1. Epigenetics
  2. Histone Demethylase
  3. CBB1007 hydrochloride

CBB1007 hydrochloride 

目录号: HY-15313B 纯度: ≥98.0%
COA 产品使用指南

CBB1007 hydrochloride 是组蛋白去甲基化酶 LSD1 高效底物竞争性,可逆的,选择性的 抑制剂,对 hLSD1 的 IC50 值为 5.27 uM。

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CBB1007 hydrochloride Chemical Structure

CBB1007 hydrochloride Chemical Structure

CAS No. : 2070014-96-7

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2 mg ¥1550
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5 mg ¥2325
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10 mg ¥3534
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50 mg ¥8370
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CBB1007 hydrochloride 的其他形式现货产品:

Other Forms of CBB1007 hydrochloride:

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MCE 顾客使用本产品发表的 1 篇科研文献

WB

    CBB1007 hydrochloride purchased from MCE. Usage Cited in: BMC Neurosci. 2022 Nov 10;23(1):63.  [Abstract]

    CBB1007 (CBB) elevates H3K4me2 expression in RGC-5 cells, after which miR-21-5p expression levels are increased .

    查看 Histone Demethylase 亚型特异性产品:

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    CBB1007 Hcl is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1). IC50 Value: 5.27 uM Target: hLSD1 CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 ≤ 5 μM), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM). CBB1007 was Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50 ≥ 100 μM).

    IC50 & Target

    KDM1/LSD1

     

    分子量

    716.91

    Formula

    C27H39Cl5N8O4

    CAS 号
    性状

    固体

    颜色

    White to off-white

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    纯度 & 产品资料
    参考文献

    CBB1007 hydrochloride 相关分类

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    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    CBB1007 hydrochloride
    目录号:
    HY-15313B
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