1. Immunology/Inflammation
  2. CD73
  3. AB-680

AB-680 

目录号: HY-125286
产品使用指南

AB-680 是一种有效、可逆、选择性的 CD73 (胞外核苷酸酶) 抑制剂,对 hCD73 的 Ki 值为 4.9 pM,对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。具有抗肿瘤活性。

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AB-680 Chemical Structure

AB-680 Chemical Structure

CAS No. : 2105904-82-1

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Description

AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

IC50 & Target

Ki: 4.9 pM (hCD73)[1]
IC50: 43 pM (Soluble hCD73)[1]

In Vitro

AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

580.82

Formula

C₂₀H₂₄ClFN₄O₉P₂

CAS No.

2105904-82-1

SMILES

O=P(CP(O)(O)=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(Cl)C=C3N[C@H](C4=CC=CC=C4F)C)=C3C=N2)O1

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
AB-680
目录号:
HY-125286
需求量:

AB-680

Cat. No.: HY-125286