Ras依赖性肿瘤生长。
  • HY-12874
    CASIN Inhibitor 98.64%
    CASIN是一个选择性的GTPase Cdc42抑制剂,IC50值是2 uM。
  • HY-16659
    EHT 1864 Inhibitor 99.60%
    EHT 1864是Rac1信号转导抑制剂,能调节_gamma_-分泌酶介导的APP。
  • HY-104064
    1A-116 Inhibitor 99.28%
    1A-116 是一种特异性 Rac1 抑制剂。
  • HY-12810
    EHop-016 Inhibitor 99.36%
    EHop-016是Rac GTPase高效选择性抑制剂,在MDA-MB-435细胞中IC50值1.1uM。
  • HY-13991
    CCG-1423 Inhibitor 99.92%
  • HY-13963
    ZCL278 Inhibitor
    ZCL278 是一种选择性的 Cdc42 调节剂,直接结合到 Cdc42,且抑制其功能,Kd 为 11.4 μM。
  • HY-18707
    K-Ras(G12C) inhibitor 12 Inhibitor >98.0%
    K-Ras(G12C) inhibitor 12是K-Ras(G12C)抑制剂, K-Ras(G12C) inhibitor 12作用于H1792细胞, EC50为0.32 μM。
  • HY-12649
    Y16 Inhibitor
    Y16是G蛋白欧联Rho GEFs抑制剂,能协同并增强Rhosin对RhoA的抑制活性。
  • HY-U00417
    ARS-1630 Inhibitor 98.01%
    ARS-1630 是突变型 K-Ras G12C 的新型抑制剂,来自专利 WO 2015054572 A1。
  • HY-12875
    BQU57 Inhibitor >98.0%
    BQU57选择性抑制Ral,选择性比Ras或Rho高, BQU57对H2122 和H358细胞的IC50值分别为 2.0 μM 和1.3 μM。
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