2. MAPK/ERK Pathway Stem Cell/Wnt JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. JNK ERK p38 MAPK EGFR TNF Receptor
  4. (3S)-Tanzisertib hydrochloride

(3S)-Tanzisertib hydrochloride  (Synonyms: (3S)-CC-930 hydrochloride)

目录号: HY-15495B
产品使用指南 技术支持

(3S)-Tanzisertib (hydrochloride) ((3S)-CC-930 (hydrochloride)) 是一种具有口服活性的 JNK 抑制剂 (JNK1、JNK2 和 JNK3 的 IC50 分别为 61、7 和 6 nM)。(3S)-Tanzisertib (hydrochloride) 可选择性抑制 ERK1、p38α 和 EGFR (IC50 分别为 0.48、3.4 和 0.38 μM)。(3S)-Tanzisertib (hydrochloride) 在急性大鼠 PK-PD 模型中可抑制 LPS 诱导的 TNFα 生成。(3S)-Tanzisertib (hydrochloride) 可用于特发性肺纤维化 (IPF) 的研究。

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(3S)-Tanzisertib hydrochloride Chemical Structure

(3S)-Tanzisertib hydrochloride Chemical Structure

CAS No. : 2517855-91-1

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Other Forms of (3S)-Tanzisertib hydrochloride:

(3S)-Tanzisertib hydrochloride 相关抗体

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查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

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ERK ERK1 ERK2 ERK5 ERK8

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(3S)-Tanzisertib (hydrochloride) ((3S)-CC-930 (hydrochloride)) is an orally active JNK inhibitor (IC50 values for JNK1, JNK2, and JNK3 are 61, 7, and 6 nM, respectively). (3S)-Tanzisertib (hydrochloride) selectively inhibits ERK1, p38α, and EGFR (IC50 = 0.48, 3.4, and 0.38 μM, respectively). (3S)-Tanzisertib (hydrochloride) inhibits LPS-induced TNFα production in an acute rat PK-PD model. (3S)-Tanzisertib (hydrochloride) can be used in idiopathic pulmonary fibrosis (IPF) research[1].

IC50 & Target[1]

JNK1

61 nM (IC50)

JNK2

7 nM (IC50)

JNK3

6 nM (IC50)

ERK1

0.48 μM (IC50)

p38α

3.4 μM (IC50)

药代动力学
(Parmacokinetics)
Species Dose Route Indicator value
Rat 2 mg/kg i.v. CL 39 mL/min/kg
Rat 2 mg/kg i.v. AUC 1.9
Rat 2 mg/kg i.v. MRT 0.7 hr
分子量

484.90

同用名

(3S)-CC-930 hydrochloride

Formula

C21H24ClF3N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(3S)-Tanzisertib hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(3S)-Tanzisertib2517855-91-1(3S)-CC-930JNKERKp38 MAPKEGFRTNF Receptorc-Jun N-terminal kinaseExtracellular signal regulated kinasesEpidermal growth factor receptorErbB-1HER1Tumor Necrosis Factor ReceptorTNFRidiopathic pulmonary fibrosis (IPF)anti-inflammatoryJNK cellLPS-induced TNFα production PK-PD modelInhibitorinhibitorinhibit

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