2. GPCR/G Protein PI3K/Akt/mTOR
  3. Adhesion G Protein-coupled Receptors (AGPCRs) PI3K
  4. (3aS,4R,9bR)-G-1

(3aS,4R,9bR)-G-1 是一种高选择性 G 蛋白偶联受体 GPR30 (GPER) 激动剂， Ki 值约为 7 nM。(3aS,4R,9bR)-G-1 通过 GPR30 激活细胞内钙动员、PI3K 信号等快速信号通路，促进子宫上皮细胞增殖，发挥抗抑郁作用。(3aS,4R,9bR)-G-1 有望用于乳腺癌和抑郁症的研究。

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(3aS,4R,9bR)-G-1 Chemical Structure

(3aS,4R,9bR)-G-1 Chemical Structure

CAS No. : 925419-53-0

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规格 是否有货
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Other Forms of (3aS,4R,9bR)-G-1:

(3aS,4R,9bR)-G-1 相关抗体

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(3aS,4R,9bR)-G-1 is a highly selective G protein-coupled receptor GPR30 (GPER) agonist with a Ki value of approximately 7 nM. (3aS,4R,9bR)-G-1 activates rapid signaling pathways such as intracellular calcium mobilization and PI3K signaling through GPR30, promoting uterine epithelial cell proliferation and exerting antidepressant effects. (3aS,4R,9bR)-G-1 is promising for research of breast cancer and depression[1].

分子量

412.28

Formula

C21H18BrNO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(3aS,4R,9bR)-G-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(3aS,4R,9bR)-G-1925419-53-0Adhesion G Protein-coupled Receptors (AGPCRs)PI3KPhosphoinositide 3-kinaseGPERintracellular calcium mobilizationbreast cancerdepressionInhibitorinhibitorinhibit

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