1. Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
  2. IRAK
  3. AZ1495

AZ1495 

目录号: HY-111101 纯度: 99.83%
产品使用指南

AZ1495 (compound 28) 是具有口服活性的,白介素-1受体相关激酶 4 (IRAK4) 的抑制剂,其对 IRAK4 和 IRAK1 的 IC50 值分别为 5 nM 和 23 nM。具有治疗突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 的活性。

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AZ1495 Chemical Structure

AZ1495 Chemical Structure

CAS No. : 2196204-23-4

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥605 In-stock
5 mg ¥5500 In-stock
10 mg ¥8500 In-stock
25 mg ¥17500 In-stock
50 mg ¥27500 In-stock
100 mg ¥39500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL)[1].

IC50 & Target[1]

IRAK4

5 nM (IC50)

IRAK1

23 nM (IC50)

CLK1

50 nM (IC50)

CLK2

5 nM (IC50)

CLK4

8 nM (IC50)

haspin

4 nM (IC50)

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (25.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5940 mL 12.9702 mL 25.9403 mL
5 mM 0.5188 mL 2.5940 mL 5.1881 mL
10 mM 0.2594 mL 1.2970 mL 2.5940 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.59 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.59 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.59 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

385.50

Formula

C₂₁H₃₁N₅O₂

CAS No.

2196204-23-4

SMILES

C1(C(C2CCOCC2)=CN3)=C3N=CN=C1N[C@@H]4CC[C@@H](N5CCOCC5)CC4

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.83%

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
AZ1495
目录号:
HY-111101
需求量:

AZ1495

Cat. No.: HY-111101