2. Membrane Transporter/Ion Channel Anti-infection Apoptosis
  3. Sodium Channel HIV Apoptosis
  4. 5-(N,N-Hexamethylene)-amiloride (Standard)

5-(N,N-Hexamethylene)-amiloride (Standard) 

目录号: HY-128067R 纯度: ≥98%
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5-(N,N-Hexamethylene)-amiloride (Standard） 是 5-(N,N-Hexamethylene)-amiloride 的分析标准品。本产品用于研究及分析应用。5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride)，是 amiloride 的衍生物，也是一种有效的 Na+/H+ 交换抑制剂，降低白血病细胞的细胞内 pH (pHi) 并诱导其凋亡。5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) 也是一种 HIV-1 Vpu 病毒离子通道抑制剂，抑制培养在 L929 细胞中的小鼠肝炎病毒 (MHV) 复制和 HCoV229E 复制，EC50 值分别为 3.91 μM 和 1.34 μM。

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5-(N,N-Hexamethylene)-amiloride (Standard) Chemical Structure

5-(N,N-Hexamethylene)-amiloride (Standard) Chemical Structure

CAS No. : 1428-95-1

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生物活性

5-(N,N-Hexamethylene)-amiloride (Standard) is the analytical standard of 5-(N,N-Hexamethylene)-amiloride. This product is intended for research and analytical applications. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively.

分子量

311.77

Formula

C12H18ClN7O
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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Keywords:

5-(N,N-Hexamethylene)-amiloride (Standard)1428-95-1Sodium ChannelHIVApoptosisNa channelsNa+ channelsHuman immunodeficiency virusleukemic cellsHCoV229EMHVmouse hepatitis virusVpu virus ion channelInhibitorinhibitorinhibit

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