1. GPCR/G Protein
  2. Ras

Ras

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras 相关产品 (28):

Cat. No. Product Name Effect Purity
  • HY-19706
    ARS-853 Inhibitor 98.39%
    ARS-853 是一种选择性的 KRASG12C 抑制剂,IC50 值约为 2.5 μM。
  • HY-15723A
    NSC 23766 trihydrochloride Inhibitor 99.78%
    NSC 23766 trihydrochloride 是特异性的 Rac GTPase 抑制剂,用于癌症研究。
  • HY-16659
    EHT 1864 Inhibitor 99.61%
    EHT 1864是Rac1信号转导抑制剂,能调节_gamma_-分泌酶介导的APP。
  • HY-12755
    ML141 Inhibitor 99.51%
    ML141(CID-2950007)是Cdc42高效选择性抑制剂,IC50值为200nM,对其他Rho GTPase家族成员作用力弱。
  • HY-14754
    Salirasib Inhibitor 98.47%
    Salirasib 是一种有效的,竞争性的 PPMTase 抑制剂,Ki 值为 2.6 μM,同时也抑制 Ras 甲基化。
  • HY-101295
    Pan-RAS-IN-1 Inhibitor >98.0%
    Pan-RAS-IN-1是一种pan-Ras抑制剂,破坏Ras蛋白及其作用子的相互作用。
  • HY-15871
    GGTI298 Trifluoroacetate Inhibitor
    GGTI298 是有效的 GGTase I 抑制剂,能够抑制 geranylgeranylated Rap1A 的过程,对 farnesylated Ha-Ras 的过程也有一定影响,在体内,IC50 值分别为 3 和 > 20 μM。
  • HY-12646
    Rhosin hydrochloride Inhibitor 99.98%
    Rhosin盐酸盐是Rho特异性抑制剂,结合WT RhoA的Kd值为0.4uM,对Cdc42和Rac1作用无。
  • HY-18605
    K-Ras G12C-IN-2 Inhibitor
    K-Ras G12C-IN-2 是一种新型不可逆的 G12C mutant K-Ras 蛋白抑制剂。
  • HY-12649
    Y16 Inhibitor 98.14%
    Y16是G蛋白欧联Rho GEFs抑制剂,能协同并增强Rhosin对RhoA的抑制活性。
  • HY-12874
    CASIN Inhibitor 98.03%
    CASIN是一个选择性的GTPase Cdc42抑制剂,IC50值是2 uM。
  • HY-13963
    ZCL278 Inhibitor
    ZCL278 是一种选择性的 Cdc42 调节剂,直接结合到 Cdc42,且抑制其功能,Kd 为 11.4 μM。
  • HY-18707
    K-Ras(G12C) inhibitor 12 Inhibitor
    K-Ras(G12C) inhibitor 12是K-Ras(G12C)抑制剂, K-Ras(G12C) inhibitor 12作用于H1792细胞, EC50为0.32 μM。
  • HY-12875
    BQU57 Inhibitor 98.33%
    BQU57选择性抑制Ral,选择性比Ras或Rho高, BQU57对H2122 和H358细胞的IC50值分别为 2.0 μM 和1.3 μM。
  • HY-18606
    K-Ras G12C-IN-3 Inhibitor 99.60%
    K-Ras G12C-IN-3是突变型K-Ras G12C不可逆小分子抑制剂。
  • HY-12810
    EHop-016 Inhibitor 98.91%
    EHop-016是Rac GTPase高效选择性抑制剂,在MDA-MB-435细胞中IC50值1.1uM。
  • HY-18604
    K-Ras G12C-IN-1 Inhibitor
    K-Ras G12C-IN-1是突变型K-Ras G12C不可逆小分子抑制剂。
  • HY-13991
    CCG-1423 Inhibitor 99.94%
    CCG-1423是一种新型的RhoA/C介导的基因转录抑制剂,能抑制细胞的转移前列腺癌PC-3细胞侵袭模型。
  • HY-15716
    Kobe0065 Inhibitor 99.26%
    Kobe0065 是一种新颖的,有效的 Ras-Raf 相互作用抑制剂,能够完全抑制 H-Ras·GTP 与 c-Raf-1 RBD 的结合,Ki 值为 46±13 μM。
  • HY-15717
    kobe2602 Inhibitor
    kobe2602是竞争性抑制H-Ras·GTP与c-Raf-1 RBD的结合,Ki为149μM。