2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. 8(9)-EET

（±）8（9）-EET 是肾皮质中的一种主要的细胞色素 P450（CYP450）代谢产物[1][2]。当其浓度为 1 微摩尔时，它能在 HEK293 细胞中激活 PPARα，但以 PPARα依赖性和非依赖性的方式抑制由 IL-1β 诱导的 NF-κB 活性。 通过氧消耗和产物生成测定法，当其浓度为 50 微摩尔时，它也是 COX-1 和 COX-2 的底物。

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8(9)-EET Chemical Structure

8(9)-EET Chemical Structure

CAS No. : 82864-43-5

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Other Forms of 8(9)-EET:

8(9)-EET 相关抗体

Top Publications Citing Use of Products

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex[1][2]. It activates PPARα in HEK293 cells when used at a concentration of 1 μM but inhibits NF-κB activity induced by IL-1β in a PPARα-dependent and -independent fashion[3]. It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM [4].

分子量

320.47

Formula

C20H32O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

8(9)-EET 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8(9)-EET82864-43-5PPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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目录号：
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