2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. 17-Phenyl trinor prostaglandin E2 ethyl amide

17-Phenyl trinor prostaglandin E2 ethyl amide  (Synonyms: 17-Phenyl trinor PGE2 ethyl amide)

目录号: HY-138868
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17-Phenyl trinor prostaglandin E2 ethyl amide (17-Phenyl trinor PGE2 ethyl amide) 是一种 EP1 受体 (EP1 receptor) 激动剂。17-Phenyl trinor prostaglandin E2 ethyl amide 会加重肾功能障碍和肾小球硬化。

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17-Phenyl trinor prostaglandin E2 ethyl amide Chemical Structure

17-Phenyl trinor prostaglandin E2 ethyl amide Chemical Structure

CAS No. : 1219032-20-8

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17-Phenyl trinor prostaglandin E2 ethyl amide 相关抗体

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  • 生物活性

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生物活性

17-Phenyl trinor prostaglandin E2 ethyl amide (17-Phenyl trinor PGE2 ethyl amide) is a EP1 receptor agonist. 17-Phenyl trinor prostaglandin E2 ethyl amide aggravates renal dysfunction and glomerulosclerosis[1].

体内研究
(In Vivo)

17-Phenyl trinor prostaglandin E2 ethyl amide (0.3 µg/g; i.p.; three times a week for 12 weeks) 会加重六分之五肾切除肾纤维化模型小鼠的肾功能障碍和肾小球硬化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-12 weeks, 15-20 g, C57/BL6 male mice (five‑sixths nephrectomy renal fibrosis model)[1]
Dosage: 0.3 µg/g
Administration: I.p.; three times a week for 12 weeks
Result: Increased the plasma blood urea nitrogen (BUN) levels and plasma creatinine (Cr) concentration, increased the extracellular matrix and the area of collagen deposition, upregulated the protein of expression of Col1, GRP78, TRPC1 and PERK in 5/6 Nx mice.
分子量

413.55

Formula

C25H35NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

17-Phenyl trinor prostaglandin E2 ethyl amide 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

17-Phenyl trinor prostaglandin E2 ethyl amide1219032-20-817-Phenyl trinor PGE2 ethyl amideProstaglandin ReceptorCol1GRP78TRPC1PERKglomerulosclerosisInhibitorinhibitorinhibit

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